Interaction Between Methadone and Ether Peroxides to Produce 1, 5-dimethyl-3, 3-diphenyl-2-ethylidene-pyrrolidine the Major Cyclic Metabolite of Methadone
Authors: Osselton, M.D.
Journal: Journal of the Forensic Science Society
Volume: 16
Issue: 4
Pages: 299-303
ISSN: 0015-7368
DOI: 10.1016/S0015-7368(76)71076-4
Abstract:The compound 1,5-dimethyl-3,3-diphenyl-2-ethylidene-pyrrolidine, known as a urinary metabolite of methadone, is formed during the extraction of methadone from human urine when impure diethyl ether is used as the extracting solvent. Reaction between methadone and diethyl ether enriched with peroxides provides a simple and rapid method for the preparation of 1,5-dimethyl,-3,3-diphenyl-2-ethylidene-pyrrolidine. © 1976, Forensic Science Society. All rights reserved.
Source: Scopus
Interaction between methadone and ether peroxides to produce 1,5-dimethyl-3, 3-diphenyl-2-ethylidene-pyrrolidine the major cyclic metabolite of methadone.
Authors: Osselton, M.D.
Journal: J Forensic Sci Soc
Volume: 16
Issue: 4
Pages: 299-303
ISSN: 0015-7368
DOI: 10.1016/s0015-7368(76)71076-4
Source: PubMed
Preferred by: David Osselton
Interaction between methadone and ether peroxides to produce 1,5-dimethyl-3, 3-diphenyl-2-ethylidene-pyrrolidine the major cyclic metabolite of methadone.
Authors: Osselton, M.D.
Journal: Journal - Forensic Science Society
Volume: 16
Issue: 4
Pages: 299-303
eISSN: 1876-4282
ISSN: 0015-7368
DOI: 10.1016/s0015-7368(76)71076-4
Source: Europe PubMed Central