The Release of Basic Drugs by the Enzymic Digestion of Tissues in Cases of Poisoning

Authors: Osselton, M.D.

Journal: Journal of the Forensic Science Society

Volume: 17

Issue: 2-3

Pages: 189-194

ISSN: 0015-7368

DOI: 10.1016/S0015-7368(77)71147-8

Abstract:

The proteolytic enzyme subtilisin Carlsberg has been used to digest human livers containing a variety of basic drugs. Results of subsequent drug analysis showed that greatly increased levels of these drugs were released compared with degradation using conventional acid hydrolysis procedures. An analytical procedure is proposed for use in forensic case work for the isolation of basic drugs, unchanged benzodiazepines and drug metabolites in high yield from a single liver digest. © 1977, Forensic Science Society. All rights reserved.

Source: Scopus

The release of basic drugs by the enzymic digestion of tissues in cases of poisoning.

Authors: Osselton, M.D.

Journal: J Forensic Sci Soc

Volume: 17

Issue: 2-3

Pages: 189-194

ISSN: 0015-7368

DOI: 10.1016/s0015-7368(77)71147-8

Source: PubMed

Preferred by: David Osselton

The release of basic drugs by the enzymic digestion of tissues in cases of poisoning.

Authors: Osselton, M.D.

Journal: Journal - Forensic Science Society

Volume: 17

Issue: 2-3

Pages: 189-194

eISSN: 1876-4282

ISSN: 0015-7368

DOI: 10.1016/s0015-7368(77)71147-8

Source: Europe PubMed Central