Randomized control trial investigating the influence of coffee on heart rate variability in patients with ST-segment elevation myocardial infarction

Authors: Richardson, T., Baker, J., Thomas, P.W., Meckes, C., Rozkovec, A. and Kerr, D.

Journal: QJM: An International Journal of Medicine

Volume: 102

Issue: 8

Pages: 555-561

eISSN: 1460-2393

ISSN: 1460-2725

DOI: 10.1093/qjmed/hcp072

Abstract:

Background: Cardiac autonomic dysfunction post ST-segment elevation myocardial infarction (STEMI) has been linked to an excess risk of premature cardiovascular morbidity and mortality above those with normal autonomic function post-STEMI. Aim: The aim of this study was to evaluate the effect of acute ingestion of coffee on autonomic function and cardiovascular outcomes in patients with acute STEMI. Design: Randomized control trial. Methods: We randomized 103 patients with acute STEMI, admitted to our Coronary Care Unit, to receive regular coffee (caffeinated) or de-caffeinated coffee using a randomized controlled double-blinded design. Heart rate variability was assessed 5 days post-STEMI to assess the effect of caffeine on autonomic function. Results: In the group randomized to regular coffee, parasympathetic activity increased by up to 96% (P = 0.04) after 5 days. There was no detrimental effect of regular coffee on cardiac rhythm post-STEMI. Conclusion: Coffee ingestion is associated with an increase in parasympathetic autonomic function immediately post-STEMI. Coffee was found to be safe and not associated with any adverse cardiovascular outcomes in the short term. © The Author 2009. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved.

Source: Scopus

Randomized control trial investigating the influence of coffee on heart rate variability in patients with ST-segment elevation myocardial infarction.

Authors: Richardson, T., Baker, J., Thomas, P.W., Meckes, C., Rozkovec, A. and Kerr, D.

Journal: QJM

Volume: 102

Issue: 8

Pages: 555-561

eISSN: 1460-2393

DOI: 10.1093/qjmed/hcp072

Abstract:

BACKGROUND: Cardiac autonomic dysfunction post ST-segment elevation myocardial infarction (STEMI) has been linked to an excess risk of premature cardiovascular morbidity and mortality above those with normal autonomic function post-STEMI. AIM: The aim of this study was to evaluate the effect of acute ingestion of coffee on autonomic function and cardiovascular outcomes in patients with acute STEMI. DESIGN: Randomized control trial. METHODS: We randomized 103 patients with acute STEMI, admitted to our Coronary Care Unit, to receive regular coffee (caffeinated) or de-caffeinated coffee using a randomized controlled double-blinded design. Heart rate variability was assessed 5 days post-STEMI to assess the effect of caffeine on autonomic function. RESULTS: In the group randomized to regular coffee, parasympathetic activity increased by up to 96% (P = 0.04) after 5 days. There was no detrimental effect of regular coffee on cardiac rhythm post-STEMI. CONCLUSION: Coffee ingestion is associated with an increase in parasympathetic autonomic function immediately post-STEMI. Coffee was found to be safe and not associated with any adverse cardiovascular outcomes in the short term.

Source: PubMed

Randomized control trial investigating the influence of coffee on heart rate variability in patients with ST-segment elevation myocardial infarction

Authors: Richardson, T., Baker, J., Thomas, P.W., Meckes, C., Rozkovec, A. and Kerr, D.

Journal: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Volume: 102

Issue: 8

Pages: 555-561

eISSN: 1460-2393

ISSN: 1460-2725

DOI: 10.1093/qjmed/hcp072

Source: Web of Science (Lite)

Randomized control trial investigating the influence of coffee on heart rate variability in patients with ST-segment elevation myocardial infarction

Authors: Richardson, T., Baker, J., Thomas, P.W., Meckes, C., Rozkovec, A. and Kerr, D.

Journal: Quarterly Journal of Medicine

Volume: 102

Pages: 555-561

ISSN: 1460-2725

DOI: 10.1093/qjmed/hcp072

Abstract:

Background: Cardiac autonomic dysfunction post ST-segment elevation myocardial infarction (STEMI) has been linked to an excess risk of premature cardiovascular morbidity and mortality above those with normal autonomic function post-STEMI. Aim: The aim of this study was to evaluate the effect of acute ingestion of coffee on autonomic function and cardiovascular outcomes in patients with acute STEMI. Design: Randomized control trial. Methods: We randomized 103 patients with acute STEMI, admitted to our Coronary Care Unit, to receive regular coffee (caffeinated) or de-caffeinated coffee using a randomized controlled double-blinded design. Heart rate variability was assessed 5 days post-STEMI to assess the effect of caffeine on autonomic function. Results: In the group randomized to regular coffee, parasympathetic activity increased by up to 96% (P = 0.04) after 5 days. There was no detrimental effect of regular coffee on cardiac rhythm post-STEMI. Conclusion: Coffee ingestion is associated with an increase in parasympathetic autonomic function immediately post-STEMI. Coffee was found to be safe and not associated with any adverse cardiovascular outcomes in the short term

Source: Manual

Preferred by: David Kerr

Randomized control trial investigating the influence of coffee on heart rate variability in patients with ST-segment elevation myocardial infarction.

Authors: Richardson, T., Baker, J., Thomas, P.W., Meckes, C., Rozkovec, A. and Kerr, D.

Journal: QJM : monthly journal of the Association of Physicians

Volume: 102

Issue: 8

Pages: 555-561

eISSN: 1460-2393

ISSN: 1460-2725

DOI: 10.1093/qjmed/hcp072

Abstract:

Background

Cardiac autonomic dysfunction post ST-segment elevation myocardial infarction (STEMI) has been linked to an excess risk of premature cardiovascular morbidity and mortality above those with normal autonomic function post-STEMI.

Aim

The aim of this study was to evaluate the effect of acute ingestion of coffee on autonomic function and cardiovascular outcomes in patients with acute STEMI.

Design

Randomized control trial.

Methods

We randomized 103 patients with acute STEMI, admitted to our Coronary Care Unit, to receive regular coffee (caffeinated) or de-caffeinated coffee using a randomized controlled double-blinded design. Heart rate variability was assessed 5 days post-STEMI to assess the effect of caffeine on autonomic function.

Results

In the group randomized to regular coffee, parasympathetic activity increased by up to 96% (P = 0.04) after 5 days. There was no detrimental effect of regular coffee on cardiac rhythm post-STEMI.

Conclusion

Coffee ingestion is associated with an increase in parasympathetic autonomic function immediately post-STEMI. Coffee was found to be safe and not associated with any adverse cardiovascular outcomes in the short term.

Source: Europe PubMed Central