Enzymic digestion of liver tissue to release barbiturates, salicylic acid and other acidic compounds in cases of human poisoning
Authors: Osselton, M.D., Shaw, I.C. and Stevens, H.M.
Journal: The Analyst
Volume: 103
Issue: 1232
Pages: 1160-1164
ISSN: 0003-2654
DOI: 10.1039/AN9780301160
Abstract:The proteolytic enzyme subtilisin Carlsberg has been used to digest human liver tissues containing barbiturates, salicylic acid and a mixture of 2,4-dichlorophenoxyacetic and 2,4-dichlorophenoxypropionic acids. The levels of the drugs released by this method were significantly higher than those measured by using conventional procedures for tissue degradation. The enzymic digestion of tissues is easy to manipulate, yields reproducible results and is inexpensive.
Source: Scopus
Enzymic digestion of liver tissue to release barbiturates, salicylic acid and other acidic compounds in cases of human poisoning.
Authors: Osselton, M.D., Shaw, I.C. and Stevens, H.M.
Journal: Analyst
Volume: 103
Issue: 1232
Pages: 1160-1164
ISSN: 0003-2654
DOI: 10.1039/an9780301160
Source: PubMed
Preferred by: David Osselton
Enzymic digestion of liver tissue to release barbiturates, salicylic acid and other acidic compounds in cases of human poisoning.
Authors: Osselton, M.D., Shaw, I.C. and Stevens, H.M.
Journal: The Analyst
Volume: 103
Issue: 1232
Pages: 1160-1164
eISSN: 1364-5528
ISSN: 0003-2654
DOI: 10.1039/an9780301160
Source: Europe PubMed Central