Monitoring fertility (semen analysis) by cancer survivors who banked sperm prior to cancer treatment
Authors: Pacey, A.A., Merrick, H., Arden-Close, E., Morris, K., Barton, L.C., Crook, A.J., Tomlinson, M.J., Wright, E., Rowe, R. and Eiser, C.
Journal: Human Reproduction
Volume: 27
Issue: 11
Pages: 3132-3139
eISSN: 1460-2350
ISSN: 0268-1161
DOI: 10.1093/humrep/des300
Abstract:Study Question What medical and psychological variables predict why men with banked sperm do not return for semen analysis after their cancer treatment has ended? Summary Answer Men who decline the offer of semen analysis are less likely to have reported adverse side effects during cancer treatment, and have a more negative experience of banking sperm and a more negative attitude towards disposal of their stored semen than those who attend. What is Known Already Previous authors have noted that male cancer survivors seem reluctant to have their fertility tested after their treatment has ended. Moreover, the utilization rates of banked sperm are very low (<10) and the majority of samples are kept for many years without being used. Study Design, Size and Durationa cross-sectional study of 499 cancer survivors who were sent a questionnaire about their views on sperm banking, fertility and post-treatment semen analysis between April 2008 and December 2010. Participants and Setting Men (aged 18-55 years) who had banked sperm in Sheffield and Nottingham (UK) prior to gonadotoxic treatment for cancer more than 5 years previously. Main Results and The Role of ChanceCompleted questionnaires were received from 193 men (38.7 response rate) whose samples had been banked for 9.18 ± 3.70 years (range 4.94-26.21) and whose current age was 35.08 ± 7.08 years (range 21.58-54.34; mean ± SD). One-third (35.8) had never attended for semen analysis. In multivariate analysis, the odds of not attending for semen analysis were significantly greater among men who did not experience adverse treatment side effects [odds ratio (OR) 5.72, 95 confidence interval (CI) 2.10-15.56], who reported a more negative experience of banking sperm (OR 1.82, 95 CI 1.17-2.82) and a more negative attitude to disposal of their stored semen (OR 1.56, 95 CI 1.01-2.42).LIMITATIONS AND REASONS FOR CAUTIONOnly 38.7 of those eligible agreed to take part. We do not know the characteristics of men who declined to take part, if they agreed to attend semen analysis without completing the questionnaire or whether they had chosen to have semen analysis performed elsewhere (e.g. private sector). Some of the measures used (e.g. experience of banking sperm) relied on men's recall of events many years previously. Wider Implications of The Findings New strategies are required to encourage these men to engage with fertility monitoring programmes if sperm banks are to be used cost-effectively and men are to be given appropriate fertility advice. Study Funding and Competing Interests This paper was supported by funding from Cancer Research-UK to C.E., A.A.P. and R.R. (C481/A8141). The views expressed are those of the authors. No competing interests declared. © 2012 The Author.
https://eprints.bournemouth.ac.uk/21466/
Source: Scopus
Monitoring fertility (semen analysis) by cancer survivors who banked sperm prior to cancer treatment.
Authors: Pacey, A.A., Merrick, H., Arden-Close, E., Morris, K., Barton, L.C., Crook, A.J., Tomlinson, M.J., Wright, E., Rowe, R. and Eiser, C.
Journal: Hum Reprod
Volume: 27
Issue: 11
Pages: 3132-3139
eISSN: 1460-2350
DOI: 10.1093/humrep/des300
Abstract:STUDY QUESTION: What medical and psychological variables predict why men with banked sperm do not return for semen analysis after their cancer treatment has ended? SUMMARY ANSWER: Men who decline the offer of semen analysis are less likely to have reported adverse side effects during cancer treatment, and have a more negative experience of banking sperm and a more negative attitude towards disposal of their stored semen than those who attend. WHAT IS KNOWN ALREADY: Previous authors have noted that male cancer survivors seem reluctant to have their fertility tested after their treatment has ended. Moreover, the utilization rates of banked sperm are very low (<10%) and the majority of samples are kept for many years without being used. STUDY DESIGN, SIZE AND DURATION: A cross-sectional study of 499 cancer survivors who were sent a questionnaire about their views on sperm banking, fertility and post-treatment semen analysis between April 2008 and December 2010. PARTICIPANTS AND SETTING: Men (aged 18-55 years) who had banked sperm in Sheffield and Nottingham (UK) prior to gonadotoxic treatment for cancer more than 5 years previously. MAIN RESULTS AND THE ROLE OF CHANCE: Completed questionnaires were received from 193 men (38.7% response rate) whose samples had been banked for 9.18 ± 3.70 years (range = 4.94-26.21) and whose current age was 35.08 ± 7.08 years (range = 21.58-54.34; mean ± SD). One-third (35.8%) had never attended for semen analysis. In multivariate analysis, the odds of not attending for semen analysis were significantly greater among men who did not experience adverse treatment side effects [odds ratio (OR) = 5.72, 95% confidence interval (CI) = 2.10-15.56], who reported a more negative experience of banking sperm (OR = 1.82, 95% CI = 1.17-2.82) and a more negative attitude to disposal of their stored semen (OR = 1.56, 95% CI = 1.01-2.42). LIMITATIONS AND REASONS FOR CAUTION: Only 38.7% of those eligible agreed to take part. We do not know the characteristics of men who declined to take part, if they agreed to attend semen analysis without completing the questionnaire or whether they had chosen to have semen analysis performed elsewhere (e.g. private sector). Some of the measures used (e.g. experience of banking sperm) relied on men's recall of events many years previously. WIDER IMPLICATIONS OF THE FINDINGS: New strategies are required to encourage these men to engage with fertility monitoring programmes if sperm banks are to be used cost-effectively and men are to be given appropriate fertility advice. STUDY FUNDING AND COMPETING INTERESTS: This paper was supported by funding from Cancer Research-UK to C.E., A.A.P. and R.R. (C481/A8141). The views expressed are those of the authors. No competing interests declared.
