Elpida Fragkouli

Dr Elpida Fragkouli

  • Senior Lecturer in Biomedical Science
  • CH
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Biography

I obtained a BSc in Molecular Biology from the University of Surrey, an MSc in Biochemistry (Genetic Manipulation and Molecular Biology) from the University of Sussex, an MSc in Prenatal Genetics and Fetal Medicine from University College London, followed by a PhD in human genetics. After completing my studies, I performed clinical diagnostics at the UCL Centre for Preimplantation Genetic Diagnosis (PGD) and carried out research into the cytogenetics of human oocytes. I later moved to the USA, taking a research position at Yale University Medical School. In 2007 I returned to the UK, and briefly worked as a researcher in the Nuffield Department of Women’s and Reproductive Health in the University of Oxford. I then joined Reprogenetics UK, a PGD laboratory that was based in Oxford, as a senior cytogeneticist. I worked in Reprogenetics UK for over 10 years. During my time at Reprogenetics UK I ended up overseeing and directing a large team of PGD specialist scientists and was involved in the organisation of a very successful clinical service for the PGD of chromosome and single gene disorders, as well as for numerical chromosome abnormalities...

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Journal Articles

  • Fragouli, E. and Mantzouratou, A., 2021. Endometrial receptivity: miRNAs signing in? Fertility and Sterility, 116 (1), 78-79.
  • Fragkouli, E., Cutts, G. and Babariya, D., 2020. Preimplantation genetic testing for aneuploidy: the conundrum with aneuploid embryo transfers. Fertility and Sterility, 114 (1), 65-66.
  • Tiegs, A.W., Tao, X., Landis, J., Zhan, Y., Franasiak, J.M., Seli, E., Wells, D., Fragkouli, E. and Scott, R.T., 2020. Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes. Reproductive Sciences, 27 (6), 1350-1356.
  • Fragkouli, E. and Garrido, N., 2020. Human female meiosis checkpoints: how much DNA damage is allowed? Fertility and Sterility, 113 (5), 943-944.
  • Munne, S., Spinella, F., Grifo, J., Zhang, J., Beltran, M.P., Fragkouli, E. and Fiorentino, F., 2020. Clinical outcomes after the transfer of blastocysts characterized as mosaic by high resolution Next Generation Sequencing- further insights. European Journal of Medical Genetics, 63 (2), 103741.
  • Cram, D.S., Fragkouli, E. et al., 2019. PGDIS Position Statement on the Transfer of Mosaic Embryos 2019. Reproductive Biomedicine Online, 39 (Supplement 1), e1-e4.
  • Fragouli, E., Munne, S. and Wells, D., 2019. The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies. Hum Reprod Update, 25 (1), 15-33.
  • Fragouli, E. and Wells, D., 2018. Pores for thought: preimplantation genetic testing using a nanopore-based DNA sequencer. Fertil Steril, 110 (5), 853-855.
  • Fragouli, E. and Wells, D., 2018. Current status and future prospects of noninvasive preimplantation genetic testing for aneuploidy. Fertil Steril, 110 (3), 408-409.
  • Fragouli, E., 2018. Next generation sequencing for preimplantation genetic testing for aneuploidy: friend or foe? Fertil Steril, 109 (4), 606-607.
  • Babariya, D., Fragouli, E., Alfarawati, S., Spath, K. and Wells, D., 2017. The incidence and origin of segmental aneuploidy in human oocytes and preimplantation embryos. Hum Reprod, 32 (12), 2549-2560.
  • Fragouli, E., McCaffrey, C., Ravichandran, K., Spath, K., Grifo, J.A., Munné, S. and Wells, D., 2017. Clinical implications of mitochondrial DNA quantification on pregnancy outcomes: a blinded prospective non-selection study. Hum Reprod, 32 (11), 2340-2347.
  • Wells, D., Ravichandran, K., McCaffrey, C., Grifo, J., Morales, A., Perloe, M., Munne, S. and Fragkouli, E., 2017. Mitochondrial DNA Quantification- the devil in the detail. Human Reproduction, 32 (10), 2150-2151.
  • Fragouli, E., Alfarawati, S., Spath, K., Babariya, D., Tarozzi, N., Borini, A. and Wells, D., 2017. Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts. Hum Genet, 136 (7), 805-819.
  • Munné, S. et al., 2017. Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing. Fertil Steril, 108 (1), 62-71.e8.
