Patterns of progression, treatment of progressive disease and post-progression survival in the New EPOC study

Authors: Pugh, S.A., Hickish, T. et al.

Journal: British Journal of Cancer

Volume: 115

Issue: 4

Pages: 420-424

eISSN: 1532-1827

ISSN: 0007-0920

DOI: 10.1038/bjc.2016.208

Abstract:

Background:The addition of cetuximab (CTX) to perioperative chemotherapy (CT) for operable colorectal liver metastases resulted in a shorter progression-free survival. Details of disease progression are described to further inform the primary study outcome.Methods:A total of 257 KRAS wild-type patients were randomised to CT alone or CT with CTX. Data regarding sites and treatment of progressive disease were obtained for the 109 (CT n=48, CT and CTX n=61) patients with progressive disease at the cut-off date for analysis of November 2012.Results:The liver was the most frequent site of progression (CT 67% (32/48); CT and CTX 66% (40/61)). A higher proportion of patients in the CT and group had multiple sites of progressive disease (CT 8%, 4/48; CT and CTX 23%, 14/61 P=0.04). Further treatment for progressive disease is known for 84 patients of whom 69 received further CT, most frequently irinotecan based. Twenty-two patients, 11 in each arm, received CTX as a further line agent.Conclusions:Both the distribution of progressive disease and further treatment are as expected for such a cohort. The pattern of disease progression seen is consistent with failure of systemic micrometastatic disease control rather than failure of local disease control following liver surgery.

https://eprints.bournemouth.ac.uk/24880/

Source: Scopus

Patterns of progression, treatment of progressive disease and post-progression survival in the New EPOC study.

Authors: Pugh, S.A., Hickish, T. et al.

Journal: Br J Cancer

Volume: 115

Issue: 4

Pages: 420-424

eISSN: 1532-1827

DOI: 10.1038/bjc.2016.208

Abstract:

BACKGROUND: The addition of cetuximab (CTX) to perioperative chemotherapy (CT) for operable colorectal liver metastases resulted in a shorter progression-free survival. Details of disease progression are described to further inform the primary study outcome. METHODS: A total of 257 KRAS wild-type patients were randomised to CT alone or CT with CTX. Data regarding sites and treatment of progressive disease were obtained for the 109 (CT n=48, CT and CTX n=61) patients with progressive disease at the cut-off date for analysis of November 2012. RESULTS: The liver was the most frequent site of progression (CT 67% (32/48); CT and CTX 66% (40/61)). A higher proportion of patients in the CT and group had multiple sites of progressive disease (CT 8%, 4/48; CT and CTX 23%, 14/61 P=0.04). Further treatment for progressive disease is known for 84 patients of whom 69 received further CT, most frequently irinotecan based. Twenty-two patients, 11 in each arm, received CTX as a further line agent. CONCLUSIONS: Both the distribution of progressive disease and further treatment are as expected for such a cohort. The pattern of disease progression seen is consistent with failure of systemic micrometastatic disease control rather than failure of local disease control following liver surgery.

https://eprints.bournemouth.ac.uk/24880/

Source: PubMed

Patterns of progression, treatment of progressive disease and post-progression survival in the New EPOC study

Authors: Pugh, S.A., Hickish, T. et al.

Journal: BRITISH JOURNAL OF CANCER

Volume: 115

Issue: 4

Pages: 420-424

eISSN: 1532-1827

ISSN: 0007-0920

DOI: 10.1038/bjc.2016.208

https://eprints.bournemouth.ac.uk/24880/

Source: Web of Science (Lite)

Patterns of progression, treatment of progressive disease and post-progression survival in the New EPOC study

Authors: Pugh, S.A., Hickish, T. et al.

