Simon Dyall

Dr Simon Dyall

  • Principal Academic
  • Royal London House R312, Christchurch Road, Bournemouth, BH1 3LT
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Biography

Dr Simon Dyall read Biochemistry at the University of Sussex, followed by a PhD in Neuroscience in the Department of Neuroscience and Neurosurgery, Queen Mary University of London, investigating the neuroprotective roles of omega-3 fatty acids. Since this time he has lectured and conducted research at a number of different institutions.

In addition to being an elected member of the Board of Directors of the International Society for the Study of Fatty Acids and Lipids (ISSFAL) Simon is a member of numerous scientific societies and professional bodies and has been a reviewer for the American Institute of Biological Sciences (AIBS), BBSRC, MRC, US Army Medical Research and Material Command (USAMRMC) and other funders. He is on the Editorial Board of Lipids in Health and Disease and regularly reviews for many scientific journals. He is also Honorary Visiting Research Fellow in the Centre for Neuroscience and Trauma, Queen Mary University of London and also the Department of Life Sciences, University of Roehampton...

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Research

Simon’s Bioactive Lipids Research Group investigates the potential neuroprotective effects of lipid mediators, such as the omega-3 fatty acids and their metabolites across the lifespan and after neurotrauma.

The studies in development and ageing have looked at a variety of key indices including, the glutamatergic system, cannabinoid signalling, retinoid signalling, (neuro)inflammation, oxidative stress and neurogenesis. These studies have helped elucidate some specific mechanisms of action which may underlie their beneficial effects. The work on neurotrauma has investigated both spinal cord injury and peripheral nerve injury, and more recently traumatic brain injury. In the area of spinal cord injury, significant therapeutic effects have been found. These are very important, as there is considerable potential for translation to the clinic.

Some current and recent projects include:

• Investigating the cross-talk between omega-3 fatty acids and endocannabinoids in regulating neural stem cell fate (collaboration with Dr Francisco Molina-Holgado, University of Roehampton).

• Quantifying the essential fatty acid intake of extremely premature infants receiving standard care in the UK (collaboration with Dr Laura De Rooy, St George’s University Hospitals Trust).

• Investigation of neuroprotective preparations for use in neurotrauma (collaboration with Prof Adina Michael-Titus, Queen Mary University of London).

• Investigating the beneficial effects of docosahexaenoic acid and synergistic nutrients in mobility and cognition in the older adult (collaboration with Dr Leigh Gibson and Dr Siobhan Strike, University of Roehampton).