  • Ravichandran, K., McCaffrey, C., Grifo, J., Morales, A., Perloe, M., Munne, S., Wells, D. and Fragouli, E., 2017. Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers. Hum Reprod, 32 (6), 1282-1292.
  • Hyslop, L.A., Fragkouli, E. et al., 2016. Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease. Nature, 534 (7606), 383-386.
  • Enciso, M., Sarasa, J., Xanthopoulou, L., Bristow, S., Bowles, M., Fragouli, E., Delhanty, J. and Wells, D., 2016. Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy. Hum Genet, 135 (5), 555-568.
  • Fragouli, E. and Wells, D., 2015. Mitochondrial DNA Assessment to Determine Oocyte and Embryo Viability. Semin Reprod Med, 33 (6), 401-409.
  • Fragouli, E., Spath, K., Alfarawati, S., Kaper, F., Craig, A., Michel, C.-E., Kokocinski, F., Cohen, J., Munne, S. and Wells, D., 2015. Altered levels of mitochondrial DNA are associated with female age, aneuploidy, and provide an independent measure of embryonic implantation potential. PLoS Genet, 11 (6), e1005241.
  • Konstantinidis, M., Alfarawati, S., Hurd, D., Paolucci, M., Shovelton, J., Fragouli, E. and Wells, D., 2014. Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform. Fertil Steril, 102 (5), 1385-1392.
  • Wells, D., Kaur, K., Grifo, J., Glassner, M., Taylor, J.C., Fragouli, E. and Munne, S., 2014. Clinical utilisation of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation. J Med Genet, 51 (8), 553-562.
  • Fragouli, E., Alfarawati, S., Spath, K. and Wells, D., 2014. Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos. Mol Hum Reprod, 20 (2), 117-126.
  • Fragouli, E., Lalioti, M.D. and Wells, D., 2014. The transcriptome of follicular cells: biological insights and clinical implications for the treatment of infertility. Hum Reprod Update, 20 (1), 1-11.
  • Fragouli, E., Alfarawati, S., Spath, K., Jaroudi, S., Sarasa, J., Enciso, M. and Wells, D., 2013. The origin and impact of embryonic aneuploidy. Hum Genet, 132 (9), 1001-1013.
  • Fragouli, E. and Wells, D., 2013. Questions about the accuracy of polar body analysis for preimplantation genetic screening. Hum Reprod, 28 (6), 1731-1732.
  • Fragouli, E. and Wells, D., 2012. Aneuploidy screening for embryo selection. Semin Reprod Med, 30 (4), 289-301.
  • Fragouli, E., Wells, D., Iager, A.E., Kayisli, U.A. and Patrizio, P., 2012. Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy. Hum Reprod, 27 (8), 2559-2568.
  • Munné, S., Held, K.R., Magli, C.M., Ata, B., Wells, D., Fragouli, E., Baukloh, V., Fischer, R. and Gianaroli, L., 2012. Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes. Fertil Steril, 97 (4), 935-942.
  • Alfarawati, S., Fragouli, E., Colls, P. and Wells, D., 2012. Embryos of robertsonian translocation carriers exhibit a mitotic interchromosomal effect that enhances genetic instability during early development. PLoS Genet, 8 (10), e1003025.
  • Fragouli, E. and Wells, D., 2012. Transcriptomic analysis of follicular cells provides information on the chromosomal status and competence of unfertilized oocytes. Expert Rev Mol Diagn, 12 (1), 1-4.
  • Huang, Z., Fragouli, E. and Wells, D., 2012. Biomolecules of human female fertility--potential therapeutic targets for pharmaceutical design. Curr Pharm Des, 18 (3), 310-324.
  • Alfarawati, S., Fragouli, E., Colls, P. and Wells, D., 2011. First births after preimplantation genetic diagnosis of structural chromosome abnormalities using comparative genomic hybridization and microarray analysis. Hum Reprod, 26 (6), 1560-1574.
  • Fragouli, E., Alfarawati, S., Goodall, N.-N., Sánchez-García, J.F., Colls, P. and Wells, D., 2011. The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy. Mol Hum Reprod, 17 (5), 286-295.
  • Wells, D., Alfarawati, S. and Fragouli, E., 2011. A skewed sex ratio following blastocyst culture is a consequence of embryo grading systems that prioritise male embryos for transfer. BJOG, 118 (3), 381.