Journal: British Journal of Cancer

Volume: 115

Issue: 4

Pages: 420-424

eISSN: 1532-1827

ISSN: 0007-0920

DOI: 10.1038/bjc.2016.208

Abstract:

Background:The addition of cetuximab (CTX) to perioperative chemotherapy (CT) for operable colorectal liver metastases resulted in a shorter progression-free survival. Details of disease progression are described to further inform the primary study outcome.Methods:A total of 257 KRAS wild-type patients were randomised to CT alone or CT with CTX. Data regarding sites and treatment of progressive disease were obtained for the 109 (CT n=48, CT and CTX n=61) patients with progressive disease at the cut-off date for analysis of November 2012.Results:The liver was the most frequent site of progression (CT 67% (32/48); CT and CTX 66% (40/61)). A higher proportion of patients in the CT and group had multiple sites of progressive disease (CT 8%, 4/48; CT and CTX 23%, 14/61 P=0.04). Further treatment for progressive disease is known for 84 patients of whom 69 received further CT, most frequently irinotecan based. Twenty-two patients, 11 in each arm, received CTX as a further line agent.Conclusions:Both the distribution of progressive disease and further treatment are as expected for such a cohort. The pattern of disease progression seen is consistent with failure of systemic micrometastatic disease control rather than failure of local disease control following liver surgery.

https://eprints.bournemouth.ac.uk/24880/

Source: Manual

Preferred by: Tamas Hickish

Patterns of progression, treatment of progressive disease and post-progression survival in the New EPOC study.

Authors: Pugh, S.A., Hickish, T. et al.

Journal: British journal of cancer

Volume: 115

Issue: 4

Pages: 420-424

eISSN: 1532-1827

ISSN: 0007-0920

DOI: 10.1038/bjc.2016.208

Abstract:

Background

The addition of cetuximab (CTX) to perioperative chemotherapy (CT) for operable colorectal liver metastases resulted in a shorter progression-free survival. Details of disease progression are described to further inform the primary study outcome.

Methods

A total of 257 KRAS wild-type patients were randomised to CT alone or CT with CTX. Data regarding sites and treatment of progressive disease were obtained for the 109 (CT n=48, CT and CTX n=61) patients with progressive disease at the cut-off date for analysis of November 2012.

Results

The liver was the most frequent site of progression (CT 67% (32/48); CT and CTX 66% (40/61)). A higher proportion of patients in the CT and group had multiple sites of progressive disease (CT 8%, 4/48; CT and CTX 23%, 14/61 P=0.04). Further treatment for progressive disease is known for 84 patients of whom 69 received further CT, most frequently irinotecan based. Twenty-two patients, 11 in each arm, received CTX as a further line agent.

Conclusions

Both the distribution of progressive disease and further treatment are as expected for such a cohort. The pattern of disease progression seen is consistent with failure of systemic micrometastatic disease control rather than failure of local disease control following liver surgery.

https://eprints.bournemouth.ac.uk/24880/

Source: Europe PubMed Central

Patterns of progression, treatment of progressive disease and post-progression survival in the New EPOC study.

Authors: Pugh, S.A., Hickish, T.F. et al.

Journal: British Journal of Cancer

Volume: 115

Issue: 4

Pages: 420-424

ISSN: 0007-0920

Abstract:

BACKGROUND: The addition of cetuximab (CTX) to perioperative chemotherapy (CT) for operable colorectal liver metastases resulted in a shorter progression-free survival. Details of disease progression are described to further inform the primary study outcome. METHODS: A total of 257 KRAS wild-type patients were randomised to CT alone or CT with CTX. Data regarding sites and treatment of progressive disease were obtained for the 109 (CT n=48, CT and CTX n=61) patients with progressive disease at the cut-off date for analysis of November 2012. RESULTS: The liver was the most frequent site of progression (CT 67% (32/48); CT and CTX 66% (40/61)). A higher proportion of patients in the CT and group had multiple sites of progressive disease (CT 8%, 4/48; CT and CTX 23%, 14/61 P=0.04). Further treatment for progressive disease is known for 84 patients of whom 69 received further CT, most frequently irinotecan based. Twenty-two patients, 11 in each arm, received CTX as a further line agent. CONCLUSIONS: Both the distribution of progressive disease and further treatment are as expected for such a cohort. The pattern of disease progression seen is consistent with failure of systemic micrometastatic disease control rather than failure of local disease control following liver surgery.

https://eprints.bournemouth.ac.uk/24880/

Source: BURO EPrints