Caffeine restores regional brain activation in acute hypoglycaemia in healthy volunteers

Authors: Rosenthal, M.J., Smith, D., Yaguez, L., Giampietro, V., Kerr, D., Bullmore, E., Brammer, M., Williams, S.C.R. and Amiel, S.A.

Journal: Diabetic Medicine

Volume: 24

Issue: 7

Pages: 720-727

eISSN: 1464-5491

ISSN: 0742-3071

DOI: 10.1111/j.1464-5491.2007.02131.x

Abstract:

Aims: Caffeine enhances counterregulatory responses to acute hypoglycaemia. Our aim was to explore its effects on cortical function, which are not known at present. Methods: Regional brain activation during performance of the four-choice reaction time (4CRT) at different levels of complexity was measured using functional magnetic resonance imaging (fMRI) at euglycaemia (5 mmol/l) and hypoglycaemia (2.6 mmol/l) in the presence and absence of caffeine in six healthy right-handed men. Results: During hypoglycaemia, caffeine enhanced adrenaline responses to hypoglycaemia (2.5 ± 0.7 nmol/l to 4.0 ± 1.0 nmol/l, P = 0.01) and restored the brain activation response to the non-cued 4CRT, the linear increases in regional brain activation associated with increased task complexity and the ability to respond to a cue that were lost in hypoglycaemia alone. Conclusions: Caffeine can sustain regional brain activation patterns lost in acute hypoglycaemia, with some restoration of cortical function and enhanced adrenaline responsiveness. A methodology has been established that may help in the development of therapies to protect against severe hypoglycaemia in insulin therapy for patients with diabetes and problematic hypoglycaemia. © 2007 The Authors.

Source: Scopus

Caffeine restores regional brain activation in acute hypoglycaemia in healthy volunteers.

Authors: Rosenthal, M.J., Smith, D., Yaguez, L., Giampietro, V., Kerr, D., Bullmore, E., Brammer, M., Williams, S.C.R. and Amiel, S.A.

Journal: Diabet Med

Volume: 24

Issue: 7

Pages: 720-727

ISSN: 0742-3071

DOI: 10.1111/j.1464-5491.2007.02131.x

Abstract:

AIMS: Caffeine enhances counterregulatory responses to acute hypoglycaemia. Our aim was to explore its effects on cortical function, which are not known at present. METHODS: Regional brain activation during performance of the four-choice reaction time (4CRT) at different levels of complexity was measured using functional magnetic resonance imaging (fMRI) at euglycaemia (5 mmol/l) and hypoglycaemia (2.6 mmol/l) in the presence and absence of caffeine in six healthy right-handed men. RESULTS: During hypoglycaemia, caffeine enhanced adrenaline responses to hypoglycaemia (2.5 +/- 0.7 nmol/l to 4.0 +/- 1.0 nmol/l, P = 0.01) and restored the brain activation response to the non-cued 4CRT, the linear increases in regional brain activation associated with increased task complexity and the ability to respond to a cue that were lost in hypoglycaemia alone. CONCLUSIONS: Caffeine can sustain regional brain activation patterns lost in acute hypoglycaemia, with some restoration of cortical function and enhanced adrenaline responsiveness. A methodology has been established that may help in the development of therapies to protect against severe hypoglycaemia in insulin therapy for patients with diabetes and problematic hypoglycaemia.

Source: PubMed

Caffeine restores regional brain activation in acute hypoglycaemia in healthy volunteers

Authors: Rosenthal, M.J., Smith, D., Yaguez, L., Giampietro, V., Kerr, D., Bullmore, E., Brammer, M., Williams, S.C.R. and Amiel, S.A.

Journal: DIABETIC MEDICINE

Volume: 24

Issue: 7

Pages: 720-727

eISSN: 1464-5491

ISSN: 0742-3071

DOI: 10.1111/j.1464-5491.2007.02131.x

Source: Web of Science (Lite)

Caffeine restores regional brain activation in acute hypoglycaemia in healthy volunteers

Authors: Rosenthal, M.J., Smith, D., Yaguez, L., Giampietro, V., Kerr, D., Bullmore, E., Brammer, M., Williams, S.C.R. and Amiel, S.A.

Journal: Diabetic Medicine

Volume: 24

Pages: 720-727

ISSN: 0742-3071

DOI: 10.1111/j.1464-5491.2007.02131.x

Abstract:

Aims Caffeine enhances counterregulatory responses to acute hypoglycaemia. Our aim was to explore its effects on cortical function, which are not known at present.

Methods Regional brain activation during performance of the four-choice reaction time (4CRT) at different levels of complexity was measured using functional magnetic resonance imaging (fMRI) at euglycaemia (5 mmol/l) and hypoglycaemia (2.6 mmol/l) in the presence and absence of caffeine in six healthy right-handed men.

Results During hypoglycaemia, caffeine enhanced adrenaline responses to hypoglycaemia (2.5 ± 0.7 nmol/l to 4.0 ± 1.0 nmol/l, P = 0.01) and restored the brain activation response to the non-cued 4CRT, the linear increases in regional brain activation associated with increased task complexity and the ability to respond to a cue that were lost in hypoglycaemia alone.

Conclusions Caffeine can sustain regional brain activation patterns lost in acute hypoglycaemia, with some restoration of cortical function and enhanced adrenaline responsiveness. A methodology has been established that may help in the development of therapies to protect against severe hypoglycaemia in insulin therapy for patients with diabetes and problematic hypoglycaemia.

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1464-5491.2007.02131.x

Source: Manual

Preferred by: David Kerr

Caffeine restores regional brain activation in acute hypoglycaemia in healthy volunteers.

Authors: Rosenthal, M.J., Smith, D., Yaguez, L., Giampietro, V., Kerr, D., Bullmore, E., Brammer, M., Williams, S.C.R. and Amiel, S.A.

Journal: Diabetic medicine : a journal of the British Diabetic Association

Volume: 24

Issue: 7

Pages: 720-727

eISSN: 1464-5491

ISSN: 0742-3071

DOI: 10.1111/j.1464-5491.2007.02131.x

Abstract:

Aims

Caffeine enhances counterregulatory responses to acute hypoglycaemia. Our aim was to explore its effects on cortical function, which are not known at present.

Methods

Regional brain activation during performance of the four-choice reaction time (4CRT) at different levels of complexity was measured using functional magnetic resonance imaging (fMRI) at euglycaemia (5 mmol/l) and hypoglycaemia (2.6 mmol/l) in the presence and absence of caffeine in six healthy right-handed men.

Results

During hypoglycaemia, caffeine enhanced adrenaline responses to hypoglycaemia (2.5 +/- 0.7 nmol/l to 4.0 +/- 1.0 nmol/l, P = 0.01) and restored the brain activation response to the non-cued 4CRT, the linear increases in regional brain activation associated with increased task complexity and the ability to respond to a cue that were lost in hypoglycaemia alone.

Conclusions

Caffeine can sustain regional brain activation patterns lost in acute hypoglycaemia, with some restoration of cortical function and enhanced adrenaline responsiveness. A methodology has been established that may help in the development of therapies to protect against severe hypoglycaemia in insulin therapy for patients with diabetes and problematic hypoglycaemia.

Source: Europe PubMed Central