Journal Articles

  • De Rooy, L., Hamdallah, H. and Dyall, S.C., 2016. Extremely preterm infants receiving standard care receive very low levels of arachidonic and docosahexaenoic acids. Clinical Nutrition.
  • Wainwright, T., Branney, J., Dyall, S. and Middleton, R., 2016. What is the evidence for nutritional supplementation in a hip and knee replacement ERAS protocol? Clinical Nutrition ESPEN, 12.
  • Dyall, S.C., Mandhair, H.K., Fincham, R.E.A., Kerr, D.M., Roche, M. and Molina-Holgado, F., 2016. Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways. Neuropharmacology, 107, 378-395.
  • Strike, S.C., Carlisle, A., Gibson, E.L. and Dyall, S.C., 2016. A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility in Older Women: A Randomized, Double-blind, Placebo-controlled Pilot Study. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 71 (2), 236-242.
  • Dyall, S.C., Carlisle, A., Gibson, E.L. and Strike, S., 2015. The effects of an omega-3 fatty acid enriched supplement on physical performance in older women - a randomised double-blind placebo controlled study. Proceedings of the Nutrition Society, 74 (OCE2), E178.
  • Dyall, S.C., Carlisle, A., Gibson, E.L. and Strike, S., 2015. Blood levels of the omega-3 fatty acid docosahexaenoic acid are associated with gait and lower limb power in older females. Proceedings of the Nutrition Society, 74 (OCE2), E168.
  • Dyall, S., 2015. Long-chain omega-3 fatty acids and the brain: A review of the independent and shared effects of EPA, DPA and DHA. Frontiers in Aging Neuroscience, 7 (52), 1-15.
  • Yip, P.K., Dyall, S.C. et al., 2013. The Omega-3 Fatty Acid Eicosapentaenoic Acid Accelerates Disease Progression in a Model of Amyotrophic Lateral Sclerosis. PLoS ONE, 8 (4).
  • Lim, S.N., Gladman, S.J., Dyall, S.C., Patel, U., Virani, N., Kang, J.X., Priestley, J.V. and Michael-Titus, A.T., 2013. Transgenic mice with high endogenous omega-3 fatty acids are protected from spinal cord injury. Neurobiology of Disease, 51, 104-112.
  • Strike, S., Carlisle, A. and Dyall, S., 2012. PRELIMINARY INVESTIGATION OF JUMPING ABILITY OF OLDER ADULTS. JOURNAL OF AGING AND PHYSICAL ACTIVITY, 20, S269.
  • Carlisle, A., Strike, S. and Dyall, S., 2012. Preliminary investigation into gait characteristics and jump performance in older adults. JOURNAL OF AGING AND PHYSICAL ACTIVITY, 20, S248-S249.
  • Gladman, S.J., Huang, W., Lim, S.N., Dyall, S.C., Boddy, S., Kang, J.X., Knight, M.M., Priestley, J.V. and Michael-Titus, A.T., 2012. Improved outcome after peripheral nerve injury in mice with increased levels of endogenous Omega-3 polyunsaturated fatty acids. Journal of Neuroscience, 32 (2), 563-571.
  • Gladman, S., Lim, S.N., Dyall, S., Knight, M.M., Priestley, J.V. and Michael-Titus, A.T., 2011. Omega-3 fatty acids and acute neurological trauma: A perspective on clinical translation. OCL - Oleagineux Corps Gras Lipides, 18 (6), 317-323.
  • Dyall, S.C., 2011. The role of omega-3 fatty acids in adult hippocampal Neurogenesis. OCL - Oleagineux Corps Gras Lipides, 18 (5), 242-245.
  • Dyall, S.C., 2011. The Journées chevreul 2011 lipids and brain 2. Clinical Lipidology, 6 (3), 265-268.
  • Dyall, S., 2011. Methodological issues and inconsistencies in the field of omega-3 fatty acids research. Prostaglandins, Leukotrienes and Essential Fatty Acids, 85 (5), 281-285.
  • Dyall, S.C., Michael, G.J. and Michael-Titus, A.T., 2010. Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. Journal of Neuroscience Research, 88 (10), 2091-2102.
  • Robson, L.G., Dyall, S., Sidloff, D. and Michael-Titus, A.T., 2010. Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. Neurobiology of Aging, 31 (4), 678-687.
  • Dyall, S.C., 2010. Amyloid-beta peptide, oxidative stress and inflammation in Alzheimer’s disease: Potential neuroprotective effects of omega-3 polyunsaturated fatty acids. International Journal of Alzheimer's Disease Article, ID 274128.
  • Dyall, S.C. and Michael-Titus, A.T., 2008. Neurological benefits of omega-3 fatty acids. NeuroMolecular Medicine, 10 (4), 219-235.
  • Huang, W.L., King, V.R., Curran, O.E., Dyall, S.C., Ward, R.E., Lal, N., Priestley, J.V. and Michael-Titus, A.T., 2007. A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. Brain, 130 (11), 3004-3019.
  • Dyall, S.C., Michael, G.J., Whelpton, R., Scott, A.G. and Michael-Titus, A.T., 2007. Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. Neurobiology of Aging, 28 (3), 424-439.
  • Makwana, M., Raivich, G., Dyall, S. and Michael-Titus, A., 2007. Effect of docosahexaenoic acid in a mouse facial nerve injury model. OCL - Oleagineux Corps Gras Lipides, 14 (3-4), 233.
  • Dyall, S.C., Michael, G.J. and Michael-Titus, A.T., 2007. Omega-3 polyunsaturated fatty acids reverse age-related decreases in retinoic acid receptors, retinoid x receptors and peroxisome-proliferator-activated receptors in rat forebrain. OCL - Oleagineux Corps Gras Lipides, 14 (3-4), 232.
  • King, V.R., Huang, W.L., Dyall, S., Curran, O.E., Priestley, J.V. and Michael-Titus, A.T., 2006. Omega-3 Fatty Acids Improve Recovery, whereas Omega-6 Fatty Acids Worsen Outcome, after Spinal Cord Injury in the Adult Rat. The Journal of Neuroscience, 26 (17), 4672-4680.
  • Dyall, S., 2004. ChemOffice Ultra 2005. CHEMISTRY WORLD, 1 (10), 67-68.

Chapters

  • Dyall, S.C., 2014. The role of omega-3 fatty acids in hippocampal neurogenesis. In: Watson, R.R. and De Meester, F., eds. Omega-3 fatty acids in Brain and Neurological Health. Academic Press, 251-263.
  • Gibson, E.L., Green, M.W. and Dyall, S.C., 2012. Behavior: Effects of diet on behavior. In: Caballero, B., ed. Encyclopedia of Human Nutrition. Waltham, MA: Academic Press, 129-141.

