Cognitive and Clinical Predictors of Prefrontal Cortical Thickness Change Following First-Episode of Psychosis

Authors: Tronchin, G., Akudjedu, T.N., Kenney, J.P., McInerney, S., Scanlon, C., McFarland, J., McCarthy, P., Cannon, D.M., Hallahan, B. and McDonald, C.

Journal: Psychiatry Research - Neuroimaging

Volume: 302

eISSN: 1872-7506

ISSN: 0925-4927

DOI: 10.1016/j.pscychresns.2020.111100

Abstract:

The association of neuroanatomical progression with cognitive and clinical deterioration after first-episode of psychosis remains uncertain. This longitudinal study aims to assess whether i)impaired executive functioning and emotional intelligence at first presentation are associated with progressive prefrontal and orbitofrontal cortical thinning ii)negative symptom severity is linked to progressive prefrontal cortical thinning. 1.5T MRI images were acquired at baseline and after 3.5 years for 20 individuals with first-episode psychosis and 18 controls. The longitudinal pipeline of Freesurfer was employed to parcellate prefrontal cortex at two time points. Baseline cognitive performance was compared between diagnostic groups using MANCOVA. Partial correlations investigated relationships between cognition and negative symptoms at baseline and cortical thickness change over time. Patients displayed poorer performance than controls at baseline in working memory, reasoning/problem solving and emotional intelligence. In patients, loss of prefrontal and orbitofrontal thickness over time was predicted by impaired working memory and emotional intelligence respectively at baseline. Moreover, exploratory analyses revealed that the worsening of negative symptoms over time was significantly related to prefrontal cortical thinning. Results indicate that specific cognitive deficits at the onset of psychotic illness are markers of progressive neuroanatomical deficits and that worsening of negative symptoms occurs with prefrontal thickness reduction as the illness progresses.

http://eprints.bournemouth.ac.uk/34080/

Source: Scopus

Cognitive and Clinical Predictors of Prefrontal Cortical Thickness Change Following First-Episode of Psychosis.

Authors: Tronchin, G., Akudjedu, T.N., Kenney, J.P., McInerney, S., Scanlon, C., McFarland, J., McCarthy, P., Cannon, D.M., Hallahan, B. and McDonald, C.

Journal: Psychiatry Res Neuroimaging

Volume: 302

Pages: 111100

eISSN: 1872-7506

DOI: 10.1016/j.pscychresns.2020.111100

Abstract:

The association of neuroanatomical progression with cognitive and clinical deterioration after first-episode of psychosis remains uncertain. This longitudinal study aims to assess whether i)impaired executive functioning and emotional intelligence at first presentation are associated with progressive prefrontal and orbitofrontal cortical thinning ii)negative symptom severity is linked to progressive prefrontal cortical thinning. 1.5T MRI images were acquired at baseline and after 3.5 years for 20 individuals with first-episode psychosis and 18 controls. The longitudinal pipeline of Freesurfer was employed to parcellate prefrontal cortex at two time points. Baseline cognitive performance was compared between diagnostic groups using MANCOVA. Partial correlations investigated relationships between cognition and negative symptoms at baseline and cortical thickness change over time. Patients displayed poorer performance than controls at baseline in working memory, reasoning/problem solving and emotional intelligence. In patients, loss of prefrontal and orbitofrontal thickness over time was predicted by impaired working memory and emotional intelligence respectively at baseline. Moreover, exploratory analyses revealed that the worsening of negative symptoms over time was significantly related to prefrontal cortical thinning. Results indicate that specific cognitive deficits at the onset of psychotic illness are markers of progressive neuroanatomical deficits and that worsening of negative symptoms occurs with prefrontal thickness reduction as the illness progresses.

http://eprints.bournemouth.ac.uk/34080/

Source: PubMed

Cognitive and Clinical Predictors of Prefrontal Cortical Thickness Change Following First-Episode of Psychosis

Authors: Tronchin, G., Akudjedu, T.N., Kenney, J.P., McInerney, S., Scanlon, C., McFarland, J., McCarthy, P., Cannon, D.M., Hallahan, B. and McDonald, C.

