Role of Genetic Polymorphisms in Breast Cancer

Pages: 165-190

ISBN: 9789813366985

DOI: 10.1007/978-981-33-6699-2_6

Abstract:

Of all cancers that affect women, the highest number of deaths results from breast cancer (BC). The tumorigenesis of BC is due to either chromosomal instability (CIN) or genetic polymorphisms of various genes involved in varied cellular processes. Numerous single-nucleotide polymorphisms (SNPs) have been identified and associated with an increased risk of BC. Some of these SNPs are considered potential markers of BC and thus are important for early diagnosis and personalized targeted therapy of BC. The present chapter summarizes the SNPs of various genes and their association with breast cancer.

Source: Scopus