Evolving patterns in the presentation of coeliac disease over the last 25 years
Authors: Stroud, C., Almilaji, O., Nicholas, D., Kirkham, S., Surgenor, S.L., Williams, I. and Snook, J.
Journal: Frontline Gastroenterology
Volume: 11
Issue: 2
Pages: 98-103
eISSN: 2041-4145
ISSN: 2041-4137
DOI: 10.1136/flgastro-2018-101170
Abstract:Objective To document changes in the clinical features of coeliac disease (CD) at presentation over the last 25 years. Design Observational study. Patients 802 subjects diagnosed between 1993 and 2017 at a single general hospital. Outcome measures Date of diagnosis, age, sex, postcode, symptoms, haematinic deficiency, smoking status, serology, family history and autoimmune phenomena. Results The incidence of diagnosed CD rose threefold during the course of the study, with a rising prevalence of positive coeliac serology and positive family history of CD, and a falling prevalence of symptoms and haematinic deficiencies. There was little change in the female predominance, age at diagnosis or high prevalence of other autoimmune conditions over the 25 years, and a paucity throughout of cigarette smokers, particularly heavy smokers. A cohort of patients with seronegative CD was identified who shared many of the characteristics of seropositive CD, but with a significantly older age at diagnosis and a higher prevalence of cigarette smokers. Conclusion There have been major changes in the epidemiology of CD over the last 25 years, of relevance to both our understanding of the aetiopathogenesis of CD and the requirement for service provision. The implications are discussed.
Source: Scopus
Evolving patterns in the presentation of coeliac disease over the last 25 years.
Authors: Stroud, C., Almilaji, O., Nicholas, D., Kirkham, S., Surgenor, S.L., Williams, I. and Snook, J.
Journal: Frontline Gastroenterol
Volume: 11
Issue: 2
Pages: 98-103
ISSN: 2041-4137
DOI: 10.1136/flgastro-2018-101170
Abstract:OBJECTIVE: To document changes in the clinical features of coeliac disease (CD) at presentation over the last 25 years. DESIGN: Observational study. PATIENTS: 802 subjects diagnosed between 1993 and 2017 at a single general hospital. OUTCOME MEASURES: Date of diagnosis, age, sex, postcode, symptoms, haematinic deficiency, smoking status, serology, family history and autoimmune phenomena. RESULTS: The incidence of diagnosed CD rose threefold during the course of the study, with a rising prevalence of positive coeliac serology and positive family history of CD, and a falling prevalence of symptoms and haematinic deficiencies. There was little change in the female predominance, age at diagnosis or high prevalence of other autoimmune conditions over the 25 years, and a paucity throughout of cigarette smokers, particularly heavy smokers. A cohort of patients with seronegative CD was identified who shared many of the characteristics of seropositive CD, but with a significantly older age at diagnosis and a higher prevalence of cigarette smokers. CONCLUSION: There have been major changes in the epidemiology of CD over the last 25 years, of relevance to both our understanding of the aetiopathogenesis of CD and the requirement for service provision. The implications are discussed.
Source: PubMed
Evolving patterns in the presentation of coeliac disease over the last 25 years
Authors: Stroud, C., Almilaji, O., Nicholas, D., Kirkham, S., Surgenor, S.L., Williams, I. and Snook, J.
Journal: FRONTLINE GASTROENTEROLOGY
Volume: 11
Issue: 2
Pages: 98-103
eISSN: 2041-4145
ISSN: 2041-4137
DOI: 10.1136/flgastro-2018-101170
Source: Web of Science (Lite)
Evolving patterns in the presentation of coeliac disease over the last 25 years
Authors: Stroud, C., Almilaji, O., Nicholas, D., Kirkham, S., Surgenor, S., Williams, I. and Snook, J.
Journal: BMJ: Frontline Gastroenterology
Publisher: BMJ
ISSN: 0959-8138
DOI: 10.1136/flgastro-2018-101170
Source: Manual
Evolving patterns in the presentation of coeliac disease over the last 25 years.
Authors: Stroud, C., Almilaji, O., Nicholas, D., Kirkham, S., Surgenor, S.L., Williams, I. and Snook, J.
Journal: Frontline gastroenterology
Volume: 11
Issue: 2
Pages: 98-103
eISSN: 2041-4145
ISSN: 2041-4137
DOI: 10.1136/flgastro-2018-101170
Abstract:Objective
To document changes in the clinical features of coeliac disease (CD) at presentation over the last 25 years.Design
Observational study.Patients
802 subjects diagnosed between 1993 and 2017 at a single general hospital.Outcome measures
Date of diagnosis, age, sex, postcode, symptoms, haematinic deficiency, smoking status, serology, family history and autoimmune phenomena.Results
The incidence of diagnosed CD rose threefold during the course of the study, with a rising prevalence of positive coeliac serology and positive family history of CD, and a falling prevalence of symptoms and haematinic deficiencies. There was little change in the female predominance, age at diagnosis or high prevalence of other autoimmune conditions over the 25 years, and a paucity throughout of cigarette smokers, particularly heavy smokers. A cohort of patients with seronegative CD was identified who shared many of the characteristics of seropositive CD, but with a significantly older age at diagnosis and a higher prevalence of cigarette smokers.Conclusion
There have been major changes in the epidemiology of CD over the last 25 years, of relevance to both our understanding of the aetiopathogenesis of CD and the requirement for service provision. The implications are discussed.Source: Europe PubMed Central