https://eprints.bournemouth.ac.uk/21466/
Source: PubMed
Preferred by: Emily Arden-Close
Monitoring fertility (semen analysis) by cancer survivors who banked sperm prior to cancer treatment
Authors: Pacey, A.A., Merrick, H., Arden-Close, E., Morris, K., Barton, L.C., Crook, A.J., Tomlinson, M.J., Wright, E., Rowe, R. and Eiser, C.
Journal: HUMAN REPRODUCTION
Volume: 27
Issue: 11
Pages: 3132-3139
eISSN: 1460-2350
ISSN: 0268-1161
DOI: 10.1093/humrep/des300
https://eprints.bournemouth.ac.uk/21466/
Source: Web of Science (Lite)
Monitoring fertility (semen analysis) by cancer survivors who banked sperm prior to cancer treatment.
Authors: Pacey, A.A., Merrick, H., Arden-Close, E., Morris, K., Barton, L.C., Crook, A.J., Tomlinson, M.J., Wright, E., Rowe, R. and Eiser, C.
Journal: Human reproduction (Oxford, England)
Volume: 27
Issue: 11
Pages: 3132-3139
eISSN: 1460-2350
ISSN: 0268-1161
DOI: 10.1093/humrep/des300
Abstract:Study question
What medical and psychological variables predict why men with banked sperm do not return for semen analysis after their cancer treatment has ended?Summary answer
Men who decline the offer of semen analysis are less likely to have reported adverse side effects during cancer treatment, and have a more negative experience of banking sperm and a more negative attitude towards disposal of their stored semen than those who attend.What is known already
Previous authors have noted that male cancer survivors seem reluctant to have their fertility tested after their treatment has ended. Moreover, the utilization rates of banked sperm are very low (<10%) and the majority of samples are kept for many years without being used.Study design, size and duration
A cross-sectional study of 499 cancer survivors who were sent a questionnaire about their views on sperm banking, fertility and post-treatment semen analysis between April 2008 and December 2010.Participants and setting
Men (aged 18-55 years) who had banked sperm in Sheffield and Nottingham (UK) prior to gonadotoxic treatment for cancer more than 5 years previously.Main results and the role of chance
Completed questionnaires were received from 193 men (38.7% response rate) whose samples had been banked for 9.18 ± 3.70 years (range = 4.94-26.21) and whose current age was 35.08 ± 7.08 years (range = 21.58-54.34; mean ± SD). One-third (35.8%) had never attended for semen analysis. In multivariate analysis, the odds of not attending for semen analysis were significantly greater among men who did not experience adverse treatment side effects [odds ratio (OR) = 5.72, 95% confidence interval (CI) = 2.10-15.56], who reported a more negative experience of banking sperm (OR = 1.82, 95% CI = 1.17-2.82) and a more negative attitude to disposal of their stored semen (OR = 1.56, 95% CI = 1.01-2.42).Limitations and reasons for caution
Only 38.7% of those eligible agreed to take part. We do not know the characteristics of men who declined to take part, if they agreed to attend semen analysis without completing the questionnaire or whether they had chosen to have semen analysis performed elsewhere (e.g. private sector). Some of the measures used (e.g. experience of banking sperm) relied on men's recall of events many years previously.Wider implications of the findings
New strategies are required to encourage these men to engage with fertility monitoring programmes if sperm banks are to be used cost-effectively and men are to be given appropriate fertility advice.Study funding and competing interests
This paper was supported by funding from Cancer Research-UK to C.E., A.A.P. and R.R. (C481/A8141). The views expressed are those of the authors. No competing interests declared.https://eprints.bournemouth.ac.uk/21466/
Source: Europe PubMed Central
Monitoring fertility (semen analysis) by cancer survivors who banked sperm prior to cancer treatment.
Authors: Pacey, A.A., Merrick, H., Arden-Close, E., Morris, K., Barton, L.C., Crook, A.J., Tomlinson, M.J., Wright, E., Rowe, R. and Eiser, C.
Journal: Human Reproduction
Volume: 27
Issue: 11
Pages: 3132-3139
ISSN: 0268-1161
Abstract:What medical and psychological variables predict why men with banked sperm do not return for semen analysis after their cancer treatment has ended?
https://eprints.bournemouth.ac.uk/21466/
Source: BURO EPrints