  • Alfarawati, S., Fragouli, E., Colls, P., Stevens, J., Gutiérrez-Mateo, C., Schoolcraft, W.B., Katz-Jaffe, M.G. and Wells, D., 2011. The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender. Fertil Steril, 95 (2), 520-524.
  • Fragkouli, E., Alfarawati, S., Daphnis, D.D., Goodall, N.N., Mania, A., Griffiths, T., Gordon, A. and Wells, D., 2011. Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation. Human Reproduction, 26 (2), 480-490.
  • Fragouli, E., Wells, D. and Delhanty, J.D.A., 2011. Chromosome abnormalities in the human oocyte. Cytogenet Genome Res, 133 (2-4), 107-118.
  • Fragouli, E. and Wells, D., 2011. Aneuploidy in the human blastocyst. Cytogenet Genome Res, 133 (2-4), 149-159.
  • Schoolcraft, W.B., Fragouli, E., Stevens, J., Munne, S., Katz-Jaffe, M.G. and Wells, D., 2010. Clinical application of comprehensive chromosomal screening at the blastocyst stage. Fertil Steril, 94 (5), 1700-1706.
  • Fragouli, E., Bianchi, V., Patrizio, P., Obradors, A., Huang, Z., Borini, A., Delhanty, J.D.A. and Wells, D., 2010. Transcriptomic profiling of human oocytes: association of meiotic aneuploidy and altered oocyte gene expression. Mol Hum Reprod, 16 (8), 570-582.
  • Fragouli, E. et al., 2010. Comprehensive chromosome screening of polar bodies and blastocysts from couples experiencing repeated implantation failure. Fertil Steril, 94 (3), 875-887.
  • Munné, S., Fragouli, E., Colls, P., Katz-Jaffe, M., Schoolcraft, W. and Wells, D., 2010. Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test. Reprod Biomed Online, 20 (1), 92-97.
  • Fragouli, E., Escalona, A., Gutiérrez-Mateo, C., Tormasi, S., Alfarawati, S., Sepulveda, S., Noriega, L., Garcia, J., Wells, D. and Munné, S., 2009. Comparative genomic hybridization of oocytes and first polar bodies from young donors. Reprod Biomed Online, 19 (2), 228-237.
  • Wells, D., Alfarawati, S. and Fragouli, E., 2008. Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH. Mol Hum Reprod, 14 (12), 703-710.
  • Fragouli, E., Lenzi, M., Ross, R., Katz-Jaffe, M., Schoolcraft, W.B. and Wells, D., 2008. Comprehensive molecular cytogenetic analysis of the human blastocyst stage. Hum Reprod, 23 (11), 2596-2608.
  • Daphnis, D.D., Fragouli, E., Economou, K., Jerkovic, S., Craft, I.L., Delhanty, J.D.A. and Harper, J.C., 2008. Analysis of the evolution of chromosome abnormalities in human embryos from Day 3 to 5 using CGH and FISH. Mol Hum Reprod, 14 (2), 117-125.
  • Patrizio, P., Fragouli, E., Bianchi, V., Borini, A. and Wells, D., 2007. Molecular methods for selection of the ideal oocyte. Reprod Biomed Online, 15 (3), 346-353.
  • Fragouli, E., Delhanty, J.D.A. and Wells, D., 2007. Single cell diagnosis using comparative genomic hybridization after preliminary DNA amplification still needs more tweaking: too many miscalls. Fertil Steril, 88 (1), 247-248.
  • Fragouli, E., 2007. Preimplantation genetic diagnosis: present and future. J Assist Reprod Genet, 24 (6), 201-207.
  • Mantzouratou, A. et al., 2007. Variable aneuploidy mechanisms in embryos from couples with poor reproductive histories undergoing preimplantation genetic screening. Human Reproduction, 22 (7), 1844-1853.
  • Fragouli, E., Wells, D., Thornhill, A., Serhal, P., Faed, M.J.W., Harper, J.C. and Delhanty, J.D.A., 2006. Comparative genomic hybridization analysis of human oocytes and polar bodies. Hum Reprod, 21 (9), 2319-2328.
  • Fragouli, E., Wells, D., Doshi, A., Gotts, S., Harper, J.C. and Delhanty, J.D.A., 2006. Complete cytogenetic investigation of oocytes from a young cancer patient with the use of comparative genomic hybridisation reveals meiotic errors. Prenat Diagn, 26 (1), 71-76.
