Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease
Authors: Grady, C.L., McIntosh, A.R., Beig, S., Keightley, M.L., Burian, H. and Black, S.E.
Journal: Journal of Neuroscience
Volume: 23
Issue: 3
Pages: 986-993
ISSN: 0270-6474
DOI: 10.1523/jneurosci.23-03-00986.2003
Abstract:Previous experiments have found that individuals with Alzheimer's disease (AD) show increased activity in prefrontal regions compared with healthy age-matched controls during cognitive tasks. This has been interpreted as compensatory reallocation of cognitive resources, but direct evidence for a facilitating effect on performance has been lacking. To address this we measured neural activity during semantic and episodic memory tasks in mildly demented AD patients and healthy elderly controls. Controls recruited a left hemisphere network of regions, including prefrontal and temporal cortices in both the semantic and episodic tasks. Patients engaged a unique network involving bilateral dorsolateral prefrontal and posterior cortices. Critically, activity in this network of regions was correlated with better performance on both the semantic and episodic tasks in the patients. This provides the most direct evidence to date that AD patients can use additional neural resources in prefrontal cortex, presumably those mediating executive functions, to compensate for losses attributable to the degenerative process of the disease.
Source: Scopus
Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease.
Authors: Grady, C.L., McIntosh, A.R., Beig, S., Keightley, M.L., Burian, H. and Black, S.E.
Journal: J Neurosci
Volume: 23
Issue: 3
Pages: 986-993
eISSN: 1529-2401
DOI: 10.1523/JNEUROSCI.23-03-00986.2003
Abstract:Previous experiments have found that individuals with Alzheimer's disease (AD) show increased activity in prefrontal regions compared with healthy age-matched controls during cognitive tasks. This has been interpreted as compensatory reallocation of cognitive resources, but direct evidence for a facilitating effect on performance has been lacking. To address this we measured neural activity during semantic and episodic memory tasks in mildly demented AD patients and healthy elderly controls. Controls recruited a left hemisphere network of regions, including prefrontal and temporal cortices in both the semantic and episodic tasks. Patients engaged a unique network involving bilateral dorsolateral prefrontal and posterior cortices. Critically, activity in this network of regions was correlated with better performance on both the semantic and episodic tasks in the patients. This provides the most direct evidence to date that AD patients can use additional neural resources in prefrontal cortex, presumably those mediating executive functions, to compensate for losses attributable to the degenerative process of the disease.
Source: PubMed
Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease
Authors: Grady, C.L., McIntosh, A.R., Beig, S., Keightley, M.L., Burian, H. and Black, S.E.
Journal: JOURNAL OF NEUROSCIENCE
Volume: 23
Issue: 3
Pages: 986-993
ISSN: 0270-6474
DOI: 10.1523/jneurosci.23-03-00986.2003
Source: Web of Science (Lite)
Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease.
Authors: Grady, C.L., McIntosh, A.R., Beig, S., Keightley, M.L., Burian, H. and Black, S.E.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume: 23
Issue: 3
Pages: 986-993
eISSN: 1529-2401
ISSN: 0270-6474
DOI: 10.1523/jneurosci.23-03-00986.2003
Abstract:Previous experiments have found that individuals with Alzheimer's disease (AD) show increased activity in prefrontal regions compared with healthy age-matched controls during cognitive tasks. This has been interpreted as compensatory reallocation of cognitive resources, but direct evidence for a facilitating effect on performance has been lacking. To address this we measured neural activity during semantic and episodic memory tasks in mildly demented AD patients and healthy elderly controls. Controls recruited a left hemisphere network of regions, including prefrontal and temporal cortices in both the semantic and episodic tasks. Patients engaged a unique network involving bilateral dorsolateral prefrontal and posterior cortices. Critically, activity in this network of regions was correlated with better performance on both the semantic and episodic tasks in the patients. This provides the most direct evidence to date that AD patients can use additional neural resources in prefrontal cortex, presumably those mediating executive functions, to compensate for losses attributable to the degenerative process of the disease.
Source: Europe PubMed Central