A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility in Older Women: A Randomized, Double-blind, Placebo-controlled Pilot Study

Authors: Strike, S., Carlisle, A., Gibson, E.L. and Dyall, S.C.

http://eprints.bournemouth.ac.uk/22342/

Journal: J Gerontolog A Biol Sci Med Sci

DOI: 10.1093/gerona/glv109

This data was imported from PubMed:

Authors: Strike, S.C., Carlisle, A., Gibson, E.L. and Dyall, S.C.

http://eprints.bournemouth.ac.uk/22342/

Journal: J Gerontol A Biol Sci Med Sci

Volume: 71

Issue: 2

Pages: 236-242

eISSN: 1758-535X

DOI: 10.1093/gerona/glv109

BACKGROUND: Mobility is a key determinant of frailty in older persons, and a variety of dietary factors, such as the omega-3 fatty acid docosahexaenoic acid (DHA), are positively associated with decreased frailty and improved mobility and cognition in older persons. METHODS: The effects of a multinutrient supplement on mobility and cognition were assessed in postmenopausal women (60-84 years). Participants received either Efalex Active 50+ (1g DHA, 160 mg eicosapentaenoic acid, 240 mg Ginkgo biloba, 60 mg phosphatidylserine, 20mg d-α tocopherol, 1mg folic acid, and 20 µg vitamin B12 per day; N = 15) or placebo (N = 12) for 6 months. Mobility was assessed by VICON 9 motion capture camera system synchronized with Kistler force plates, cognitive performance by computerized cognitive function tests, and blood fatty acid levels by pin-prick analysis. RESULTS: Significant effects of treatment were seen in two of the four cognitive tests, with shorter mean latencies in a motor screening task (p < .05) and more words remembered (p < .03), and one of the three primary mobility measures with improved habitual walking speed (p < .05). Compared with the placebo group, supplementation also resulted in significantly higher blood DHA levels (p < .02). CONCLUSIONS: In this pilot study, multinutrient supplementation improved cognition and mobility in able older females at clinically relevant levels, suggesting a potential role in reducing the decline to frailty.

This data was imported from Scopus:

Authors: Strike, S.C., Carlisle, A., Gibson, E.L. and Dyall, S.C.

http://eprints.bournemouth.ac.uk/22342/

Journal: Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volume: 71

Issue: 2

Pages: 236-242

eISSN: 1758-535X

ISSN: 1079-5006

DOI: 10.1093/gerona/glv109

© 2015 The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. Background. Mobility is a key determinant of frailty in older persons, and a variety of dietary factors, such as the omega-3 fatty acid docosahexaenoic acid (DHA), are positively associated with decreased frailty and improved mobility and cognition in older persons. Methods. The effects of a multinutrient supplement on mobility and cognition were assessed in postmenopausal women (60-84 years). Participants received either Efalex Active 50+ (1g DHA, 160mg eicosapentaenoic acid, 240mg Ginkgo biloba, 60mg phosphatidylserine, 20mg d-α tocopherol, 1mg folic acid, and 20 μg vitamin B12 per day; N = 15) or placebo (N = 12) for 6 months. Mobility was assessed by VICON 9 motion capture camera system synchronized with Kistler force plates, cognitive performance by computerized cognitive function tests, and blood fatty acid levels by pin-prick analysis. Results. Significant effects of treatment were seen in two of the four cognitive tests, with shorter mean latencies in a motor screening task (p < . 05) and more words remembered (p < . 03), and one of the three primary mobility measures with improved habitual walking speed (p < . 05). Compared with the placebo group, supplementation also resulted in significantly higher blood DHA levels (p < . 02). Conclusions. In this pilot study, multinutrient supplementation improved cognition and mobility in able older females at clinically relevant levels, suggesting a potential role in reducing the decline to frailty.

This source preferred by Simon Dyall

This data was imported from Web of Science (Lite):

Authors: Strike, S.C., Carlisle, A., Gibson, E.L. and Dyall, S.C.

http://eprints.bournemouth.ac.uk/22342/

Journal: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Volume: 71

Issue: 2

Pages: 236-242

eISSN: 1758-535X

ISSN: 1079-5006

DOI: 10.1093/gerona/glv109

This data was imported from Europe PubMed Central:

Authors: Strike, S.C., Carlisle, A., Gibson, E.L. and Dyall, S.C.

http://eprints.bournemouth.ac.uk/22342/

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences

Volume: 71

Issue: 2

Pages: 236-242

eISSN: 1758-535X

ISSN: 1079-5006

Mobility is a key determinant of frailty in older persons, and a variety of dietary factors, such as the omega-3 fatty acid docosahexaenoic acid (DHA), are positively associated with decreased frailty and improved mobility and cognition in older persons.The effects of a multinutrient supplement on mobility and cognition were assessed in postmenopausal women (60-84 years). Participants received either Efalex Active 50+ (1g DHA, 160 mg eicosapentaenoic acid, 240 mg Ginkgo biloba, 60 mg phosphatidylserine, 20mg d-α tocopherol, 1mg folic acid, and 20 µg vitamin B12 per day; N = 15) or placebo (N = 12) for 6 months. Mobility was assessed by VICON 9 motion capture camera system synchronized with Kistler force plates, cognitive performance by computerized cognitive function tests, and blood fatty acid levels by pin-prick analysis.Significant effects of treatment were seen in two of the four cognitive tests, with shorter mean latencies in a motor screening task (p < .05) and more words remembered (p < .03), and one of the three primary mobility measures with improved habitual walking speed (p < .05). Compared with the placebo group, supplementation also resulted in significantly higher blood DHA levels (p < .02).In this pilot study, multinutrient supplementation improved cognition and mobility in able older females at clinically relevant levels, suggesting a potential role in reducing the decline to frailty.

The data on this page was last updated at 04:42 on September 20, 2017.