Dr Kevin McGhee
- 01202 968189
- kmcghee at bournemouth dot ac dot uk
- Acting Deputy Dean- Education & Professional Practice
- Christchurch House C230, Talbot Campus, Fern Barrow, Poole, BH12 5BB
- Dr Derek Morris, Cognitive Genetics Group at NUI Galway
- Dr Jehannine Austin, University of British Columbia
- Manchester Fly Facility
- Psychiatric Genetic Counselling
- Psychiatric Genetic Counselling Resource
- Translational Genetics@BU
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I am currently the Acting Deputy Dean Education & Professional Practice for the Faculty of Science & Technology. I am also an Associate Professor in Health Sciences.
I have a BSc (Hons) in Biomedical Sciences from the University of Paisley, Scotland during which, I was awarded a Leonardo da Vinci scholarship in 1999 to work at the NAVBC University College Dublin, Ireland. After completing my degree, I returned to Ireland to undertake a Health Research Board funded PhD in Psychiatric Genetics at Trinity College Dublin, Ireland. My supervisors were Professor Michael Gill and Professor Aiden Corvin, Psychiatry, TCD.
In 2006, I moved to the University of Edinburgh for post-doctoral work under the supervision of Professor Douglas Blackwood, Division of Psychiatry. I was based in the laboratory of Professor David Porteous (Medical Genetics), at the Molecular Medicine Centre. The post was funded during my time there by Generation Scotland, the Chief Scientist's Office (Scotland), Organon and Wyeth...
It provided many opportunities for international collaboration: the Broad Institute (MIT and Harvard, USA); the University of North Carolina (USA); and the Centre for Molecular Medicine and Therapeutics at the University of British Columbia (Vancouver, Canada) as well as my membership of the International Schizophrenia Consortium.
My second post-doctoral position was under Professor Ian Deary (Psychology, University of Edinburgh) investigating the genetics of cognitive ageing funded by a BBSRC grant and provided opportunity for collaboration with the University of Manchester.
Prior to joining BU I briefly held a Teaching Fellow's post in Nursing Studies (Biology) at the University of Edinburgh under Dr Jenny Tocher and spent three years as a part time lecturer in Human Biology (concurrent with my PhD studies) within the School of Nursing and Midwifery at Trinity College Dublin (under Dr Gabrielle McKee).more
I lead a Translational Genetics research group investigating two main areas: psychiatric genetic counselling & functional genetics. We have two main questions:
1) How do genes exert their biological function and interact with environmental factors known to be important in mental health?
2) How can we translate this complex population level data into benefit for an individual?
To answer the first question, we data mine DNA results from the International Schizophrenia Consortium using computational methods to identify statistically significant candidate genes, then investigate what the function of these genes are using Fruit Flies as the simple model organism.
To answer the second question, it requires a change in the mind set of health professionals, patients, their families and the general public. Therefore to inform public and healthcare professionals accordingly, we are conducting the UK's first pilot Psychiatric Genetic Counselling clinic in Dorset to gauge the potential benefit to patients.
I am currently funded as the Principal Investigator on a £33,600 HEIF 5+1+1 grant titled “Empowering service users: Assessing the potential benefits of Psychiatric Genetic Counselling” having previously been awarded £60,000 (HEIF 5+1) in 2015/16, £80,000 in 2014/15 from two Fusion Investment Fund grants and a UK/Canada travel award of £1250 from the Foreign & Commonwealth Office.
I work with many co-investigators, listed through the various website links above, but have consistently worked with Dr Jehannine Austin (Visiting Fellow BU and Associate Professor, University of British Columbia, Vancouver, Canada)...
Throughout these projects, we encourage the co-creation and co-production of scientific knowledge through student led projects generating skilled graduates able to translate complex genetics into real meaning for individuals.more
- Maier, R. et al., 2015. Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. American Journal of Human Genetics, 96 (2), 283-294.
- O'Dushlaine, C., McGhee, K.A. et al., 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. NATURE NEUROSCIENCE, 18 (2), 199-209.
- Lee, S.H., McGhee, K.A. et al., 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. NATURE GENETICS, 45 (9), 984-+.
- Schork, A.J. et al., 2013. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet, 9 (4), e1003449.
