Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss

Authors: Lewis, W.H., Lind, A.E., Sendra, K.M., Onsbring, H., Williams, T.A., Esteban, G.F., Hirt, R.P., Ettema, T.J.G. and Embley, T.M.

Journal: Molecular Biology and Evolution

Volume: 37

Issue: 2

Pages: 524-539

eISSN: 1537-1719

ISSN: 0737-4038

DOI: 10.1093/molbev/msz239

Abstract:

Hydrogenosomes are H2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition, we generated genomic and transcriptomic data sets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes.

http://eprints.bournemouth.ac.uk/32974/

Source: Scopus

Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss.

Authors: Lewis, W.H., Lind, A.E., Sendra, K.M., Onsbring, H., Williams, T.A., Esteban, G.F., Hirt, R.P., Ettema, T.J.G. and Embley, T.M.

Journal: Mol Biol Evol

Volume: 37

Issue: 2

Pages: 524-539

eISSN: 1537-1719

DOI: 10.1093/molbev/msz239

Abstract:

Hydrogenosomes are H2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition, we generated genomic and transcriptomic data sets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes.

http://eprints.bournemouth.ac.uk/32974/

Source: PubMed

Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss

Authors: Lewis, W.H., Lind, A.E., Sendra, K.M., Onsbring, H., Williams, T.A., Esteban, G.F., Hirt, R.P., Ettema, T.J.G. and Embley, T.M.

Journal: MOLECULAR BIOLOGY AND EVOLUTION

Volume: 37

Issue: 2

Pages: 524-539

eISSN: 1537-1719

ISSN: 0737-4038

DOI: 10.1093/molbev/msz239

http://eprints.bournemouth.ac.uk/32974/

Source: Web of Science (Lite)

Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss

Authors: Lewis, W.H., Lind, A.E., Sendra, K.M., Onsbring, H., Williams, T.A., Esteban, G.F., Hirt, R.P., Ettema, T.J.G. and Embley, T.M.

Journal: Molecular Biology and Evolution

Volume: 37

Issue: 2

Pages: 524-539

eISSN: 1537-1719

ISSN: 0737-4038

DOI: 10.1093/molbev/msz239

Abstract:

© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. Hydrogenosomes are H2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition, we generated genomic and transcriptomic data sets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes.

http://eprints.bournemouth.ac.uk/32974/

Source: Manual

Preferred by: Genoveva Esteban

Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss.

Authors: Lewis, W.H., Lind, A.E., Sendra, K.M., Onsbring, H., Williams, T.A., Esteban, G.F., Hirt, R.P., Ettema, T.J.G. and Embley, T.M.

Journal: Molecular biology and evolution

Volume: 37

Issue: 2

Pages: 524-539

eISSN: 1537-1719

ISSN: 0737-4038

DOI: 10.1093/molbev/msz239

Abstract:

Hydrogenosomes are H2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition, we generated genomic and transcriptomic data sets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes.

http://eprints.bournemouth.ac.uk/32974/

Source: Europe PubMed Central

Convergent evolution of hydrogenosomes from mitochondria by gene transfer and loss.

Authors: Lewis, W.H., Lind, A.E., Sendra, K.M., Onsbring, H., Williams, T.A., Esteban, G., Hirt, R.P., Ettema, T.J.G. and Embley, T.M.

Journal: Molecular Biology and Evolution

Volume: 37

Issue: 2

Pages: 524-539

ISSN: 0737-4038

Abstract:

Hydrogenosomes are H2-producing mitochondrial homologues found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition we generated genomic and transcriptomic datasets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes.

http://eprints.bournemouth.ac.uk/32974/

Source: BURO EPrints