Absence of a normal Cortisol Awakening Response (CAR) in adolescent males with Asperger Syndrome (AS)
Authors: Brosnan, M., Turner-Cobb, J., Munro-Naan, Z. and Jessop, D.
Journal: Psychoneuroendocrinology
Volume: 34
Issue: 7
Pages: 1095-1100
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2009.02.011
Abstract:In addition to abnormalities in social and communication development, a 'need for sameness' and 'resistance to change' are features of autistic spectrum disorders first identified by Kanner in 1943. Our ability to react to change is modulated by the hypothalamic-pituitary-adrenal (HPA) axis, a feature of which is a dramatic increase in cortisol upon waking, the Cortisol Awakening Response (CAR). This study examined whether the CAR was evident in 20 adolescent males with Asperger Syndrome (AS) and 18 age-matched typically developing (TD) controls (aged 11-16). Whilst a significant CAR was evidenced in the TD control group, this was not the case for those with AS. A normal diurnal decrease in cortisol, however, was evident in both groups. The implication that individuals with AS may have an impaired response to change in their environment due to a refractory HPA axis is discussed. © 2009 Elsevier Ltd. All rights reserved.
Source: Scopus
Absence of a normal cortisol awakening response (CAR) in adolescent males with Asperger syndrome (AS).
Authors: Brosnan, M., Turner-Cobb, J., Munro-Naan, Z. and Jessop, D.
Journal: Psychoneuroendocrinology
Volume: 34
Issue: 7
Pages: 1095-1100
eISSN: 1873-3360
DOI: 10.1016/j.psyneuen.2009.02.011
Abstract:In addition to abnormalities in social and communication development, a 'need for sameness' and 'resistance to change' are features of autistic spectrum disorders first identified by Kanner in 1943. Our ability to react to change is modulated by the hypothalamic-pituitary-adrenal (HPA) axis, a feature of which is a dramatic increase in cortisol upon waking, the Cortisol Awakening Response (CAR). This study examined whether the CAR was evident in 20 adolescent males with Asperger Syndrome (AS) and 18 age-matched typically developing (TD) controls (aged 11-16). Whilst a significant CAR was evidenced in the TD control group, this was not the case for those with AS. A normal diurnal decrease in cortisol, however, was evident in both groups. The implication that individuals with AS may have an impaired response to change in their environment due to a refractory HPA axis is discussed.
Source: PubMed
Absence of a normal Cortisol Awakening Response (CAR) in adolescent mates with Asperger Syndrome (AS)
Authors: Brosnan, M., Turner-Cobb, J., Munro-Naan, Z. and Jessop, D.
Journal: PSYCHONEUROENDOCRINOLOGY
Volume: 34
Issue: 7
Pages: 1095-1100
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2009.02.011
Source: Web of Science (Lite)
Absence of a normal Cortisol Awakening Response (CAR) in adolescent males with Asperger Syndrome (AS)
Authors: Brosnan, M., Turner-Cobb, J., Munro-Naan, Z. and Jessop, D.
Journal: Psychoneuroendocrinology
Volume: 34
Issue: 7
Pages: 1095-1100
DOI: 10.1016/j.psyneuen.2009.02.011
Source: Manual
Absence of a normal cortisol awakening response (CAR) in adolescent males with Asperger syndrome (AS).
Authors: Brosnan, M., Turner-Cobb, J., Munro-Naan, Z. and Jessop, D.
Journal: Psychoneuroendocrinology
Volume: 34
Issue: 7
Pages: 1095-1100
eISSN: 1873-3360
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2009.02.011
Abstract:In addition to abnormalities in social and communication development, a 'need for sameness' and 'resistance to change' are features of autistic spectrum disorders first identified by Kanner in 1943. Our ability to react to change is modulated by the hypothalamic-pituitary-adrenal (HPA) axis, a feature of which is a dramatic increase in cortisol upon waking, the Cortisol Awakening Response (CAR). This study examined whether the CAR was evident in 20 adolescent males with Asperger Syndrome (AS) and 18 age-matched typically developing (TD) controls (aged 11-16). Whilst a significant CAR was evidenced in the TD control group, this was not the case for those with AS. A normal diurnal decrease in cortisol, however, was evident in both groups. The implication that individuals with AS may have an impaired response to change in their environment due to a refractory HPA axis is discussed.
Source: Europe PubMed Central