- Cross-Disorder Group of the Psychiatric Genomics Consortium, Smoller JW, Craddock N, Kendler K, Lee PH, Neale BM, Nurnberger JI, Ripke S, Santangelo S, Sullivan PF., 2013. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet.
- Terwisscha van Scheltinga AF, Bakker SC, van Haren NE, Derks EM, Buizer-Voskamp JE, Boos HB, Cahn W, Hulshoff Pol HE, Ripke S, Ophoff RA, Kahn RS; Psychiatric Genome-wide Association Study Consortium, 2013. Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biological Psychiatry.
- Jia P, Wang L, Fanous AH, Pato CN, Edwards TL; International Schizophrenia Consortium, Zhao Z., 2012. Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia. PLoS Computational Biology.
- Derks EM, Vorstman JA, Ripke S, Kahn RS; Schizophrenia Psychiatric Genomic Consortium, Ophoff RA., 2012. Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis. PLoS One.
- Keller MC, Simonson MA, Ripke S, Neale BM, Gejman PV, Howrigan DP, Lee SH, Lencz T, Levinson DF, Sullivan PF; Schizophrenia Psychiatric Genome-Wide Association Study Consortium., 2012. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. PLoS Genetics.
- Jia P, Wang L, Fanous AH, Chen X, Kendler KS; International Schizophrenia Consortium, Zhao Z., 2012. A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. Journal of Medical Genetics.
- Richards AL, Jones L, Moskvina V, Kirov G, Gejman PV, Levinson DF, Sanders AR; Molecular Genetics of Schizophrenia Collaboration (MGS); International Schizophrenia Consortium (ISC), Purcell S, Visscher PM, Craddock N, Owen MJ, Holmans P, O'Donovan MC., 2012. Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Molecular Psychaitry, Feb17(2):, 193-201.
- Chen, X. et al., 2011. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Molecular Psychiatry, 16 (11), 1117-1129.
- Davies, G., McGhee, K. et al., 2011. Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry, 16 (10), 996-1005.
- Ripke, S. et al., 2011. Genome-wide association study identifies five new schizophrenia loci. Nature Genetics, 43 (10), 969-978.
- Sklar, P. et al., 2011. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nature Genetics, 43 (10), 977-985.
- Chen, J., Lee, G., Fanous, A.H., Zhao, Z., Jia, P., O'Neill, A., Walsh, D., Kendler, K.S., Chen, X. and International Schizophrenia Consortium, 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophr Res, 131 (1-3), 43-51.
- Luciano, M., McGhee, K.A. et al., 2011. Whole genome association scan for genetic polymorphisms influencing information processing speed. Biol Psychol, 86 (3), 193-202.
- Chen J, Lee G, Fanous AH, Zhao Z, Jia P, O'Neill A, Walsh D, Kendler KS, Chen X; International Schizophrenia Consortium., 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research.
- Bridges M, Heron EA, O'Dushlaine C, Segurado R; International Schizophrenia Consortium (ISC), Morris D, Corvin A, Gill M, Pinto C., 2011. Genetic classification of populations using supervised learning. PLoS One.
- Raychaudhuri, S., McGhee, K. et al., 2010. Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genetics, 6 (9).
- Houlihan, L.M., McGhee, K.A. et al., 2010. Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time. American Journal of Human Genetics, 86, 626-31.
- Gilks, W.P., Allott, E.H., Donohoe, G., Cummings, E., Consortium, I.S., Gill, M., Corvin, A.P., Morris, D.W. and McGhee, K.A., 2010. Replicated genetic evidence supports a role for HOMER2 in schizophrenia. Neuroscience Letters, 468, 229-33.
- Wray, N.R., McGhee, K.A., McGhee, K.A. et al., 2010. Genome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learned. Molecular psychiatry.
- Christoforou, A., McGhee, K.A. et al., 2010. Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p. Molecular psychiatry.
- Walker, R.M., McGhee, K.A. et al., 2010. Association analysis of Neuregulin 1 candidate regions in schizophrenia and bipolar disorder. Neuroscience Letters.
- MacIntyre, D.J., McGhee, K.A., MacLean, A.W., Afzal, M., Briffa, K., Henry, B., Thomson, P.A., Muir, W.J. and Blackwood, D.H.R., 2010. Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population. Neuroscience Letters, 475, 169-173.
- Knight, H.M., McGhee, K. et al., 2009. A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression. Am J Hum Genet, 85 (6), 833-846.