Conferences

  • De Rooy, L., Dyall, S. and Hamdallah, H., 2016. Arachidonic and Docosahexaenoic acid intakes are low in extremely preterm infants receiving standard neonatal intensive care in the UK. 1498-1499.
  • Branney, J., Dyall, S., Wainwright and Middleton, R., 2016. A review of the literature related to the role of nutritional supplementation in an enhanced recovery pathway for hip and knee replacement. In: RCN Society of Orthopaedic and Trauma Nursing International Conference and Exhibition 8-9 September 2016 Cardiff.
  • Dyall, S.C., Mandhair, H., Fincham, R., Kerr, D., Roche, M. and Molina-Holgado, F., 2016. Eicosapentaenoic and docosahexaenoic acids increase levels of the endocannabinoid 2-arachidonoylglycerol in neural stem cells. In: 12th Congress of the International Society for the Study of Fatty Acids and Lipids 5-9 September 2016 South Africa.
  • Dyall, S.C., De Rooy, L. and Hamdallah, H., 2016. Blood AA and DHA levels correlate with markers of inflammation in extremely preterm infants. In: 12th Congress of the International Society for the Study of Fatty Acids and Lipids 5-9 September 2016 South Africa.
  • Dyall, S.C., De Rooy, L. and Hamdallah, H., 2016. Variability of breast milk AA and DHA content from mothers of extremely preterm infants. In: 12th Congress of the International Society for the Study of Fatty Acids and Lipids 5-9 September 2016 South Africa.
  • Dyall, S.C., De Rooy, L. and Hamdallah, H., 2016. Relationships between dietary intake and blood levels of omega-3 and omega-6 fatty acids in extremely preterm infants. In: 12th Congress of the International Society for the Study of Fatty Acids and Lipids 5-9 September 2016 South Africa.
  • Dyall, S.C., De Rooy, L. and Hamdallah, H., 2016. Extremely preterm infants receiving standard neonatal intensive care receive very low levels of AA and DHA. In: 12th Congress of the International Society for the Study of Fatty Acids and Lipids 5-9 September 2016 South Africa.
  • Wainwright, T., Branney, J., Dyall, S. and Middleton, R., 2016. What is the evidence for nutritional supplementation in a hip and knee replacement ERAS protocol. In: World Congress of Enhanced Recovery After Surgery 27-30 April 2016 Lisbon, Portugal.
  • Gibson, L., Strike, S., Carlisle, A. and Dyall, S.C., 2016. A high omega-3 fatty acid multinutrient supplement benefits cognition and mobility in older women. In: British Psychological Society Annual Conference 26-28 April 2016 Nottingham, UK.
  • Wainwright, T., Branney, J., Dyall, S. and Middleton, R., 2016. What is the evidence for nutritional supplementation in a hip and knee replacement ERAS protocol? England. e58.

PhD Students

  • Isabell Nessel (Investigating essential fatty acid intakes and requirements in the perinatal period; pregnant women, preterm and term infants)
  • Paul Fairburn (An investigation into the effects of omega-3 fatty acids on muscle and cognitive function in postmenopausal women)

Profile of Teaching PG

  • Dissertation Project
  • Nutrition in the Prevention and Management of Disease
  • Contemporary Nutrition
  • Advanced Research Methods
  • Nutrition and Brain Function Across the Lifespan

Profile of Teaching UG

  • Research Methods 1
  • Human Anatomy and Physiology

Grants

  • The effects of omega-3 fatty acids and associated nutrients and exercise in older adults (Sylvia Waddilove Foundation UK, 30 Sep 2016). Awarded
  • Present papers at ISSFAL Congress 2016 (Biochemical Society, 03 Sep 2016). Awarded
  • Investigating essential fatty acid intakes and requirements in the perinatal period; pregnant women, preterm and term infants (Fully funded BU PhD studentship, 25 Jan 2016). Awarded
  • The effects of omega-3 fatty acids and exercise on mobility and cognition in the older adult (Match-funded PhD studentship with Efamol Ltd, 01 Sep 2015). Awarded
  • Quantifying the essential fatty acid intake of extremely preterm infants (First Touch Neonatal NHS Charitable Fund, 01 Jan 2014). Awarded
  • Lipidomics profiling of patients with amyotrophic lateral sclerosis (Roehampton University Internal Award, 01 Jan 2012). Completed
  • The role of omega-3 fatty acids and endocannabinoid signaling in neural stem cells (The Dowager Countess Eleanor Peel Trust, 01 Jan 2011). In Progress
  • An investigation into the effects of omega-3 fatty acids on muscle and cognitive function in postmenopausal women (Efamol Ltd / Wassen Intl. Ltd, 01 Jan 2011). Completed
  • The effects of omega-3 fatty acids on static and dynamic balance in children (Efamol Ltd / Wassen Intl. Ltd, 01 Jan 2010). Awarded

External Responsibilities

Qualifications

  • PhD in Neuroscience (Queen Mary University of London, 2005)
  • 1st Class in Biochemistry (Sussex University, 2002)

Memberships

The data on this page was last updated at 04:02 on July 23, 2017.