  • Fragouli, E., Wells, D., Whalley, K.M., Mills, J.A., Faed, M.J.W. and Delhanty, J.D.A., 2006. Increased susceptibility to maternal aneuploidy demonstrated by comparative genomic hybridization analysis of human MII oocytes and first polar bodies. Cytogenet Genome Res, 114 (1), 30-38.
  • Simopoulou, M., Mantzouratou, A. et al., 2003. Preimplantation genetic diagnosis of chromosome abnormalities: Implications from the outcome for couples with chromosomal rearrangements. Prenatal Diagnosis, 23 (8), 652-662.
  • Cupisti, S., Conn, C.M., Fragouli, E., Whalley, K., Mills, J.A., Faed, M.J.W. and Delhanty, J.D.A., 2003. Sequential FISH analysis of oocytes and polar bodies reveals aneuploidy mechanisms. Prenat Diagn, 23 (8), 663-668.

Chapters

  • Mania, A. and Fragkouli, E., 2022. Preimplantation Genetic Testing. Clinical Protocols in Reproductive Medicine. Cambridge University Press.
  • Fragkouli, E., Alfarawati, S. and Mantzouratou, A., 2021. Individualised genetic testing: who benefits? Individualised IVF. Cambridge University Press.
  • Fragkouli, E. and Wells, D., 2021. Genomics for embryo selection: an Introduction. Manual of Embryo Selection in Human Assisted Reproduction. Cambridge University Press.
  • Fragkouli, E., 2020. Mitochondrial Genetics. Human Reproductive Genetics. Elsevier.
  • Fragkouli, E. and Wells, D., 2016. Transcriptomic analysis of cumulus and granulosa cells as a marker of embryo viability. In: Gardner, D., Sakkas, D. and Seli, E., eds. Gamete and embryo assessment in assisted reproduction: emerging technologies. Springer Scientific.
  • Wells, D. and Fragkouli, E., 2013. Preimplantation genetic diagnosis. In: Coward, K., ed. The Textbook of Clinical Embryology. Cambridge University Press.
  • Wells, D. and Fragkouli, E., 2012. Preimplantation genetic diagnosis for infertility. In: Gardner, D., Weissman, A., Howles, C. and Shoham, Z., eds. Textbook of Assisted Reproductive technologies. CRC Press.

Conferences

  • Tiegs, A.W., Tao, X., Landis, J., Rajchel, J., Bedard, J.L., Seli, E., Wells, D., Fragouli, E. and Scott, R., 2018. EVALUATION OF SPERM MITOCHONDRIAL DNA COPY NUMBER AS A PREDICTOR OF IN VITRO FERTILIZATION/INTRACYTOPLASMIC SPERM INJECTION (IVF/ICSI) CYCLE OUTCOMES IN A LARGE INFERTILE POPULATION. FERTILITY AND STERILITY, 110 (4), E75-E76.
  • Wells, D., Babariya, D., Alfarawati, S., Spath, K., Kubikova, N., Munne, S. and Fragouli, E., 2017. Frequency and clinical relevance of mosaic segmental aneuploidy in blastocyst stage human embryos. HUMAN REPRODUCTION, 32, 50-51.
  • Munne, S. et al., 2017. Clinical results following the transfer of mosaic blastocystsimpact of different aneuploidy types to ongoing implantation rates. HUMAN REPRODUCTION, 32, 133-134.
  • Cutts, G., Simpkins, M., Spath, K., Kubikova, N., Alfarawati, S., Wells, D. and Fragouli, E., 2017. Patient characteristics influence the outcome of embryo aneuploidy testing cycles. HUMAN REPRODUCTION, 32, 425-426.
  • Kubikova, N., Spath, K., Babariya, D., Simpkins, M., Cutts, G., Alfarawati, S., Fragouli, E. and Wells, D., 2017. 'Batching' of multiple IVF cycles combined with preimplantation genetic testing for aneuploidy: how does the number of cycles undertaken affect outcomes? HUMAN REPRODUCTION, 32, 430-431.
  • Simpkins, M., Alfarawati, S., Cutts, G., Spath, K., Kubikova, N., Wells, D. and Fragouli, E., 2017. The relationship between blastocyst morphology, euploidy, aneuploidy and mosaicism. HUMAN REPRODUCTION, 32, 50.
