Gas-liquid chromatographic retention indices of 296 non-drug substances on SE-30 or OV-1 likely to be encountered in toxicological analyses
Authors: Ramsey, J.D., Lee, T.D., Osselton, M.D. and Moffat, A.C.
Journal: Journal of Chromatography A
Volume: 184
Issue: 2
Pages: 185-206
ISSN: 0021-9673
DOI: 10.1016/S0021-9673(00)85641-1
Abstract:The advent of the widespread use of selective detectors (electron capture detector, phosphorus/nitrogen detector) for gas-liquid chromatography used in toxicological analyses has revealed the presence of hitherto unseen interfering materials. These substances may be conveniently grouped into (1), anti-oxidants; (2), putrefactive and endogenous compounds; (3), pesticides; (4), food additives, flavours and fragrances; (5) plasticisers, plastic additives and vulcanising agents and (6), scintillation reagents. To facilitate the identification of these materials, retention indices on the dimethyl silicone phases SE-30 or OV-1 have been compiled by the two laboratories to include 296 such compounds. Most gave single peaks, but some gave complex patterns indicating that they were mixtures of compounds. Of the 296 compounds, 14 did not give observable peaks, 8 gave 2 or 3 peaks and 44 gave more than 3 peaks. To determine the interlaboratory difference between retention index measurements, 17 compounds were chromatographed by both laboratories: the mean difference was ± 13 retention index units with only one greater than ± 50 retention index units. Examples of how these materials may be encountered during toxicological analyses are given. Data are also presented on compounds which have been used as internal standards. © 1980.
Source: Scopus
Gas--liquid chromatographic retention indices of 296 non-drug substances on SE-30 or OV-1 likely to be encountered in toxicological analyses.
Authors: Ramsey, J.D., Lee, T.D., Osselton, M.D. and Moffat, A.C.
Journal: J Chromatogr
Volume: 184
Issue: 2
Pages: 185-206
DOI: 10.1016/s0021-9673(00)85641-1
Abstract:The advent of the widespread use of selective detectors (electron capture detector, phosphorus/nitrogen dectector) for gas--liquid chromatography used in toxicological analyses has revealed the presence of hitherto unseen interfering materials. These substances may be conveniently grouped into (1), anti-oxidants; (2), putrefactive and endogenous compounds; (3), pesticides; (4), food additives, flavours and fragrances; (5) plasticisers, plastic additives and vulcanising agents and (6), scintillation reagents. To facilitate the identification of these materials, retention indices on the dimethyl silicone phases SE-30 or OV-1 have been compiled by the two laboratories to include 296 such compounds. Most gave single peaks, but some gave complex patterns indicating that they were mixtures of compounds. Of the 296 compounds, 14 did not give observable peaks, 8 gave 2 or 3 peaks and 44 gave more than 3 peaks. To determine the interlaboratory difference between retention index measurements, 17 compounds were chromatographed by both laboratories: the mean difference was +/- 13 retention index units with only one greater than +/- 50 retention index units. Examples of how these materials may be encountered during toxicological analyses are given. Data are also presented on compounds which have been used as internal standards.
Source: PubMed
Preferred by: David Osselton
Gas--liquid chromatographic retention indices of 296 non-drug substances on SE-30 or OV-1 likely to be encountered in toxicological analyses.
Authors: Ramsey, J.D., Lee, T.D., Osselton, M.D. and Moffat, A.C.
Journal: Journal of chromatography
Volume: 184
Issue: 2
Pages: 185-206
DOI: 10.1016/s0021-9673(00)85641-1
Abstract:The advent of the widespread use of selective detectors (electron capture detector, phosphorus/nitrogen dectector) for gas--liquid chromatography used in toxicological analyses has revealed the presence of hitherto unseen interfering materials. These substances may be conveniently grouped into (1), anti-oxidants; (2), putrefactive and endogenous compounds; (3), pesticides; (4), food additives, flavours and fragrances; (5) plasticisers, plastic additives and vulcanising agents and (6), scintillation reagents. To facilitate the identification of these materials, retention indices on the dimethyl silicone phases SE-30 or OV-1 have been compiled by the two laboratories to include 296 such compounds. Most gave single peaks, but some gave complex patterns indicating that they were mixtures of compounds. Of the 296 compounds, 14 did not give observable peaks, 8 gave 2 or 3 peaks and 44 gave more than 3 peaks. To determine the interlaboratory difference between retention index measurements, 17 compounds were chromatographed by both laboratories: the mean difference was +/- 13 retention index units with only one greater than +/- 50 retention index units. Examples of how these materials may be encountered during toxicological analyses are given. Data are also presented on compounds which have been used as internal standards.
Source: Europe PubMed Central