Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain

This data was imported from PubMed:

Authors: Dyall, S.C., Michael, G.J., Whelpton, R., Scott, A.G. and Michael-Titus, A.T.

Journal: Neurobiol Aging

Volume: 28

Issue: 3

Pages: 424-439

eISSN: 1558-1497

DOI: 10.1016/j.neurobiolaging.2006.01.002

Ageing is associated with a decrease in the brain content of omega-3 polyunsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and with decreased neuroplasticity. The glutamate receptor subunits GluR2 and NR2B play a significant role in forebrain synaptic plasticity. We investigated GluR2 and NR2B in the aged prefrontal cortex, hippocampus and striatum, and tested if treatment with a preparation containing EPA and DHA can reverse age-related changes. The study compared adult and old (3-4 and 24-26 month) rats, and the latter were fed a standard diet or a diet supplemented for 12 weeks with omega-3 PUFA at 270mg/kg/day (ratio EPA to DHA 1.5:1). Ageing was associated with decreases in the GluR2 and NR2B subunits in all structures. These decreases were fully reversed by omega-3 PUFA supplementation. Age-related changes in the phospholipid PUFA content were also seen. Decreases in DHA were mostly corrected by supplementation. This study supports the neuroprotective effect of omega-3 fatty acids in brain ageing, and illustrates specific mechanisms underlying this effect.

This source preferred by Simon Dyall

This data was imported from Scopus:

Authors: Dyall, S.C., Michael, G.J., Whelpton, R., Scott, A.G. and Michael-Titus, A.T.

Journal: Neurobiology of Aging

Volume: 28

Issue: 3

Pages: 424-439

ISSN: 0197-4580

DOI: 10.1016/j.neurobiolaging.2006.01.002

Ageing is associated with a decrease in the brain content of omega-3 polyunsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and with decreased neuroplasticity. The glutamate receptor subunits GluR2 and NR2B play a significant role in forebrain synaptic plasticity. We investigated GluR2 and NR2B in the aged prefrontal cortex, hippocampus and striatum, and tested if treatment with a preparation containing EPA and DHA can reverse age-related changes. The study compared adult and old (3-4 and 24-26 month) rats, and the latter were fed a standard diet or a diet supplemented for 12 weeks with omega-3 PUFA at 270 mg/kg/day (ratio EPA to DHA 1.5:1). Ageing was associated with decreases in the GluR2 and NR2B subunits in all structures. These decreases were fully reversed by omega-3 PUFA supplementation. Age-related changes in the phospholipid PUFA content were also seen. Decreases in DHA were mostly corrected by supplementation. This study supports the neuroprotective effect of omega-3 fatty acids in brain ageing, and illustrates specific mechanisms underlying this effect. © 2006 Elsevier Inc. All rights reserve d.

This data was imported from Web of Science (Lite):

Authors: Dyall, S.C., Michael, G.J., Whelpton, R., Scott, A.G. and Michael-Titus, A.T.

Journal: NEUROBIOLOGY OF AGING

Volume: 28

Issue: 3

Pages: 424-439

ISSN: 0197-4580

DOI: 10.1016/j.neurobiolaging.2006.01.002

This data was imported from Europe PubMed Central:

Authors: Dyall, S.C., Michael, G.J., Whelpton, R., Scott, A.G. and Michael-Titus, A.T.

Journal: Neurobiology of aging

Volume: 28

Issue: 3

Pages: 424-439

eISSN: 1558-1497

ISSN: 0197-4580

Ageing is associated with a decrease in the brain content of omega-3 polyunsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and with decreased neuroplasticity. The glutamate receptor subunits GluR2 and NR2B play a significant role in forebrain synaptic plasticity. We investigated GluR2 and NR2B in the aged prefrontal cortex, hippocampus and striatum, and tested if treatment with a preparation containing EPA and DHA can reverse age-related changes. The study compared adult and old (3-4 and 24-26 month) rats, and the latter were fed a standard diet or a diet supplemented for 12 weeks with omega-3 PUFA at 270mg/kg/day (ratio EPA to DHA 1.5:1). Ageing was associated with decreases in the GluR2 and NR2B subunits in all structures. These decreases were fully reversed by omega-3 PUFA supplementation. Age-related changes in the phospholipid PUFA content were also seen. Decreases in DHA were mostly corrected by supplementation. This study supports the neuroprotective effect of omega-3 fatty acids in brain ageing, and illustrates specific mechanisms underlying this effect.

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