Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: Two case studies

Authors: Al-Janabi, S., Nickels, L.A., Sowman, P.F., Burianová, H., Merrett, D.L. and Thompson, W.F.

Journal: Frontiers in Psychology

Volume: 5

Issue: FEB

eISSN: 1664-1078

DOI: 10.3389/fpsyg.2014.00037

Abstract:

The purpose of this study was to investigate whether or not the right hemisphere can be engaged using Melodic Intonation Therapy (MIT) and excitatory repetitive transcranial magnetic stimulation (rTMS) to improve language function in people with aphasia. The two participants in this study (GOE and AMC) have chronic non-fluent aphasia. A functional Magnetic Resonance Imaging (fMRI) task was used to localize the right Broca's homolog area in the inferior frontal gyrus for rTMS coil placement. The treatment protocol included an rTMS phase, which consisted of 3 treatment sessions that used an excitatory stimulation method known as intermittent theta burst stimulation, and a sham-rTMS phase, which consisted of 3 treatment sessions that used a sham coil. Each treatment session was followed by 40 min of MIT. A linguistic battery was administered after each session. Our findings show that one participant, GOE, improved in verbal fluency and the repetition of phrases when treated with MIT in combination with TMS. However, AMC showed no evidence of behavioral benefit from this brief treatment trial. Post-treatment neural activity changes were observed for both participants in the left Broca's area and right Broca's homolog. These case studies indicate that a combination of MIT and rTMS applied to the right Broca's homolog and MIT has the potential to improve speech and language outcomes for at least some people with post-stroke aphasia. © 2014 Al-Janabi, Nickels, Sowman, Burianová, Merrett and Thompson.

http://eprints.bournemouth.ac.uk/35570/

Source: Scopus

Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: two case studies.

Authors: Al-Janabi, S., Nickels, L.A., Sowman, P.F., Burianová, H., Merrett, D.L. and Thompson, W.F.

Journal: Front Psychol

Volume: 5

Pages: 37

ISSN: 1664-1078

DOI: 10.3389/fpsyg.2014.00037

Abstract:

The purpose of this study was to investigate whether or not the right hemisphere can be engaged using Melodic Intonation Therapy (MIT) and excitatory repetitive transcranial magnetic stimulation (rTMS) to improve language function in people with aphasia. The two participants in this study (GOE and AMC) have chronic non-fluent aphasia. A functional Magnetic Resonance Imaging (fMRI) task was used to localize the right Broca's homolog area in the inferior frontal gyrus for rTMS coil placement. The treatment protocol included an rTMS phase, which consisted of 3 treatment sessions that used an excitatory stimulation method known as intermittent theta burst stimulation, and a sham-rTMS phase, which consisted of 3 treatment sessions that used a sham coil. Each treatment session was followed by 40 min of MIT. A linguistic battery was administered after each session. Our findings show that one participant, GOE, improved in verbal fluency and the repetition of phrases when treated with MIT in combination with TMS. However, AMC showed no evidence of behavioral benefit from this brief treatment trial. Post-treatment neural activity changes were observed for both participants in the left Broca's area and right Broca's homolog. These case studies indicate that a combination of MIT and rTMS applied to the right Broca's homolog has the potential to improve speech and language outcomes for at least some people with post-stroke aphasia.

http://eprints.bournemouth.ac.uk/35570/

Source: PubMed

Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: two case studies

Authors: Al-Janabi, S., Nickels, L.A., Sowman, P.F., Burianova, H., Merrett, D.L. and Thompson, W.F.

Journal: FRONTIERS IN PSYCHOLOGY

Volume: 5

ISSN: 1664-1078

DOI: 10.3389/fpsyg.2014.00037

http://eprints.bournemouth.ac.uk/35570/

Source: Web of Science (Lite)

Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: two case studies.

Authors: Al-Janabi, S., Nickels, L.A., Sowman, P.F., Burianová, H., Merrett, D.L. and Thompson, W.F.

Journal: Frontiers in psychology

Volume: 5

Pages: 37

eISSN: 1664-1078

ISSN: 1664-1078

DOI: 10.3389/fpsyg.2014.00037

Abstract:

The purpose of this study was to investigate whether or not the right hemisphere can be engaged using Melodic Intonation Therapy (MIT) and excitatory repetitive transcranial magnetic stimulation (rTMS) to improve language function in people with aphasia. The two participants in this study (GOE and AMC) have chronic non-fluent aphasia. A functional Magnetic Resonance Imaging (fMRI) task was used to localize the right Broca's homolog area in the inferior frontal gyrus for rTMS coil placement. The treatment protocol included an rTMS phase, which consisted of 3 treatment sessions that used an excitatory stimulation method known as intermittent theta burst stimulation, and a sham-rTMS phase, which consisted of 3 treatment sessions that used a sham coil. Each treatment session was followed by 40 min of MIT. A linguistic battery was administered after each session. Our findings show that one participant, GOE, improved in verbal fluency and the repetition of phrases when treated with MIT in combination with TMS. However, AMC showed no evidence of behavioral benefit from this brief treatment trial. Post-treatment neural activity changes were observed for both participants in the left Broca's area and right Broca's homolog. These case studies indicate that a combination of MIT and rTMS applied to the right Broca's homolog has the potential to improve speech and language outcomes for at least some people with post-stroke aphasia.

http://eprints.bournemouth.ac.uk/35570/

Source: Europe PubMed Central

Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: two case studies.

Authors: Al-Janabi, S., Nickels, L.A., Sowman, P.F., Burianová, H., Merrett, D.L. and Thompson, W.F.

Journal: Frontiers in Psychology

Volume: 5

ISSN: 1664-1078

Abstract:

The purpose of this study was to investigate whether or not the right hemisphere can be engaged using Melodic Intonation Therapy (MIT) and excitatory repetitive transcranial magnetic stimulation (rTMS) to improve language function in people with aphasia. The two participants in this study (GOE and AMC) have chronic non-fluent aphasia. A functional Magnetic Resonance Imaging (fMRI) task was used to localize the right Broca's homolog area in the inferior frontal gyrus for rTMS coil placement. The treatment protocol included an rTMS phase, which consisted of 3 treatment sessions that used an excitatory stimulation method known as intermittent theta burst stimulation, and a sham-rTMS phase, which consisted of 3 treatment sessions that used a sham coil. Each treatment session was followed by 40 min of MIT. A linguistic battery was administered after each session. Our findings show that one participant, GOE, improved in verbal fluency and the repetition of phrases when treated with MIT in combination with TMS. However, AMC showed no evidence of behavioral benefit from this brief treatment trial. Post-treatment neural activity changes were observed for both participants in the left Broca's area and right Broca's homolog. These case studies indicate that a combination of MIT and rTMS applied to the right Broca's homolog has the potential to improve speech and language outcomes for at least some people with post-stroke aphasia.

http://eprints.bournemouth.ac.uk/35570/

Source: BURO EPrints