Journal: PSYCHIATRY RESEARCH-NEUROIMAGING

Volume: 302

eISSN: 1872-7506

ISSN: 0925-4927

DOI: 10.1016/j.pscychresns.2020.111100

http://eprints.bournemouth.ac.uk/34080/

Source: Web of Science (Lite)

Cognitive and Clinical Predictors of Prefrontal Cortical Thickness Change Following First-Episode of Psychosis

Authors: Tronchin, G., Akudjedu, T.N., Kenney, J.P.M., McInerney, S., Scanlon, C., McFarland, J., McCarthy, P., Cannon, D.M., Hallahan, B. and McDonald, C.

Journal: Psychiatry Research: Neuroimaging

Publisher: Elsevier

ISSN: 0925-4927

http://eprints.bournemouth.ac.uk/34080/

Source: Manual

Cognitive and Clinical Predictors of Prefrontal Cortical Thickness Change Following First-Episode of Psychosis.

Authors: Tronchin, G., Akudjedu, T.N., Kenney, J.P., McInerney, S., Scanlon, C., McFarland, J., McCarthy, P., Cannon, D.M., Hallahan, B. and McDonald, C.

Journal: Psychiatry research. Neuroimaging

Volume: 302

Pages: 111100

eISSN: 1872-7506

ISSN: 0925-4927

DOI: 10.1016/j.pscychresns.2020.111100

Abstract:

The association of neuroanatomical progression with cognitive and clinical deterioration after first-episode of psychosis remains uncertain. This longitudinal study aims to assess whether i)impaired executive functioning and emotional intelligence at first presentation are associated with progressive prefrontal and orbitofrontal cortical thinning ii)negative symptom severity is linked to progressive prefrontal cortical thinning. 1.5T MRI images were acquired at baseline and after 3.5 years for 20 individuals with first-episode psychosis and 18 controls. The longitudinal pipeline of Freesurfer was employed to parcellate prefrontal cortex at two time points. Baseline cognitive performance was compared between diagnostic groups using MANCOVA. Partial correlations investigated relationships between cognition and negative symptoms at baseline and cortical thickness change over time. Patients displayed poorer performance than controls at baseline in working memory, reasoning/problem solving and emotional intelligence. In patients, loss of prefrontal and orbitofrontal thickness over time was predicted by impaired working memory and emotional intelligence respectively at baseline. Moreover, exploratory analyses revealed that the worsening of negative symptoms over time was significantly related to prefrontal cortical thinning. Results indicate that specific cognitive deficits at the onset of psychotic illness are markers of progressive neuroanatomical deficits and that worsening of negative symptoms occurs with prefrontal thickness reduction as the illness progresses.

http://eprints.bournemouth.ac.uk/34080/

Source: Europe PubMed Central

Cognitive and Clinical Predictors of Prefrontal Cortical Thickness Change Following First-Episode of Psychosis

Authors: Tronchin, G., Akudjedu, T.N., Kenney, J.P.M., McInerney, S., Scanlon, C., McFarland, J., McCarthy, P., Cannon, D.M., Hallahan, B. and McDonald, C.

Journal: Psychiatry Research: Neuroimaging

Volume: 302

Issue: August

ISSN: 0925-4927

Abstract:

The association of neuroanatomical progression with cognitive and clinical deterioration after first-episode of psychosis remains uncertain. This longitudinal study aims to assess whether i)impaired executive functioning and emotional intelligence at first presentation are associated with progressive prefrontal and orbitofrontal cortical thinning ii)negative symptom severity is linked to progressive prefrontal cortical thinning. 1.5T MRI images were acquired at baseline and after 3.5 years for 20 individuals with first-episode psychosis and 18 controls. The longitudinal pipeline of Freesurfer was employed to parcellate prefrontal cortex at two time points. Baseline cognitive performance was compared between diagnostic groups using MANCOVA. Partial correlations investigated relationships between cognition and negative symptoms at baseline and cortical thickness change over time. Patients displayed poorer performance than controls at baseline in working memory, reasoning/problem solving and emotional intelligence. In patients, loss of prefrontal and orbitofrontal thickness over time was predicted by impaired working memory and emotional intelligence respectively at baseline. Moreover, exploratory analyses revealed that the worsening of negative symptoms over time was significantly related to prefrontal cortical thinning. Results indicate that specific cognitive deficits at the onset of psychotic illness are markers of progressive neuroanatomical deficits and that worsening of negative symptoms occurs with prefrontal thickness reduction as the illness progresses.

http://eprints.bournemouth.ac.uk/34080/

Source: BURO EPrints