Variations in metabolic response to TPN are influenced more by sex than by light exposure
Authors: Harrison, A., Khashu, M., Friel, J., Lavoie, J.C. and Chessex, P.
Journal: Journal of Pediatric Gastroenterology and Nutrition
Volume: 45
Issue: 5
Pages: 577-581
ISSN: 0277-2116
DOI: 10.1097/MPG.0b013e318074b851
Abstract:BACKGROUND: Failure to protect total parenteral nutrition (TPN) solutions from ambient light induces the generation of peroxides, which contributes to the oxidation of several amino acids. We hypothesized that photo-protection improves the metabolic response to TPN. AIM: To study the effects of photo-protecting TPN on urinary nitrogen and vitamin C excretion and to evaluate in premature infants the influence of sex. PATIENTS AND METHODS: Premature infants were randomized to receive from birth light-exposed (LE) or light-protected (LP) TPN. Upon reaching full TPN, parenteral nutrient intakes were correlated with normalized urinary nitrogen and vitamin C concentrations. RESULTS: No differences were observed between LE and LP. However, sex-related differences were observed in nitrogen and vitamin C handling. In boys, 50% of the nitrogen loss was explained by parenteral amino acid intake, whereas in girls, no correlation was found. The inverse correlation observed between intake and urinary excretion only in girls suggests a state of greater vitamin C utilization in girls. CONCLUSIONS: These results demonstrate that sex-related differences in nitrogen/protein metabolism reported during enteral nutrition are seen during TPN as well. Sex is an important variable that will need to be taken into account in future studies evaluating the potential clinical effects of photo-protecting TPN. © 2007 Lippincott Williams & Wilkins, Inc.
Source: Scopus
Variations in metabolic response to TPN are influenced more by sex than by light exposure.
Authors: Harrison, A., Khashu, M., Friel, J., Lavoie, J.-C. and Chessex, P.
Journal: J Pediatr Gastroenterol Nutr
Volume: 45
Issue: 5
Pages: 577-581
eISSN: 1536-4801
DOI: 10.1097/MPG.0b013e318074b851
Abstract:BACKGROUND: Failure to protect total parenteral nutrition (TPN) solutions from ambient light induces the generation of peroxides, which contributes to the oxidation of several amino acids. We hypothesized that photo-protection improves the metabolic response to TPN. AIM: To study the effects of photo-protecting TPN on urinary nitrogen and vitamin C excretion and to evaluate in premature infants the influence of sex. PATIENTS AND METHODS: Premature infants were randomized to receive from birth light-exposed (LE) or light-protected (LP) TPN. Upon reaching full TPN, parenteral nutrient intakes were correlated with normalized urinary nitrogen and vitamin C concentrations. RESULTS: No differences were observed between LE and LP. However, sex-related differences were observed in nitrogen and vitamin C handling. In boys, 50% of the nitrogen loss was explained by parenteral amino acid intake, whereas in girls, no correlation was found. The inverse correlation observed between intake and urinary excretion only in girls suggests a state of greater vitamin C utilization in girls. CONCLUSIONS: These results demonstrate that sex-related differences in nitrogen/protein metabolism reported during enteral nutrition are seen during TPN as well. Sex is an important variable that will need to be taken into account in future studies evaluating the potential clinical effects of photo-protecting TPN.
Source: PubMed
Preferred by: Minesh Khashu
Variations in metabolic response to TPN are influenced more by sex than by light exposure
Authors: Harrison, A., Khashu, M., Friel, J., Lavoie, J.-C. and Chessex, P.
Journal: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
Volume: 45
Issue: 5
Pages: 577-581
eISSN: 1536-4801
ISSN: 0277-2116
DOI: 10.1097/MPG.0b013e318074b851
Source: Web of Science (Lite)
Variations in metabolic response to TPN are influenced more by sex than by light exposure.
Authors: Harrison, A., Khashu, M., Friel, J., Lavoie, J.-C. and Chessex, P.
Journal: Journal of pediatric gastroenterology and nutrition
Volume: 45
Issue: 5
Pages: 577-581
eISSN: 1536-4801
ISSN: 0277-2116
DOI: 10.1097/mpg.0b013e318074b851
Abstract:Background
Failure to protect total parenteral nutrition (TPN) solutions from ambient light induces the generation of peroxides, which contributes to the oxidation of several amino acids. We hypothesized that photo-protection improves the metabolic response to TPN.Aim
To study the effects of photo-protecting TPN on urinary nitrogen and vitamin C excretion and to evaluate in premature infants the influence of sex.Patients and methods
Premature infants were randomized to receive from birth light-exposed (LE) or light-protected (LP) TPN. Upon reaching full TPN, parenteral nutrient intakes were correlated with normalized urinary nitrogen and vitamin C concentrations.Results
No differences were observed between LE and LP. However, sex-related differences were observed in nitrogen and vitamin C handling. In boys, 50% of the nitrogen loss was explained by parenteral amino acid intake, whereas in girls, no correlation was found. The inverse correlation observed between intake and urinary excretion only in girls suggests a state of greater vitamin C utilization in girls.Conclusions
These results demonstrate that sex-related differences in nitrogen/protein metabolism reported during enteral nutrition are seen during TPN as well. Sex is an important variable that will need to be taken into account in future studies evaluating the potential clinical effects of photo-protecting TPN.Source: Europe PubMed Central