POLYMERASE CHAIN REACTION FOR DETECTION OF DISSEMINATION IN GASTRIC LYMPHOMA

Authors: Cunningham, D., Rosin, R.D., Baron, J.H., Hickish, T., Sauven, P., Farrell, P.T. and Isaacson, P.

Journal: The Lancet

Volume: 333

Issue: 8640

Pages: 695-697

ISSN: 0140-6736

DOI: 10.1016/S0140-6736(89)92208-3

Abstract:

The polymerase chain reaction (PCR) was used to detect malignant lymphoma cells with the bcl-2 gene rearrangement in the peritoneal washings and bone marrow of a patient with an apparently localised gastric lymphoma. After four courses of cytotoxic drug treatment the cells could no longer be detected in either site. PCR is a useful addition to the staging investigations of non-Hodgkin lymphoma and can also be used to monitor response to treatment. © 1989.

Source: Scopus