Diet can exert both analgesic and pronociceptive effects in acute and chronic pain models: a systematic review of preclinical studies
Authors: Elma, Ö., Lebuf, E., Marnef, A.Q., Tümkaya Yilmaz, S., Coppieters, I., Clarys, P., Nijs, J., Malfliet, A. and Deliens, T.
Journal: Nutritional Neuroscience
Volume: 25
Issue: 10
Pages: 2195-2217
eISSN: 1476-8305
ISSN: 1028-415X
DOI: 10.1080/1028415X.2021.1934956
Abstract:Background: Although diet is an essential aspect of human health, the link between diet and pain is still not well understood. Preclinical animal research provides information to understand underlying mechanisms that allow identifying the needs for human research. Objectives: This study aims to give a systematic overview of the current evidence from preclinical studies regarding the analgesic and pronociceptive effects of various diets in non-neuropathic, non-cancer, or non-visceral acute and chronic pain models. Study Design: A systematic Review Setting: This study examined studies that investigate the analgesic and pronociceptive effects of various diets in non-neuropathic, non-cancer, or non-visceral acute and chronic pain models. Methods: This review was conducted following the PRISMA guidelines and was registered in PROSPERO with the registration number CRD42019133473. The certainty of evidence was examined by a modified GRADE approach. Results: After the screening process twenty-four eligible papers were included in this review. Nineteen studies examined acute pain, nine studies chronic inflammatory pain, and four studies assessed both acute and chronic pain models. Limitations: Due to the heterogeneity of the included studies, a meta-analysis was not included in this study. Conclusions: In animal models, excessive saturated, monounsaturated or omega-6 polyunsaturated fat ingestion and diets rich in fats and carbohydrates can decrease pain sensitivity in acute nociceptive pain, whereas it can induce mechanical allodynia and heat hyperalgesia in chronic inflammatory pain. Additionally, diets rich in anti-inflammatory ingredients, as well as a calorie-restricted diet can promote recovery from primary mechanical allodynia and heat hyperalgesia in chronic inflammatory pain.
Source: Scopus
Diet can exert both analgesic and pronociceptive effects in acute and chronic pain models: a systematic review of preclinical studies.
Authors: Elma, Ö., Lebuf, E., Marnef, A.Q., Tümkaya Yilmaz, S., Coppieters, I., Clarys, P., Nijs, J., Malfliet, A. and Deliens, T.
Journal: Nutr Neurosci
Volume: 25
Issue: 10
Pages: 2195-2217
eISSN: 1476-8305
DOI: 10.1080/1028415X.2021.1934956
Abstract:BACKGROUND: Although diet is an essential aspect of human health, the link between diet and pain is still not well understood. Preclinical animal research provides information to understand underlying mechanisms that allow identifying the needs for human research. OBJECTIVES: This study aims to give a systematic overview of the current evidence from preclinical studies regarding the analgesic and pronociceptive effects of various diets in non-neuropathic, non-cancer, or non-visceral acute and chronic pain models. STUDY DESIGN: A systematic Review. SETTING: This study examined studies that investigate the analgesic and pronociceptive effects of various diets in non-neuropathic, non-cancer, or non-visceral acute and chronic pain models. METHODS: This review was conducted following the PRISMA guidelines and was registered in PROSPERO with the registration number CRD42019133473. The certainty of evidence was examined by a modified GRADE approach. RESULTS: After the screening process twenty-four eligible papers were included in this review. Nineteen studies examined acute pain, nine studies chronic inflammatory pain, and four studies assessed both acute and chronic pain models. LIMITATIONS: Due to the heterogeneity of the included studies, a meta-analysis was not included in this study. CONCLUSIONS: In animal models, excessive saturated, monounsaturated or omega-6 polyunsaturated fat ingestion and diets rich in fats and carbohydrates can decrease pain sensitivity in acute nociceptive pain, whereas it can induce mechanical allodynia and heat hyperalgesia in chronic inflammatory pain. Additionally, diets rich in anti-inflammatory ingredients, as well as a calorie-restricted diet can promote recovery from primary mechanical allodynia and heat hyperalgesia in chronic inflammatory pain.
Source: PubMed
Diet can exert both analgesic and pronociceptive effects in acute and chronic pain models: a systematic review of preclinical studies
Authors: Elma, O., Lebuf, E., Marnef, A.Q., Tumkaya Yilmaz, S., Coppieters, I., Clarys, P., Nijs, J., Malfliet, A. and Deliens, T.
Journal: NUTRITIONAL NEUROSCIENCE
Volume: 25
Issue: 10
Pages: 2195-2217
eISSN: 1476-8305
ISSN: 1028-415X
DOI: 10.1080/1028415X.2021.1934956
Source: Web of Science (Lite)
Diet can exert both analgesic and pronociceptive effects in acute and chronic pain models: a systematic review of preclinical studies.
Authors: Elma, Ö., Lebuf, E., Marnef, A.Q., Tümkaya Yilmaz, S., Coppieters, I., Clarys, P., Nijs, J., Malfliet, A. and Deliens, T.
Journal: Nutritional neuroscience
Volume: 25
Issue: 10
Pages: 2195-2217
eISSN: 1476-8305
ISSN: 1028-415X
DOI: 10.1080/1028415x.2021.1934956
Abstract:Background
Although diet is an essential aspect of human health, the link between diet and pain is still not well understood. Preclinical animal research provides information to understand underlying mechanisms that allow identifying the needs for human research.Objectives
This study aims to give a systematic overview of the current evidence from preclinical studies regarding the analgesic and pronociceptive effects of various diets in non-neuropathic, non-cancer, or non-visceral acute and chronic pain models.Study design
A systematic Review.Setting
This study examined studies that investigate the analgesic and pronociceptive effects of various diets in non-neuropathic, non-cancer, or non-visceral acute and chronic pain models.Methods
This review was conducted following the PRISMA guidelines and was registered in PROSPERO with the registration number CRD42019133473. The certainty of evidence was examined by a modified GRADE approach.Results
After the screening process twenty-four eligible papers were included in this review. Nineteen studies examined acute pain, nine studies chronic inflammatory pain, and four studies assessed both acute and chronic pain models.Limitations
Due to the heterogeneity of the included studies, a meta-analysis was not included in this study.Conclusions
In animal models, excessive saturated, monounsaturated or omega-6 polyunsaturated fat ingestion and diets rich in fats and carbohydrates can decrease pain sensitivity in acute nociceptive pain, whereas it can induce mechanical allodynia and heat hyperalgesia in chronic inflammatory pain. Additionally, diets rich in anti-inflammatory ingredients, as well as a calorie-restricted diet can promote recovery from primary mechanical allodynia and heat hyperalgesia in chronic inflammatory pain.Source: Europe PubMed Central