CYP2B6 and OPRM1 gene variations predict methadone-related deaths

Authors: Bunten, H., Liang, W.J., Pounder, D., Seneviratne, C. and Osselton, M.D.

Journal: Addiction Biology

Volume: 16

Issue: 1

Pages: 142-144

eISSN: 1369-1600

ISSN: 1355-6215

DOI: 10.1111/j.1369-1600.2010.00274.x

Abstract:

The largest proportion of methadone-associated deaths occurs during the drug induction phase. We analysed methadone-related fatalities for gene variations linked with methadone action. A significant association between high methadone concentrations and the CYP2B6*6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the risk of methadone fatality may be predetermined in part by the CYP2B6*6 allele. A significant correlation was also observed between post-mortem benzodiazepine concentrations and the OPRM1 A118G allele GA in methadone-related fatalities. Screening for these susceptibility variations prior to methadone prescription could assist in reducing the potential for serious adverse effects. © 2010 Society for the Study of Addiction.

Source: Scopus

CYP2B6 and OPRM1 gene variations predict methadone-related deaths.

Authors: Bunten, H., Liang, W.-J., Pounder, D., Seneviratne, C. and Osselton, M.D.

Journal: Addict Biol

Volume: 16

Issue: 1

Pages: 142-144

eISSN: 1369-1600

DOI: 10.1111/j.1369-1600.2010.00274.x

Abstract:

The largest proportion of methadone-associated deaths occurs during the drug induction phase. We analysed methadone-related fatalities for gene variations linked with methadone action. A significant association between high methadone concentrations and the CYP2B6*6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the risk of methadone fatality may be predetermined in part by the CYP2B6*6 allele. A significant correlation was also observed between post-mortem benzodiazepine concentrations and the OPRM1 A118G allele GA in methadone-related fatalities. Screening for these susceptibility variations prior to methadone prescription could assist in reducing the potential for serious adverse effects.

Source: PubMed

CYP2B6 and OPRM1 gene variations predict methadone-related deaths

Authors: Bunten, H., Liang, W.-J., Pounder, D., Seneviratne, C. and Osselton, D.M.

Journal: Addiction Biology

Volume: 16

Pages: 142-144

ISSN: 1355-6215

DOI: 10.1038/clpt.2010.127

Abstract:

The largest proportion of methadone-associated deaths occurs during the drug induction phase. We analysed methadone-related fatalities for gene variations linked with methadone action. A significant association between high methadone concentrations and the CYP2B6*6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the risk of methadone fatality may be predetermined in part by the CYP2B6*6 allele. A significant correlation was also observed between post-mortem benzodiazepine concentrations and the OPRM1 A118G allele GA in methadone-related fatalities. Screening for these susceptibility variations prior to methadone prescription could assist in reducing the potential for serious adverse effects.

Source: Manual

Preferred by: Wei-Jun Liang and David Osselton

CYP2B6 and OPRM1 gene variations predict methadone-related deaths.

Authors: Bunten, H., Liang, W.-J., Pounder, D., Seneviratne, C. and Osselton, M.D.

Journal: Addiction biology

Volume: 16

Issue: 1

Pages: 142-144

eISSN: 1369-1600

ISSN: 1355-6215

DOI: 10.1111/j.1369-1600.2010.00274.x

Abstract:

The largest proportion of methadone-associated deaths occurs during the drug induction phase. We analysed methadone-related fatalities for gene variations linked with methadone action. A significant association between high methadone concentrations and the CYP2B6*6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the risk of methadone fatality may be predetermined in part by the CYP2B6*6 allele. A significant correlation was also observed between post-mortem benzodiazepine concentrations and the OPRM1 A118G allele GA in methadone-related fatalities. Screening for these susceptibility variations prior to methadone prescription could assist in reducing the potential for serious adverse effects.

Source: Europe PubMed Central