Vitamin A is systemically bioavailable after intratracheal administration with surfactant in an animal model of newborn respiratory distress
Authors: Singh, A.J., Bronshtein, V., Khashu, M., Lee, K., Potts, J.E., Friel, J. and Chessex, P.
Journal: Pediatric Research
Volume: 67
Issue: 6
Pages: 619-623
eISSN: 1530-0447
ISSN: 0031-3998
DOI: 10.1203/PDR.0b013e3181da8fe8
Abstract:Chronic lung disease (CLD) is a major cause of long-term morbidity in extremely LBW infants with respiratory distress syndrome. Parenteral vitamin A administration decreases the risk of CLD. We tested the hypothesis that intratracheal vitamin A administration with surfactant is systemically bioavailable without interfering with the functional properties of exogenous surfactant. Newborn piglets were ventilated with 100% FiO2 and sequential saline lavage induced respiratory distress syndrome. During lung injury induction, ventilator changes were allowed, but none were made following treatment allocation. Animals were assigned by chance in a blinded control trial to three groups: I = control; II = surfactant; III = surfactant + vitamin A. Hemodynamics, lung mechanics, and blood gases were measured following instrumentation, pre-and posttreatment for 4 h, at which time the liver was sampled for retinol determination. All parameters improved in animals receiving surfactant. A significant interaction existed between time and group for PaO2 and alveolar-arterial oxygen difference (A-aDO2). Hepatic levels of retinol were higher (p < 0.001) in animals receiving retinyl acetate. Intratracheal administration of surfactant + vitamin A did not alter the beneficial effects of surfactant on lung compliance and gas exchange. Intratracheal Vitamin A was associated with rapid hepatic uptake. Further studies are warranted. © 2010 International Pediatric Research Foundation, Inc.
Source: Scopus
Vitamin A is systemically bioavailable after intratracheal administration with surfactant in an animal model of newborn respiratory distress.
Authors: Singh, A.J., Bronshtein, V., Khashu, M., Lee, K., Potts, J.E., Friel, J. and Chessex, P.
Journal: Pediatr Res
Volume: 67
Issue: 6
Pages: 619-623
eISSN: 1530-0447
DOI: 10.1203/PDR.0b013e3181da8fe8
Abstract:Chronic lung disease (CLD) is a major cause of long-term morbidity in extremely LBW infants with respiratory distress syndrome. Parenteral vitamin A administration decreases the risk of CLD. We tested the hypothesis that intratracheal vitamin A administration with surfactant is systemically bioavailable without interfering with the functional properties of exogenous surfactant. Newborn piglets were ventilated with 100% FiO2 and sequential saline lavage induced respiratory distress syndrome. During lung injury induction, ventilator changes were allowed, but none were made following treatment allocation. Animals were assigned by chance in a blinded control trial to three groups: I=control; II=surfactant; III=surfactant+vitamin A. Hemodynamics, lung mechanics, and blood gases were measured following instrumentation, pre- and posttreatment for 4 h, at which time the liver was sampled for retinol determination. All parameters improved in animals receiving surfactant. A significant interaction existed between time and group for PaO2 and alveolar-arterial oxygen difference (A-aDO2). Hepatic levels of retinol were higher (p<0.001) in animals receiving retinyl acetate. Intratracheal administration of surfactant+vitamin A did not alter the beneficial effects of surfactant on lung compliance and gas exchange. Intratracheal Vitamin A was associated with rapid hepatic uptake. Further studies are warranted.
Source: PubMed
Preferred by: Minesh Khashu
Vitamin A Is Systemically Bioavailable After Intratracheal Administration With Surfactant in an Animal Model of Newborn Respiratory Distress
Authors: Singh, A.J., Bronshtein, V., Khashu, M., Lee, K., Potts, J.E., Friel, J. and Chessex, P.
Journal: PEDIATRIC RESEARCH
Volume: 67
Issue: 6
Pages: 619-623
ISSN: 0031-3998
DOI: 10.1203/PDR.0b013e3181da8fe8
Source: Web of Science (Lite)
Vitamin A is systemically bioavailable after intratracheal administration with surfactant in an animal model of newborn respiratory distress.
Authors: Singh, A.J., Bronshtein, V., Khashu, M., Lee, K., Potts, J.E., Friel, J. and Chessex, P.
Journal: Pediatric research
Volume: 67
Issue: 6
Pages: 619-623
eISSN: 1530-0447
ISSN: 0031-3998
DOI: 10.1203/pdr.0b013e3181da8fe8
Abstract:Chronic lung disease (CLD) is a major cause of long-term morbidity in extremely LBW infants with respiratory distress syndrome. Parenteral vitamin A administration decreases the risk of CLD. We tested the hypothesis that intratracheal vitamin A administration with surfactant is systemically bioavailable without interfering with the functional properties of exogenous surfactant. Newborn piglets were ventilated with 100% FiO2 and sequential saline lavage induced respiratory distress syndrome. During lung injury induction, ventilator changes were allowed, but none were made following treatment allocation. Animals were assigned by chance in a blinded control trial to three groups: I=control; II=surfactant; III=surfactant+vitamin A. Hemodynamics, lung mechanics, and blood gases were measured following instrumentation, pre- and posttreatment for 4 h, at which time the liver was sampled for retinol determination. All parameters improved in animals receiving surfactant. A significant interaction existed between time and group for PaO2 and alveolar-arterial oxygen difference (A-aDO2). Hepatic levels of retinol were higher (p<0.001) in animals receiving retinyl acetate. Intratracheal administration of surfactant+vitamin A did not alter the beneficial effects of surfactant on lung compliance and gas exchange. Intratracheal Vitamin A was associated with rapid hepatic uptake. Further studies are warranted.
Source: Europe PubMed Central