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Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Authors: Dunlop, M.G., Hickish, T. et al.

Journal: Nature Genetics

eISSN: 1546-1718

ISSN: 1061-4036

Source: Scopus

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

Authors: Dunlop, M.G. et al.

Journal: Nat Genet

Volume: 44

Issue: 7

Pages: 770-776

eISSN: 1546-1718

DOI: 10.1038/ng.2293

Abstract:

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

Source: PubMed

Preferred by: Tamas Hickish

Common variation near <i>CDKN1A</i>, <i>POLD3</i> and <i>SHROOM2</i> influences colorectal cancer risk

Authors: Dunlop, M.G. et al.

Journal: NATURE GENETICS

Volume: 44

Issue: 7

Pages: 770-U197

eISSN: 1546-1718

ISSN: 1061-4036

DOI: 10.1038/ng.2293

Source: Web of Science (Lite)

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

Authors: Dunlop, M.G. et al.

Journal: Nature genetics

Volume: 44

Issue: 7

Pages: 770-776

eISSN: 1546-1718

ISSN: 1061-4036

DOI: 10.1038/ng.2293

Abstract:

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

Source: Europe PubMed Central