- Raychaudhuri, S., McGhee, K.A. et al., 2009. Identifying relationships among genomic disease regions: Predicting genes at pathogenic SNP associations and rare deletions. PLoS Genetics, 5 (6).
- Purcell, S.M., Wray, N.R., Stone, J.L., Visscher, P.M., O'Donovan, M.C., Sullivan, P.F., Sklar, P., Consortium, I.S. and McGhee, K.A., 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature, 460, 748-52.
- Sullivan, P.F., McGhee, K.A. et al., 2009. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Molecular psychiatry, 14, 359-375.
- Pickard, B.S., McGhee, K.A. et al., 2008. A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder. Proceedings of the National Academy of Sciences of the United States of America, 105, 14940-14945.
- Kumar, R.A., McGhee, K.A. et al., 2008. Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 880-889.
- Sklar, P., McGhee, K.A. et al., 2008. Whole-genome association study of bipolar disorder. Molecular psychiatry, 13, 558-569.
- Stone, J.L., McGhee, K.A. et al., 2008. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature, 455, 237-241.
- Ferreira, M.A.R., McGhee, K.A. et al., 2008. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature genetics, 40, 1056-1058.
- Morris, D.W., McGhee, K.A. et al., 2008. Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility. Biological psychiatry, 63, 24-31.
- Donohoe, G., Morris, D.W., Robertson, I.H., McGhee, K.A., Murphy, K., Kenny, N., Clarke, S., Gill, M. and Corvin, A.P., 2007. DAOA ARG30LYS and verbal memory function in schizophrenia. Molecular psychiatry, 12, 795-796.
- Donohoe, G., Morris, D.W., Clarke, S., McGhee, K.A., Schwaiger, S., Nangle, J.-M., Garavan, H., Robertson, I.H., Gill, M. and Corvin, A., 2007. Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study. Neuropsychologia, 45, 454-458.
- Donohoe, G., Morris, D.W., Robertson, I.H., Clarke, S., McGhee, K.A., Schwaiger, S., Nangle, J.-M., Gill, M. and Corvin, A., 2007. Variance in facial recognition performance associated with BDNF in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B, 578-9.
- Corvin, A.P., McGhee, K.A. et al., 2007. Evidence for association and epistasis at the DAOA/G30 and D-amino acid oxidase loci in an Irish schizophrenia sample. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B, 949-53.
- Corvin, A., Donohoe, G., McGhee, K.A., Murphy, K., Kenny, N., Schwaiger, S., Nangle, J.M., Morris, D. and Gill, M., 2007. D-amino acid oxidase (DAO) genotype and mood symptomatology in schizophrenia. Neuroscience Letters, 426, 97-100.
- Nangle, J.-M., Clarke, S., Morris, D.W., Schwaiger, S., McGhee, K.A., Kenny, N., Murphy, K., Gill, M., Corvin, A. and Donohoe, G., 2006. Neurocognition and suicidal behaviour in an Irish population with major psychotic disorders. Schizophrenia Research, 85, 196-200.
- McGhee, K.A., McGhee, K.A. et al., 2005. Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs. Schizophrenia Research, 76, 231-238.
- Corvin, A., Morris, D.W., McGhee, K.A., Schwaiger, S., Scully, P., Quinn, J., Meagher, D., St Clair, D., Waddington, J.L. and Gill, M., 2004. Confirmation and refinement of an 'at-risk' haplotype for schizophrenia suggests the EST cluster, Hs.97362, as a potential susceptibility gene at the Neuregulin-1 locus. Molecular psychiatry, 9, 208-13.
- Morris, D.W., Rodgers, A., McGhee, K.A., Schwaiger, S., Scully, P., Quinn, J., Meagher, D., Waddington, J.L., Gill, M. and Corvin, A.P., 2004. Confirming RGS4 as a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 125B, 50-3.
- Morris, D.W., McGhee, K.A., Schwaiger, S., Scully, P., Quinn, J., Meagher, D., Waddington, J.L., Gill, M. and Corvin, A., 2003. No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study. Schizophrenia Research, 60, 167-172.
- Corvin, A.P., McGhee, K. et al., 2005. Evidence for association and interaction between G72 and DAAO markers in an Irish case-control schizophrenia sample. 25.
