Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat

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Authors: King, V.R., Huang, W.L., Dyall, S., Curran, O.E., Priestley, J.V. and Michael-Titus, A.T.

http://eprints.bournemouth.ac.uk/21698/

Journal: The Journal of Neuroscience

Volume: 26

Issue: 17

Pages: 4672-4680

This data was imported from PubMed:

Authors: King, V.R., Huang, W.L., Dyall, S.C., Curran, O.E., Priestley, J.V. and Michael-Titus, A.T.

http://eprints.bournemouth.ac.uk/21698/

Journal: J Neurosci

Volume: 26

Issue: 17

Pages: 4672-4680

eISSN: 1529-2401

DOI: 10.1523/JNEUROSCI.5539-05.2006

Spinal cord injury (SCI) is a cause of major neurological disability, and no satisfactory treatment is currently available. Evidence suggests that polyunsaturated fatty acids (PUFAs) could target some of the pathological mechanisms that underlie damage after SCI. We examined the effects of treatment with PUFAs after lateral spinal cord hemisection in the rat. The omega-3 PUFAs alpha-linolenic acid and docosahexaenoic acid (DHA) injected 30 min after injury induced significantly improved locomotor performance and neuroprotection, including decreased lesion size and apoptosis and increased neuronal and oligodendrocyte survival. Evidence showing a decrease in RNA/DNA oxidation suggests that the neuroprotective effect of omega-3 PUFAs involved a significant antioxidant function. In contrast, animals treated with arachidonic acid, an omega-6 PUFA, had a significantly worse outcome than controls. We confirmed the neuroprotective effect of omega-3 PUFAs by examining the effects of DHA treatment after spinal cord compression injury. Results indicated that DHA administered 30 min after spinal cord compression not only greatly increased survival of neurons but also resulted in significantly better locomotor performance for up to 6 weeks after injury. This report shows a striking difference in efficacy between the effects of treatment with omega-3 and omega-6 PUFAs on the outcome of SCI, with omega-3 PUFAs being neuroprotective and omega-6 PUFAs having a damaging effect. Given the proven clinical safety of omega-3 PUFAs, our observations show that these PUFAs have significant therapeutic potential in SCI. In contrast, the use of preparations enriched in omega-6 PUFAs after injury could worsen outcome after SCI.

This data was imported from Scopus:

Authors: King, V.R., Huang, W.L., Dyall, S.C., Curran, O.E., Priestley, J.V. and Michael-Titus, A.T.

http://eprints.bournemouth.ac.uk/21698/

Journal: Journal of Neuroscience

Volume: 26

Issue: 17

Pages: 4672-4680

eISSN: 0270-6474

ISSN: 0270-6474

DOI: 10.1523/JNEUROSCI.5539-05.2006

Spinal cord injury (SCI) is a cause of major neurological disability, and no satisfactory treatment is currently available. Evidence suggests that polyunsaturated fatty acids (PUFAs) could target some of the pathological mechanisms that underlie damage after SCI. We examined the effects of treatment with PUFAs after lateral spinal cord hemisection in the rat. The ω-3 PUFAs α-linolenic acid and docosahexaenoic acid (DHA) injected 30 min after injury induced significantly improved locomotor performance and neuroprotection, including decreased lesion size and apoptosis and increased neuronal and oligodendrocyte survival. Evidence showing a decrease in RNA/DNA oxidation suggests that the neuroprotective effect of ω-3 PUFAs involved a significant antioxidant function. In contrast, animals treated with arachidonic acid, an ω-6 PUFA, had a significantly worse outcome than controls. We confirmed the neuroprotective effect of ω-3 PUFAs by examining the effects of DHA treatment after spinal cord compression injury. Results indicated that DHA administered 30 min after spinal cord compression not only greatly increased survival of neurons but also resulted in significantly better locomotor performance for up to 6 weeks after injury. This report shows a striking difference in efficacy between the effects of treatment with ω-3 and ω-6 PUFAs on the outcome of SCI, with ω-3 PUFAs being neuroprotective and ω-6 PUFAs having a damaging effect. Given the proven clinical safety of ω-3 PUFAs, our observations show that these PUFAs have significant therapeutic potential in SCI. In contrast, the use of preparations enriched in ω-6 PUFAs after injury could worsen outcome after SCI. Copyright © 2006 Society for Neuroscience.

This data was imported from Web of Science (Lite):

Authors: King, V.R., Huang, W.L., Dyall, S.C., Curran, O.E., Priestley, J.V. and Michael-Titus, A.T.

http://eprints.bournemouth.ac.uk/21698/

Journal: JOURNAL OF NEUROSCIENCE

Volume: 26

Issue: 17

Pages: 4672-4680

ISSN: 0270-6474

DOI: 10.1523/JNEUROSCI.5539-05.2006

This data was imported from Europe PubMed Central:

Authors: King, V.R., Huang, W.L., Dyall, S.C., Curran, O.E., Priestley, J.V. and Michael-Titus, A.T.

http://eprints.bournemouth.ac.uk/21698/

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Volume: 26

Issue: 17

Pages: 4672-4680

eISSN: 1529-2401

ISSN: 0270-6474

Spinal cord injury (SCI) is a cause of major neurological disability, and no satisfactory treatment is currently available. Evidence suggests that polyunsaturated fatty acids (PUFAs) could target some of the pathological mechanisms that underlie damage after SCI. We examined the effects of treatment with PUFAs after lateral spinal cord hemisection in the rat. The omega-3 PUFAs alpha-linolenic acid and docosahexaenoic acid (DHA) injected 30 min after injury induced significantly improved locomotor performance and neuroprotection, including decreased lesion size and apoptosis and increased neuronal and oligodendrocyte survival. Evidence showing a decrease in RNA/DNA oxidation suggests that the neuroprotective effect of omega-3 PUFAs involved a significant antioxidant function. In contrast, animals treated with arachidonic acid, an omega-6 PUFA, had a significantly worse outcome than controls. We confirmed the neuroprotective effect of omega-3 PUFAs by examining the effects of DHA treatment after spinal cord compression injury. Results indicated that DHA administered 30 min after spinal cord compression not only greatly increased survival of neurons but also resulted in significantly better locomotor performance for up to 6 weeks after injury. This report shows a striking difference in efficacy between the effects of treatment with omega-3 and omega-6 PUFAs on the outcome of SCI, with omega-3 PUFAs being neuroprotective and omega-6 PUFAs having a damaging effect. Given the proven clinical safety of omega-3 PUFAs, our observations show that these PUFAs have significant therapeutic potential in SCI. In contrast, the use of preparations enriched in omega-6 PUFAs after injury could worsen outcome after SCI.

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