Absence of a normal Cortisol Awakening Response (CAR) in adolescent males with Asperger Syndrome (AS)

Authors: Brosnan, M., Turner-Cobb, J., Munro-Naan, Z. and Jessop, D.

Journal: Psychoneuroendocrinology

Volume: 34

Issue: 7

Pages: 1095-1100

ISSN: 0306-4530

DOI: 10.1016/j.psyneuen.2009.02.011

Abstract:

In addition to abnormalities in social and communication development, a 'need for sameness' and 'resistance to change' are features of autistic spectrum disorders first identified by Kanner in 1943. Our ability to react to change is modulated by the hypothalamic-pituitary-adrenal (HPA) axis, a feature of which is a dramatic increase in cortisol upon waking, the Cortisol Awakening Response (CAR). This study examined whether the CAR was evident in 20 adolescent males with Asperger Syndrome (AS) and 18 age-matched typically developing (TD) controls (aged 11-16). Whilst a significant CAR was evidenced in the TD control group, this was not the case for those with AS. A normal diurnal decrease in cortisol, however, was evident in both groups. The implication that individuals with AS may have an impaired response to change in their environment due to a refractory HPA axis is discussed. © 2009 Elsevier Ltd. All rights reserved.

Source: Scopus

Absence of a normal cortisol awakening response (CAR) in adolescent males with Asperger syndrome (AS).

Authors: Brosnan, M., Turner-Cobb, J., Munro-Naan, Z. and Jessop, D.

Journal: Psychoneuroendocrinology

Volume: 34

Issue: 7

Pages: 1095-1100

eISSN: 1873-3360

DOI: 10.1016/j.psyneuen.2009.02.011

Abstract:

In addition to abnormalities in social and communication development, a 'need for sameness' and 'resistance to change' are features of autistic spectrum disorders first identified by Kanner in 1943. Our ability to react to change is modulated by the hypothalamic-pituitary-adrenal (HPA) axis, a feature of which is a dramatic increase in cortisol upon waking, the Cortisol Awakening Response (CAR). This study examined whether the CAR was evident in 20 adolescent males with Asperger Syndrome (AS) and 18 age-matched typically developing (TD) controls (aged 11-16). Whilst a significant CAR was evidenced in the TD control group, this was not the case for those with AS. A normal diurnal decrease in cortisol, however, was evident in both groups. The implication that individuals with AS may have an impaired response to change in their environment due to a refractory HPA axis is discussed.

Source: PubMed

Absence of a normal Cortisol Awakening Response (CAR) in adolescent mates with Asperger Syndrome (AS)

Authors: Brosnan, M., Turner-Cobb, J., Munro-Naan, Z. and Jessop, D.

Journal: PSYCHONEUROENDOCRINOLOGY

Volume: 34

Issue: 7

Pages: 1095-1100

ISSN: 0306-4530

DOI: 10.1016/j.psyneuen.2009.02.011

Source: Web of Science (Lite)

Absence of a normal Cortisol Awakening Response (CAR) in adolescent males with Asperger Syndrome (AS)

Authors: Brosnan, M., Turner-Cobb, J., Munro-Naan, Z. and Jessop, D.

Journal: Psychoneuroendocrinology

Volume: 34

Issue: 7

Pages: 1095-1100

DOI: 10.1016/j.psyneuen.2009.02.011

Source: Manual

Absence of a normal cortisol awakening response (CAR) in adolescent males with Asperger syndrome (AS).

Authors: Brosnan, M., Turner-Cobb, J., Munro-Naan, Z. and Jessop, D.

Journal: Psychoneuroendocrinology

Volume: 34

Issue: 7

Pages: 1095-1100

eISSN: 1873-3360

ISSN: 0306-4530

DOI: 10.1016/j.psyneuen.2009.02.011

Abstract:

In addition to abnormalities in social and communication development, a 'need for sameness' and 'resistance to change' are features of autistic spectrum disorders first identified by Kanner in 1943. Our ability to react to change is modulated by the hypothalamic-pituitary-adrenal (HPA) axis, a feature of which is a dramatic increase in cortisol upon waking, the Cortisol Awakening Response (CAR). This study examined whether the CAR was evident in 20 adolescent males with Asperger Syndrome (AS) and 18 age-matched typically developing (TD) controls (aged 11-16). Whilst a significant CAR was evidenced in the TD control group, this was not the case for those with AS. A normal diurnal decrease in cortisol, however, was evident in both groups. The implication that individuals with AS may have an impaired response to change in their environment due to a refractory HPA axis is discussed.

Source: Europe PubMed Central