The Release of Basic Drugs by the Enzymic Digestion of Tissues in Cases of Poisoning
Authors: Osselton, M.D.
Journal: Journal of the Forensic Science Society
Volume: 17
Issue: 2-3
Pages: 189-194
ISSN: 0015-7368
DOI: 10.1016/S0015-7368(77)71147-8
Abstract:The proteolytic enzyme subtilisin Carlsberg has been used to digest human livers containing a variety of basic drugs. Results of subsequent drug analysis showed that greatly increased levels of these drugs were released compared with degradation using conventional acid hydrolysis procedures. An analytical procedure is proposed for use in forensic case work for the isolation of basic drugs, unchanged benzodiazepines and drug metabolites in high yield from a single liver digest. © 1977, Forensic Science Society. All rights reserved.
Source: Scopus
The release of basic drugs by the enzymic digestion of tissues in cases of poisoning.
Authors: Osselton, M.D.
Journal: J Forensic Sci Soc
Volume: 17
Issue: 2-3
Pages: 189-194
ISSN: 0015-7368
DOI: 10.1016/s0015-7368(77)71147-8
Source: PubMed
Preferred by: David Osselton
The release of basic drugs by the enzymic digestion of tissues in cases of poisoning.
Authors: Osselton, M.D.
Journal: Journal - Forensic Science Society
Volume: 17
Issue: 2-3
Pages: 189-194
eISSN: 1876-4282
ISSN: 0015-7368
DOI: 10.1016/s0015-7368(77)71147-8
Source: Europe PubMed Central