  • Fragouli, E., Alfarawati, S., Simpkins, M., Cutts, G., Spath, K., Babariya, D., Kubikova, N., Rubistello, L., Munne, S. and Wells, D., 2017. Factors affecting embryonic mosaicism. HUMAN REPRODUCTION, 32, 49-50.
  • Spath, K. et al., 2017. Development, validation and first clinical application of a novel ultra-rapid comprehensive chromosome screening technique utilising an array based nano scale quantitative DNA amplification technology. HUMAN REPRODUCTION, 32, 16.
  • Sawarkar, S.S., Large, M., Fragouli, E., Wells, D., Escudero, T., Ribustello, L., Blazek, J. and Munne, S., 2017. PGS ANALYSIS OF OVER 100,000 BLASTOCYSTS USING HIGH RESOLUTION NEXT GENERATION SEQUENCING. FERTILITY AND STERILITY, 108 (3), E19-E20.
  • Ravichandran, K., Mccaffrey, C., Grifo, J., Morales, A., Perloe, M., Munne, S., Wells, D. and Fragouli, E., 2016. Clinical outcome of SET transfer of euploid embryos by Next Generation Sequencing with and without MitoGrade (mitochondrial DNA selection). HUMAN REPRODUCTION, 31, 403.
  • Ravichandran, K., McCaffrey, C., Grifo, J., Perloe, M., Rosen, A.M., Singer, T., Munne, S., Wells, D. and Fragouli, E., 2016. TRANSFER OF BLASTOCYSTS WITH LOWER MITOCHONDRIAL DNA (MTDNA) QUANTITIES IMPROVES IVF OUTCOMES. FERTILITY AND STERILITY, 106 (3), E23.
  • Fragouli, E., Ravichandran, K., Munne, S., Grifo, J., McCaffrey, C. and Wells, D., 2016. CLINICAL APPLICATION OF MITOCHONDRIAL DNA QUANTIFICATION FOR EMBRYO VIABILITY ASSESSMENT: A BLINDED PROSPECTIVE NON-SELECTION STUDY. FERTILITY AND STERILITY, 106 (3), E69.
  • Rosenfeld, J., Kung, A., Ravichandran, K., Yeboah, E., Goodall, N., Barbieri, E., Coates, A., Mounts, E., Fragouli, E. and Munne, S., 2016. QUANTITATIVE RELATIONSHIP BETWEEN MITOCHONDRIAL DNA (MTDNA) AMOUNTS AND IMPLANTATION CAN HELP IMPROVE PREGNANCY OUTCOMES. FERTILITY AND STERILITY, 106 (3), E68.
  • Tormasi, S., Capaldi, R., Gouw, F., Munne, S., Wells, D. and Fragouli, E., 2016. THE USE OF NEXT GENERATION SEQUENCING TO DETERMINE THE DEVELOPMENTAL POTENTIAL OF MOSAIC BLASTOCYSTS. FERTILITY AND STERILITY, 105 (2), E41.
  • Babariya, D., Fragouli, E., Alfarawati, S., Spaeth, K., Raberi, A., Taylor, S., Kubikova, N. and Wells, D., 2016. The clinical significance of segmental aneuploidy in human oocytes and preimplantation embryos. HUMAN REPRODUCTION, 31, 13-14.
  • Taylor, S.M., Knebel, S., Alfarawati, S., Fragouli, E., Wells, D. and Held, K.R., 2016. PREIMPLANTATION GENETIC DIAGNOSIS OF RECIPROCAL TRANSLOCATIONS USING POLAR BODIES - FIRST VALIDATION USING A NEXT-GENERATION SEQUENCING PLATFORM. FERTILITY AND STERILITY, 106 (3), E158.
  • Wells, D., Alfarawati, S., Taylor, S., Kubikova, N., Spath, K., Turner, K., Hickman, C. and Fragouli, E., 2016. Evidence that differences between embryology laboratories can influence the rate of mitotic errors, leading to increased chromosomal mosaicism, with significant implications for IVF success rates. HUMAN REPRODUCTION, 31, 25-26.
  • Taylor, S., Alfarawati, S., Knebel, S., Held, K., Wells, D. and Fragouli, E., 2016. First validation of a next-generation sequencing platform for preimplantation genetic diagnosis of reciprocal translocations using polar bodies. HUMAN REPRODUCTION, 31, 409-410.
