Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats
Authors: Appleton, K.M., Grippo, A.J., Beltz, T.G. and Johnson, A.K.
Journal: Prostaglandins Leukotrienes and Essential Fatty Acids
Volume: 95
Pages: 11-18
eISSN: 1532-2823
ISSN: 0952-3278
DOI: 10.1016/j.plefa.2014.11.010
Abstract:n-3 Polyunsaturated fatty acids (n-3PUFAs) may be beneficial for anxiety and depression under stressful conditions. Studies however, typically utilise physical or sudden physiological stress, while gradual physiological stress is also relevant to human conditions. Using deoxycorticosterone acetate (DOCA) administration to induce gradual physiological stress, this study investigated the impact of n-3PUFAs under gradual physiological stress in rats. Animals (aged 2 months) (N=8-12/group) received daily injections of DOCA or vehicle and were concurrently fed a high n-3PUFA or control diet for eight weeks. Behavioural measures were taken throughout. Behavioural tests and physiological measures were conducted after six and eight weeks respectively. DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. These findings demonstrate disruptions to the renin-angiotensin-aldosterone system, a result of mild physiological stress, that also impact on anxiety behaviours. No effects of n-3PUFAs were found.
https://eprints.bournemouth.ac.uk/21648/
Source: Scopus
Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats.
Authors: Appleton, K.M., Grippo, A.J., Beltz, T.G. and Johnson, A.K.
Journal: Prostaglandins Leukot Essent Fatty Acids
Volume: 95
Pages: 11-18
eISSN: 1532-2823
DOI: 10.1016/j.plefa.2014.11.010
Abstract:n-3 Polyunsaturated fatty acids (n-3PUFAs) may be beneficial for anxiety and depression under stressful conditions. Studies however, typically utilise physical or sudden physiological stress, while gradual physiological stress is also relevant to human conditions. Using deoxycorticosterone acetate (DOCA) administration to induce gradual physiological stress, this study investigated the impact of n-3PUFAs under gradual physiological stress in rats. Animals (aged 2 months) (N=8-12/group) received daily injections of DOCA or vehicle and were concurrently fed a high n-3PUFA or control diet for eight weeks. Behavioural measures were taken throughout. Behavioural tests and physiological measures were conducted after six and eight weeks respectively. DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. These findings demonstrate disruptions to the renin-angiotensin-aldosterone system, a result of mild physiological stress, that also impact on anxiety behaviours. No effects of n-3PUFAs were found.
https://eprints.bournemouth.ac.uk/21648/
Source: PubMed
Preferred by: Katherine Appleton
Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats
Authors: Appleton, K.M., Grippo, A.J., Beltz, T.G. and Johnson, A.K.
Journal: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume: 95
Pages: 11-18
eISSN: 1532-2823
ISSN: 0952-3278
DOI: 10.1016/j.plefa.2014.11.010
https://eprints.bournemouth.ac.uk/21648/
Source: Web of Science (Lite)
Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats.
Authors: Appleton, K.M., Grippo, A.J., Beltz, T.G. and Johnson, A.K.
Journal: Prostaglandins, leukotrienes, and essential fatty acids
Volume: 95
Pages: 11-18
eISSN: 1532-2823
ISSN: 0952-3278
DOI: 10.1016/j.plefa.2014.11.010
Abstract:n-3 Polyunsaturated fatty acids (n-3PUFAs) may be beneficial for anxiety and depression under stressful conditions. Studies however, typically utilise physical or sudden physiological stress, while gradual physiological stress is also relevant to human conditions. Using deoxycorticosterone acetate (DOCA) administration to induce gradual physiological stress, this study investigated the impact of n-3PUFAs under gradual physiological stress in rats. Animals (aged 2 months) (N=8-12/group) received daily injections of DOCA or vehicle and were concurrently fed a high n-3PUFA or control diet for eight weeks. Behavioural measures were taken throughout. Behavioural tests and physiological measures were conducted after six and eight weeks respectively. DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. These findings demonstrate disruptions to the renin-angiotensin-aldosterone system, a result of mild physiological stress, that also impact on anxiety behaviours. No effects of n-3PUFAs were found.
https://eprints.bournemouth.ac.uk/21648/
Source: Europe PubMed Central
Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats.
Authors: Appleton, K., Grippo, A.J., Beltz, T.G. and Johnson, A.K.
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Volume: 95
Pages: 11-18
ISSN: 0952-3278
Abstract:n-3 Polyunsaturated fatty acids (n-3PUFAs) may be beneficial for anxiety and depression under stressful conditions. Studies however, typically utilise physical or sudden physiological stress, while gradual physiological stress is also relevant to human conditions. Using deoxycorticosterone acetate (DOCA) administration to induce gradual physiological stress, this study investigated the impact of n-3PUFAs under gradual physiological stress in rats. Animals (aged 2 months) (N=8-12/group) received daily injections of DOCA or vehicle and were concurrently fed a high n-3PUFA or control diet for eight weeks. Behavioural measures were taken throughout. Behavioural tests and physiological measures were conducted after six and eight weeks respectively. DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. These findings demonstrate disruptions to the renin-angiotensin-aldosterone system, a result of mild physiological stress, that also impact on anxiety behaviours. No effects of n-3PUFAs were found.
https://eprints.bournemouth.ac.uk/21648/
Source: BURO EPrints