The relation of structural integrity and task-related functional connectivity in the aging brain

Authors: Burianová, H., Marstaller, L., Choupan, J., Sepehrband, F., Ziaei, M. and Reutens, D.

Journal: Neurobiology of Aging

Volume: 36

Issue: 10

Pages: 2830-2837

eISSN: 1558-1497

ISSN: 0197-4580

DOI: 10.1016/j.neurobiolaging.2015.07.006

Abstract:

The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.

http://eprints.bournemouth.ac.uk/35327/

Source: Scopus

The relation of structural integrity and task-related functional connectivity in the aging brain.

Authors: Burianová, H., Marstaller, L., Choupan, J., Sepehrband, F., Ziaei, M. and Reutens, D.

Journal: Neurobiol Aging

Volume: 36

Issue: 10

Pages: 2830-2837

eISSN: 1558-1497

DOI: 10.1016/j.neurobiolaging.2015.07.006

Abstract:

The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.

http://eprints.bournemouth.ac.uk/35327/

Source: PubMed

The relation of structural integrity and task-related functional connectivity in the aging brain

Authors: Burianova, H., Marstaller, L., Choupan, J., Sepehrband, F., Ziaei, M. and Reutens, D.

Journal: NEUROBIOLOGY OF AGING

Volume: 36

Issue: 10

Pages: 2830-2837

eISSN: 1558-1497

ISSN: 0197-4580

DOI: 10.1016/j.neurobiolaging.2015.07.006

http://eprints.bournemouth.ac.uk/35327/

Source: Web of Science (Lite)

The relation of structural integrity and task-related functional connectivity in the aging brain.

Authors: Burianová, H., Marstaller, L., Choupan, J., Sepehrband, F., Ziaei, M. and Reutens, D.

Journal: Neurobiology of aging

Volume: 36

Issue: 10

Pages: 2830-2837

eISSN: 1558-1497

ISSN: 0197-4580

DOI: 10.1016/j.neurobiolaging.2015.07.006

Abstract:

The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.

http://eprints.bournemouth.ac.uk/35327/

Source: Europe PubMed Central

The relation of structural integrity and task-related functional connectivity in the aging brain.

Authors: Burianová, H., Marstaller, L., Choupan, J., Sepehrband, F., Ziaei, M. and Reutens, D.

Journal: Neurobiology of Aging

Volume: 36

Issue: 10

Pages: 2830-2837

ISSN: 0197-4580

Abstract:

The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.

http://eprints.bournemouth.ac.uk/35327/

Source: BURO EPrints