  • Babariya, D., Fragouli, E., Alfarawati, S., Spath, K., Raberi, A., Taylor, S., Kubikova, N. and Wells, D., 2016. PREVALENCE AND CLINICAL SIGNIFICANCE OF SEGMENTAL ANEUPLOIDY IN HUMAN OOCYTES AND PREIMPLANTATION EMBRYOS. FERTILITY AND STERILITY, 106 (3), E18.
  • Tarozzi, N., Nadalini, M., Di Santo, M., Lagalla, C., Distratis, V., Pennetta, F., Fragouli, E., Wells, D. and Borini, A., 2016. Mitochondrial DNA content as a measure of implantation potential in human euploid blastocysts: correlation with embryo quality and female age. HUMAN REPRODUCTION, 31, 205.
  • Pomante, A., Magli, M.C., Wells, D., Alfarawati, S., Fragouli, E., Bianchi, V., Ferraretti, A.P. and Gianaroli, L., 2016. Analysis of DNA from blastocoelic fluid (BF) and corresponding trophectoderm (TE) cells by array-CGH and NGS. HUMAN REPRODUCTION, 31, 407-408.
  • Fragouli, E., Cohen, J., Munne, S., Grifo, J., McCaffrey, C. and Wells, D., 2015. THE BIOLOGICAL AND CLINICAL IMPACT OF MITOCHONDRIAL GENOME VARIATION IN HUMAN EMBRYOS. FERTILITY AND STERILITY, 104 (3), E36.
  • Spath, K., Alfarawati, S., Babariya, D., Raberi, A., Wells, D. and Fragouli, E., 2015. Do multiple IVF cycles increase the chance of having a euploid embryo in females of advanced age? HUMAN REPRODUCTION, 30, 81-82.
  • Alfarawati, S., Babariya, D., Spath, K., Wells, D. and Fragouli, E., 2015. Do culture conditions, patient factor or female age affect incidence of segmental chromosome errors in preimplantation embryos? HUMAN REPRODUCTION, 30, 52-53.
  • Jaroudi, S., Cariati, F., Konstantinidis, M., Fragouli, E. and Wells, D., 2015. Telomere length: correlation with aneuploidy risk and implantation potential of human oocytes and cleavage stage embryos. HUMAN REPRODUCTION, 30, 393.
  • Fragouli, E., Alfarawati, S., Spath, K., Tarozzi, N., Borini, A. and Wells, D., 2015. THE DEVELOPMENTAL POTENTIAL OF MOSAIC EMBRYOS. FERTILITY AND STERILITY, 104 (3), E96.
  • Fragouli, E., Alfarawati, S., Spath, K., Tarozzi, N., Borini, A. and Wells, D., 2015. An investigation into the developmental potential of mosaic embryos. HUMAN REPRODUCTION, 30, 2.
  • Fragouli, E., Alfarawati, S., Spath, K., Colls, P., Cohen, J., Munne, S. and Wells, D., 2014. Altered levels of mitochondrial DNA are associated with female age, aneuploidy, and reveal the implantation potential of chromosomally normal embryos. HUMAN REPRODUCTION, 29, 43.
  • Alfarawati, S., Fragouli, E., Spath, K., Colls, P. and Wells, D., 2014. A detailed analysis of embryos from translocation carriers: sex specific differences in segregation patterns and the presence of an interchromosomal effect. CHROMOSOME RESEARCH, 22 (4), 597-598.
  • Fragouli, E., 2014. Alternative molecular approaches for aneuploidy detection and IVF outcome prediction. CHROMOSOME RESEARCH, 22 (4), 586-587.
  • Kung, A., Wells, D., Munne, S., Kaur, K., Taylor, J., Fragouli, E., Colls, P. and Ribustello, L., 2014. Comparison of next generation sequencing (NGS) and aCGH for PGS. HUMAN REPRODUCTION, 29, 17.
  • Babariya, D., Alfarawaty, S., Spath, K., Fragouli, E. and Wells, D., 2014. Incidence of segmental aneuploidy in oocytes and pre implantation embryos. CHROMOSOME RESEARCH, 22 (4), 598-599.
  • Fragouli, E., Spath, K., Alfarawati, S. and Wells, D., 2013. QUANTIFICATION OF MITOCHONDRIAL DNA PREDICTS THE IMPLANTATION POTENTIAL OF CHROMOSOMALLY NORMAL EMBRYOS. FERTILITY AND STERILITY, 100 (3), S1.
