Impact of shielding parenteral nutrition from light on routine monitoring of blood glucose and triglyceride levels in preterm neonates
Authors: Khashu, M., Harrison, A., Lalari, V., Lavoie, J.C. and Chessex, P.
Journal: Archives of Disease in Childhood: Fetal and Neonatal Edition
Volume: 94
Issue: 2
eISSN: 1468-2052
ISSN: 1359-2998
DOI: 10.1136/adc.2007.135327
Abstract:Background: Premature infants are vulnerable to complications related to oxidative stress. Exposure to light increases oxidation products in solutions of total parenteral nutrition (TPN) such as lipid peroxides and hydrogen peroxide. Oxidative stress impairs glucose uptake and affects lipid metabolism. Hypothesis: products of photo-oxidation contaminating TPN affect lipid metabolism. Objective: Evaluate the effect of photoprotection of TPN in preterm infants on plasma glucose and triglyceride (TG) concentrations. Design: Secondary analysis of a prospective study allocating preterm infants to light-exposed (LE, n = 32) or light-protected (LP, n = 27) TPN. Setting: Level III NICU referral centre for patients of British Columbia. Patients: Preterm infants requiring TPN. Interventions and outcome measures: TG and blood glucose measured during routine monitoring while on full TPN were compared between LE and LP. Results: Clinical characteristics were similar between the two groups (gestational age 28 ± 1 wk; birth weight: 1.0 ± 0.1 kg). Nutrient intakes from TPN and from minimal enteral nutrition were comparable between LE and LP. Blood glucose was higher in preterm infants receiving LE (p<0.001). The accumulation of TG with increasing lipid intake was twice as high with LE accounting for significantly higher TG levels on days 8 and 9(p<0.05). Conclusions: Failure to photoprotect TPN may cause alterations in intermediary metabolism. Shielding TPN from light provides a potential benefit for preterm infants by avoiding hypertriglyceridaemia allowing for increased substrate delivery.
Source: Scopus
Impact of shielding parenteral nutrition from light on routine monitoring of blood glucose and triglyceride levels in preterm neonates.
Authors: Khashu, M., Harrison, A., Lalari, V., Lavoie, J.-C. and Chessex, P.
Journal: Arch Dis Child Fetal Neonatal Ed
Volume: 94
Issue: 2
Pages: F111-F115
eISSN: 1468-2052
DOI: 10.1136/adc.2007.135327
Abstract:BACKGROUND: Premature infants are vulnerable to complications related to oxidative stress. Exposure to light increases oxidation products in solutions of total parenteral nutrition (TPN) such as lipid peroxides and hydrogen peroxide. Oxidative stress impairs glucose uptake and affects lipid metabolism. HYPOTHESIS: products of photo-oxidation contaminating TPN affect lipid metabolism. OBJECTIVE: Evaluate the effect of photoprotection of TPN in preterm infants on plasma glucose and triglyceride (TG) concentrations. DESIGN: Secondary analysis of a prospective study allocating preterm infants to light-exposed (LE, n = 32) or light-protected (LP, n = 27) TPN. SETTING: Level III NICU referral centre for patients of British Columbia. PATIENTS: Preterm infants requiring TPN. INTERVENTIONS AND OUTCOME MEASURES: TG and blood glucose measured during routine monitoring while on full TPN were compared between LE and LP. RESULTS: Clinical characteristics were similar between the two groups (gestational age 28+/-1 wk; birth weight: 1.0+/-0.1 kg). Nutrient intakes from TPN and from minimal enteral nutrition were comparable between LE and LP. Blood glucose was higher in preterm infants receiving LE (p<0.001). The accumulation of TG with increasing lipid intake was twice as high with LE accounting for significantly higher TG levels on days 8 and 9 (p<0.05). CONCLUSIONS: Failure to photoprotect TPN may cause alterations in intermediary metabolism. Shielding TPN from light provides a potential benefit for preterm infants by avoiding hypertriglyceridaemia allowing for increased substrate delivery.
Source: PubMed
Preferred by: Minesh Khashu
Impact of shielding parenteral nutrition from light on routine monitoring of blood glucose and triglyceride levels in preterm neonates
Authors: Khashu, M., Harrison, A., Lalari, V., Lavoie, J.-C. and Chessex, P.
Journal: ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
Volume: 94
Issue: 2
Pages: F111-F115
eISSN: 1468-2052
ISSN: 1359-2998
DOI: 10.1136/adc.2007.135327
Source: Web of Science (Lite)
Impact of shielding parenteral nutrition from light on routine monitoring of blood glucose and triglyceride levels in preterm neonates.
Authors: Khashu, M., Harrison, A., Lalari, V., Lavoie, J.-C. and Chessex, P.
Journal: Archives of disease in childhood. Fetal and neonatal edition
Volume: 94
Issue: 2
Pages: F111-F115
eISSN: 1468-2052
ISSN: 1359-2998
DOI: 10.1136/adc.2007.135327
Abstract:Background
Premature infants are vulnerable to complications related to oxidative stress. Exposure to light increases oxidation products in solutions of total parenteral nutrition (TPN) such as lipid peroxides and hydrogen peroxide. Oxidative stress impairs glucose uptake and affects lipid metabolism.Hypothesis
products of photo-oxidation contaminating TPN affect lipid metabolism.Objective
Evaluate the effect of photoprotection of TPN in preterm infants on plasma glucose and triglyceride (TG) concentrations.Design
Secondary analysis of a prospective study allocating preterm infants to light-exposed (LE, n = 32) or light-protected (LP, n = 27) TPN.Setting
Level III NICU referral centre for patients of British Columbia.Patients
Preterm infants requiring TPN.Interventions and outcome measures
TG and blood glucose measured during routine monitoring while on full TPN were compared between LE and LP.Results
Clinical characteristics were similar between the two groups (gestational age 28+/-1 wk; birth weight: 1.0+/-0.1 kg). Nutrient intakes from TPN and from minimal enteral nutrition were comparable between LE and LP. Blood glucose was higher in preterm infants receiving LE (p<0.001). The accumulation of TG with increasing lipid intake was twice as high with LE accounting for significantly higher TG levels on days 8 and 9 (p<0.05).Conclusions
Failure to photoprotect TPN may cause alterations in intermediary metabolism. Shielding TPN from light provides a potential benefit for preterm infants by avoiding hypertriglyceridaemia allowing for increased substrate delivery.Source: Europe PubMed Central