Comparison of methods for the analysis of tricyclic antidepressants in small whole blood samples
Authors: Hughes, R.J. and Osselton, M.D.
Journal: Journal of Analytical Toxicology
Volume: 13
Issue: 2
Pages: 77-83
eISSN: 1945-2403
ISSN: 0146-4760
DOI: 10.1093/jat/13.2.77
Abstract:A variety of liquid-liquid and solid-phase extraction techniques have been compared for the extraction of tricyclic antidepressant drugs from small whole blood samples. Each of the procedures was evaluated with respect to extract cleanliness, extraction efficiency, and reproducibility. The three most efficient methods were compared on a variety of authentic whole blood case samples containing drugs at therapeutic and toxic levels. The results of the study indicated that a liquid-liquid extraction procedure involving the extraction of drugs by ether was the most suitable to use on poor quality forensic samples. © 1989, Oxford University Press. All rights reserved.
Source: Scopus
Comparison of methods for the analysis of tricyclic antidepressants in small whole blood samples.
Authors: Hughes, R.J. and Osselton, M.D.
Journal: J Anal Toxicol
Volume: 13
Issue: 2
Pages: 77-83
ISSN: 0146-4760
DOI: 10.1093/jat/13.2.77
Abstract:A variety of liquid-liquid and solid-phase extraction techniques have been compared for the extraction of tricyclic antidepressant drugs from small whole blood samples. Each of the procedures was evaluated with respect to extract cleanliness, extraction efficiency, and reproducibility. The three most efficient methods were compared on a variety of authentic whole blood case samples containing drugs at therapeutic and toxic levels. The results of the study indicated that a liquid-liquid extraction procedure involving the extraction of drugs by ether was the most suitable to use on poor quality forensic samples.
Source: PubMed
Preferred by: David Osselton
Comparison of methods for the analysis of tricyclic antidepressants in small whole blood samples.
Authors: Hughes, R.J. and Osselton, M.D.
Journal: Journal of analytical toxicology
Volume: 13
Issue: 2
Pages: 77-83
eISSN: 1945-2403
ISSN: 0146-4760
DOI: 10.1093/jat/13.2.77
Abstract:A variety of liquid-liquid and solid-phase extraction techniques have been compared for the extraction of tricyclic antidepressant drugs from small whole blood samples. Each of the procedures was evaluated with respect to extract cleanliness, extraction efficiency, and reproducibility. The three most efficient methods were compared on a variety of authentic whole blood case samples containing drugs at therapeutic and toxic levels. The results of the study indicated that a liquid-liquid extraction procedure involving the extraction of drugs by ether was the most suitable to use on poor quality forensic samples.
Source: Europe PubMed Central