  • Alfarawati, S., Spath, K., Colls, P., Wells, D. and Fragouli, E., 2013. Analysis of gametes and embryos from translocation carriers reveals sex-specific differences in chromosome segregation patterns and the existence of an interchromosomal effect. HUMAN REPRODUCTION, 28, 50-51.
  • Jaroudi, S., Konstantinidis, M., Alfarawati, S., Fragouli, E. and Wells, D., 2013. Assessment of telomere DNA length in human oocytes and cleavage stage embryos: impact on aneuploidy risk and implantation potential. HUMAN REPRODUCTION, 28, 41.
  • Wells, D., Kaur, K., Glassner, M., Grifo, J., Fragouli, E. and Munne, S., 2013. WHOLE-GENOME SEQUENCING TECHNOLOGY FOR THE ASSESSMENT OF EMBRYO GENETICS AND VIABILITY. FERTILITY AND STERILITY, 100 (3), S132-S133.
  • Spath, K., Fragouli, E., Konstantinidis, M., Poli, M. and Wells, D., 2013. Development and validation of rapid and cost-effective blastocyst comprehensive chromosome analysis methods utilising quantitative real-time PCR and microbead-based technologies. HUMAN REPRODUCTION, 28, 27.
  • Jaroudi, S., Konstantinidis, M., Alfarawati, S., Fragouli, E. and Wells, D., 2013. INVESTIGATION OF TELOMERE LENGTH AS AN INDICATOROF ANEUPLOIDY RISK AND IMPLANTATION POTENTIAL IN HUMAN OOCYTES AND CLEAVAGE STAGE EMBRYOS. FERTILITY AND STERILITY, 100 (3), S68-S69.
  • Fragouli, E., Alfarawati, S., Konstantinidis, M., Jaroudi, S. and Wells, D., 2012. Chromosome abnormalities in oocytes and embryos: the origin and impact of aneuploidy. HUMAN REPRODUCTION, 27.
  • Wells, D., Alfarawati, S., Konstantinidis, M., Jaroudi, S. and Fragouli, E., 2012. Characterisation of mechanisms causing oocyte aneuploidy reveals a flaw in embryo selection strategies based upon polar body chromosome screening. HUMAN REPRODUCTION, 27.
  • Alfarawati, S., Poli, M., Wells, D. and Fragouli, E., 2012. How does aneuploidy affect embryo morphology and development from the cleavage to the blastocyst stage. HUMAN REPRODUCTION, 27.
  • Jaroudi, S., Alfarawati, S., Poli, M., Wells, D. and Fragouli, E., 2012. THE EFFECT OF ANEUPLOIDY ON EMBRYO MORPHOLOGY AND PREIMPLANTATION DEVELOPMENT FROM THE CLEAVAGE TO THE BLASTOCYST STAGE. FERTILITY AND STERILITY, 98 (3), S164.
  • Alfarawati, S., Fragouli, E., Konstantinidis, M. and Wells, D., 2011. ARE PATIENTS UNDERGOING PGD FOR CHROMOSOME REARRANGEMENTS AT INCREASED RISK OF ANEUPLOIDY AFFECTING CHROMOSOMES UNRELATED TO THEIR REARRANGEMENT (INTERCHROMOSOMAL EFFECT)? FERTILITY AND STERILITY, 96 (3), S26.
  • Wells, D., Konstantinidis, M., Alfarawati, S., Hurd, D. and Fragouli, E., 2011. A NOVEL TOOL ALLOWS SIMULTANEOUS GENOMIC AND CYTOGENETIC ASSESSMENT OF OOCYTES AND EMBRYOS AND YIELDS UNIQUE DATA OF SCIENTIFIC AND CLINICAL IMPORTANCE. FERTILITY AND STERILITY, 96 (3), S18.
  • Fragouli, E., Huang, Z., Bianchi, V., Borini, A., Kayisli, U., Patrizio, P. and Wells, D., 2011. Follicle-specific predisposition to aneuploidy as revealed by transcriptomic analysis of cumulus cells. HUMAN REPRODUCTION, 26, I87.
  • Fragouli, E., Alfarawati, S., Konstantinidis, M., Jaroudi, S. and Wells, D., 2011. THE PROGRESS OF CHROMOSOME ABNORMALITIES FROM MEIOSIS TO THE BLASTOCYST STAGE. FERTILITY AND STERILITY, 96 (3), S62-S63.