- McGhee, K.A., McGhee, K.A. et al., 2005. Association study of three oxidative stress genes putatively involved in the pathogenesis of schizophrenia in a large Irish case-control sample. 127-128.
- Donohoe, G., Morris, D., McGhee, K., Clarke, S., Nangle, J., Schwaiger, S., Garavan, H., Robertson, I.H., Gill, M. and Corvin, A., 2005. Evidence that dysbindin-1 is associated with poorer spatial working memory performance in schizophrenia. 120-121.
- Morris, D.W., McGhee, K.A. et al., 2005. Association analyses of the BLOC-1 genes suggest the involvement of BLOC-1 in schizophrenia etiology. 129.
- McGhee, K.A., McGhee, K.A. et al., 2004. Positive association of G72-G30 and DAAO with schizophrenia in an irish case-control sample. 138.
- McGhee, K.A., McGhee, K.A. et al., 2004. Association analysis in a large Irish case-control sample of HSPA8 and GSTM3, two genes putatively involved in schizophrenia. 130.
- Morris, D., McGhee, K. et al., 2004. An update on association studies of DTNBP1, NRG-1, RGS4 and MRDS1 in an extended Irish schizophrenia case-control sample. 143.
- Corvin, A., McGhee, K., Morris, D.W., Schwaiger, S., Quinn, J., Scully, P., Meagher, D., Waddington, J.L. and Gill, M., 2003. The apolipoprotein-1 (APOL) gene family and schizophrenia: An association study in an Irish case-control sample. 93.
- Morris, D., McGhee, K.A., Schwaiger, S., Scully, P., Quinn, J., Meagher, D., Waddington, J.L., Gill, M. and Corvin, A.P., 2003. The schizophrenia DTNBP1 gene: An investigation in an independent Irish association sample. 96.
- Morris, D.W., Corvin, A.P., McGhee, K.A., Schwaiger, S., Quinn, J., Scully, P., Morgan, M., Waddington, J.W. and Gill, M., 2002. Association analyses of dystrobrevin binding protein 1 gene variants in an Irish schizophrenia case-control sample. 861-862.
- McGhee, K.A., Corvin, A.P., Morris, D.W., Schwaiger, S., Quinn, J., Scully, P., Morgan, M., Waddington, J.W. and Gill, M., 2002. An association analysis of the apolipoprotein L gene family in an Irish schizophrenia sample. 858.
- Miss Emma Hill (Master by Research (MRes))
- Mr Kalon Grimes (Establishing a model for Schizophrenia: Investigating the molecular mechanisms using D. melanogaster.)
- Miss Rosa Spencer-Tansley (MRes student - Perceptions of Psychiatric Genetic Counselling)
- Miss Zara Ghodsi (A novel approach for the detection of point mutation)
- Miss Eva Reichardt (Oral drug testing)
Profile of Teaching UG
- Biological Research Skills - unit leader
- Advanced Skills for Biology - unit leader
- Practical Skills in Biology 1/3 of unit
- Biological Research Skills level 4
- Genetics - final year undergraduate
- Empowering service users: Assessing the potential benefits of Psychiatric Genetic Counselling (Higher Education Funding Council for England, 01 Aug 2016). Awarded
- Psychiatric Genetic Counselling for Healthcare Professionals (PGC4HP): First UK pilot study, regional knowledge exchange and global impact. (HEIF5+1, 01 Aug 2015). Completed
- Psychiatric Genetic Counselling: An international cultural shift (Fusion Investment Fund SMN strand, 01 Feb 2015). Completed
- Translating Schizophrenia and other psychiatric disorders: A three strand international approach (Fusion Investment Fund, Bournemouth University, 01 May 2014). Completed
- 2013 CANADA-UK COLLABORATION DEVELOPMENT AWARD (FOREIGN & COMMONWEALTH OFFICE, DEPARTMENT FOR BUSINESS, INNOVATION & SKILLS, 02 Nov 2013). Completed
- SFHEA in UK Professional Standards Framework (Higher Education Academy, UK, 2014)
- PhD in Psychiatric Genetics (2008)
- BSc (Hons) in Biomedical science (2001)
- American Society of Human Genetics, Member,
- European Society of Human Genetics, Member (2011-),
- International Society of Psychiatric Genetics, Member,
- Royal Society of Medicine, Member,
- The British Society for Genetic Medicine (formerly Human Genetics), Member,