Vitamin D deficiency and muscle strength in male alcoholics
Authors: Hickish, T., Colston, K.W., Bland, J.M. and Maxwell, J.D.
Journal: Clinical Science
Volume: 77
Issue: 2
Pages: 177-182
ISSN: 0143-5221
DOI: 10.1042/cs0770171
Abstract:To investigate atrial natriuretic factor (ANF) and its relationship to the renin system in diabetes, we measured plasma immunoreactive ANF and plasma renin activity (PRA) in 27 non-ketotic diabetic patients without evidence of cardiac or overt renal disease, and compared them with 26 age- and sex-matched normal subjects. Diabetic patients were divided prospectively into poor (PGC, n = 14) or moderate (MGC, n = 13) glycaemic control depending on their concurrent plasma glycohaemoglobin (HbA1) levels (> 9% or < 9%, respectively). Plasma ANF was elevated in PGC diabetic patients (15.7 ± 1.8 fmol/ml, mean ± SEM) compared with MGC diabetics (9.9 ± 0.8 fmol/ml, P < 0.001) and normal subjects (10.1 ± 1.3 fmol/ml, P < 0.05). In contrast, PRA was lower in the PGC diabetic patients (1.3 ± 0.3 pmol of angiotensin I h-1 ml-1) compared with the other groups (2.5 ± 0.5 and 2.1 ± 0.2 pmol of angiotensin I h-1 ml-1, P < 0.05). Diabetic groups had proportionally more patients with high prorenin values (over 30 ng h-1 ml-1) than the normal group, but there was no difference between the diabetic groups. Among the diabetic patients, ANF was directly related to HbA1 (r = 0.49, P < 0.005) and urinary albumin excretion ( r = 0.40, P < 0.02), and was inversely related to PRA (r = -0.36, P < 0.04) and plasma creatinine (r = -0.42, P < 0.02). Systolic blood pressure was greater in PGC diabetic patients [133 ± 5 mmHg (17.7 ± 0.7 kPa()] than in MGC diabetic patients (117 ± 4 (15.6 ± 0.5 kPa), P < 0.05] and normal subjects [121 ± 3 (16.1 ± 0.4 kPa), P < 0.05]. Diastolic pressure was not significantly different among the groups. The directionally opposite changes in plasma ANF and plasma renin in PGC diabetic patients may reflect a normal response to expansion of intravascular volume. It remains to be established whether these changes are factors in the early renal dysfunction of diabetes mellitus.
Source: Scopus
Preferred by: Tamas Hickish