Lateral orbitofrontal cortex anticipates choices and integrates prior with current information

Authors: Nogueira, R., Abolafia, J., Drugowitsch, J., Balaguer-Ballester, E., Sanchez-Vives, M.V. and Moreno-Bote, R.

http://eprints.bournemouth.ac.uk/28369/

Journal: Nature Communications

Publisher: Nature Publishing Group: Nature Communications

ISSN: 2041-1723

This data was imported from PubMed:

Authors: Nogueira, R., Abolafia, J.M., Drugowitsch, J., Balaguer-Ballester, E., Sanchez-Vives, M.V. and Moreno-Bote, R.

http://eprints.bournemouth.ac.uk/28369/

Journal: Nat Commun

Volume: 8

Pages: 14823

eISSN: 2041-1723

DOI: 10.1038/ncomms14823

Adaptive behavior requires integrating prior with current information to anticipate upcoming events. Brain structures related to this computation should bring relevant signals from the recent past into the present. Here we report that rats can integrate the most recent prior information with sensory information, thereby improving behavior on a perceptual decision-making task with outcome-dependent past trial history. We find that anticipatory signals in the orbitofrontal cortex about upcoming choice increase over time and are even present before stimulus onset. These neuronal signals also represent the stimulus and relevant second-order combinations of past state variables. The encoding of choice, stimulus and second-order past state variables resides, up to movement onset, in overlapping populations. The neuronal representation of choice before stimulus onset and its build-up once the stimulus is presented suggest that orbitofrontal cortex plays a role in transforming immediate prior and stimulus information into choices using a compact state-space representation.

This data was imported from Scopus:

Authors: Nogueira, R., Abolafia, J.M., Drugowitsch, J., Balaguer-Ballester, E., Sanchez-Vives, M.V. and Moreno-Bote, R.

http://eprints.bournemouth.ac.uk/28369/

Journal: Nature Communications

Volume: 8

eISSN: 2041-1723

DOI: 10.1038/ncomms14823

© The Author(s) 2017. Adaptive behavior requires integrating prior with current information to anticipate upcoming events. Brain structures related to this computation should bring relevant signals from the recent past into the present. Here we report that rats can integrate the most recent prior information with sensory information, thereby improving behavior on a perceptual decision-making task with outcome-dependent past trial history. We find that anticipatory signals in the orbitofrontal cortex about upcoming choice increase over time and are even present before stimulus onset. These neuronal signals also represent the stimulus and relevant second-order combinations of past state variables. The encoding of choice, stimulus and second-order past state variables resides, up to movement onset, in overlapping populations. The neuronal representation of choice before stimulus onset and its build-up once the stimulus is presented suggest that orbitofrontal cortex plays a role in transforming immediate prior and stimulus information into choices using a compact state-space representation.

This data was imported from Web of Science (Lite):

Authors: Nogueira, R., Abolafia, J.M., Drugowitsch, J., Balaguer-Ballester, E., Sanchez-Vives, M.V. and Moreno-Bote, R.

http://eprints.bournemouth.ac.uk/28369/

Journal: NATURE COMMUNICATIONS

Volume: 8

ISSN: 2041-1723

DOI: 10.1038/ncomms14823

The data on this page was last updated at 05:16 on April 4, 2020.