CYP2B6 and OPRM1 gene variations predict methadone-related deaths
Authors: Bunten, H., Liang, W.J., Pounder, D., Seneviratne, C. and Osselton, M.D.
Journal: Addiction Biology
Volume: 16
Issue: 1
Pages: 142-144
eISSN: 1369-1600
ISSN: 1355-6215
DOI: 10.1111/j.1369-1600.2010.00274.x
Abstract:The largest proportion of methadone-associated deaths occurs during the drug induction phase. We analysed methadone-related fatalities for gene variations linked with methadone action. A significant association between high methadone concentrations and the CYP2B6*6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the risk of methadone fatality may be predetermined in part by the CYP2B6*6 allele. A significant correlation was also observed between post-mortem benzodiazepine concentrations and the OPRM1 A118G allele GA in methadone-related fatalities. Screening for these susceptibility variations prior to methadone prescription could assist in reducing the potential for serious adverse effects. © 2010 Society for the Study of Addiction.
Source: Scopus
CYP2B6 and OPRM1 gene variations predict methadone-related deaths.
Authors: Bunten, H., Liang, W.-J., Pounder, D., Seneviratne, C. and Osselton, M.D.
Journal: Addict Biol
Volume: 16
Issue: 1
Pages: 142-144
eISSN: 1369-1600
DOI: 10.1111/j.1369-1600.2010.00274.x
Abstract:The largest proportion of methadone-associated deaths occurs during the drug induction phase. We analysed methadone-related fatalities for gene variations linked with methadone action. A significant association between high methadone concentrations and the CYP2B6*6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the risk of methadone fatality may be predetermined in part by the CYP2B6*6 allele. A significant correlation was also observed between post-mortem benzodiazepine concentrations and the OPRM1 A118G allele GA in methadone-related fatalities. Screening for these susceptibility variations prior to methadone prescription could assist in reducing the potential for serious adverse effects.
Source: PubMed
CYP2B6 and OPRM1 gene variations predict methadone-related deaths
Authors: Bunten, H., Liang, W.-J., Pounder, D., Seneviratne, C. and Osselton, D.M.
Journal: Addiction Biology
Volume: 16
Pages: 142-144
ISSN: 1355-6215
DOI: 10.1038/clpt.2010.127
Abstract:The largest proportion of methadone-associated deaths occurs during the drug induction phase. We analysed methadone-related fatalities for gene variations linked with methadone action. A significant association between high methadone concentrations and the CYP2B6*6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the risk of methadone fatality may be predetermined in part by the CYP2B6*6 allele. A significant correlation was also observed between post-mortem benzodiazepine concentrations and the OPRM1 A118G allele GA in methadone-related fatalities. Screening for these susceptibility variations prior to methadone prescription could assist in reducing the potential for serious adverse effects.
Source: Manual
Preferred by: Wei-Jun Liang and David Osselton
CYP2B6 and OPRM1 gene variations predict methadone-related deaths.
Authors: Bunten, H., Liang, W.-J., Pounder, D., Seneviratne, C. and Osselton, M.D.
Journal: Addiction biology
Volume: 16
Issue: 1
Pages: 142-144
eISSN: 1369-1600
ISSN: 1355-6215
DOI: 10.1111/j.1369-1600.2010.00274.x
Abstract:The largest proportion of methadone-associated deaths occurs during the drug induction phase. We analysed methadone-related fatalities for gene variations linked with methadone action. A significant association between high methadone concentrations and the CYP2B6*6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the risk of methadone fatality may be predetermined in part by the CYP2B6*6 allele. A significant correlation was also observed between post-mortem benzodiazepine concentrations and the OPRM1 A118G allele GA in methadone-related fatalities. Screening for these susceptibility variations prior to methadone prescription could assist in reducing the potential for serious adverse effects.
Source: Europe PubMed Central