  • Wells, D., Fragouli, E., Colls, P., Alfarawati, S. and Munne, S., 2011. Segmental chromosome imbalance in human oocytes and preimplantation embryos: incidence, origin and clinical relevance. HUMAN REPRODUCTION, 26, I102.
  • Fragouli, E., Huang, Z., Kayisli, U.A., Patrizio, P. and Wells, D., 2011. TRANCRIPTOMIC PROFILING OF CUMULUS CELLS FROM NORMAL AND ANEUPLOID OOCYTES: TOWARDS A NON-INVASIVE DIAGNOSIS OF MEIOTIC ANEUPLOIDY. FERTILITY AND STERILITY, 96 (3), S18.
  • Harton, G.L., Al-Farawaty, S., Goodall, N.-N., Tormasi, S., Wells, D. and Fragouli, E., 2010. THE TYPES OF CHROMOSOME ABNORMALITY IN BLASTOCYSTS GENERATED BY INFERTILE PATIENTS. FERTILITY AND STERILITY, 94 (4), S9-S10.
  • Alfarawati, S., Goodall, N., Gordon, T., Gunner, J., Daphnis, D., Wells, D. and Fragouli, E., 2010. Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation. HUMAN REPRODUCTION, 25, I41-I42.
  • Mania, A., Mantzouratou, A., Fragouli, E., Xanthopoulou, L., Tashkandi, S., Serhal, P., Harper, J. and Delhanty, J.D.A., 2007. Cytogenetic analysis of embryos from couples carrying balanced chromosomal translocations undergoing preimplantation genetic diagnosis. HUMAN REPRODUCTION, 22, I92-I93.
  • Mantzouratou, A. et al., 2007. Evidence of different mechanisms of aneuploidy in embryos from couples with distinct indications for preimplantation genetic screening. HUMAN REPRODUCTION, 22, I210.
  • Delhanty, J.D.A., Fragouli, E., Mantzouratou, A., Wells, D., Serhal, P. and Faed, M.J.W., 2007. Comprehensive analysis of human oocytes and 1st polar bodies by comparative genomic hybridisation (CGH). CHROMOSOME RESEARCH, 15, 146.
  • Fragouli, E., Bianchi, V., Delhanty, J., Patrizio, P. and Wells, D., 2007. Gene expression analysis of human oocytes: Towards a non-invasive diagnosis of meiotic aneuploidy. HUMAN REPRODUCTION, 22, I32.
  • Delhanty, J.D.A., Wells, D., Fragouli, E. and Faed, M.J.W., 2006. Aneuploidy detection by comparative genomic hybridisation analysis of oocytes and first polar bodies. JOURNAL OF MEDICAL GENETICS, 43, S33.
  • Fragouli, E., Wells, D., Thornhill, A., Faed, M., Harper, J. and Delhanty, J., 2006. Complete molecular cytogenetic analysis of human oocytes and polar bodies. FERTILITY AND STERILITY, 86, S85.
  • Wells, D., Fragouli, E., Bianchi, V., Obradors, A., Delhanty, J. and Patrizio, P., 2006. Comprehensive characterization of gene expression in human oocytes and identification of perturbations associated with meiotic aneuploidy, maturation and infertile pathology. FERTILITY AND STERILITY, 86, S40-S41.
  • Fragouli, E., Conn, C.M., Cupisti, S., Wells, D., Whaley, K., Mills, J.A., Faed, M.J.W. and Delhanty, J.D.A., 2003. Molecular cytogenetic investigations of aneuploidy mechanisms in oogenesis. HUMAN REPRODUCTION, 18, 185.
  • Fragouli, E., Conn, C.M., Cupisti, S., Whaley, K., Mills, J.A., Faed, M.J.W. and Delhanty, J.D.A., 2003. Mechanisms of maternal aneuploidy: FISH analysis of human oocytes and polar bodies. GENETICS RESEARCH, 81 (3), 230.

Profile of Teaching UG

  • Pathophysiology (deputy unit leader) Level 6
  • Biochemistry Level 5
  • Advanced Topics in Genetics Level 6
  • Biomedical Research Skills Level 4
  • Advanced Biomedical Research Skills Level 5
  • Introduction to Molecular Genetics Level 4
  • Foundation year project