Parametric mapping of the hepatic perfusion index with gadolinium-enhanced volumetric MRI
Authors: White, M.J., O'Gorman, R.L., Charles-Edwards, E.M., Kane, P.A., Karani, J.B., Leach, M.O. and Totman, J.J.
Journal: British Journal of Radiology
Volume: 80
Issue: 950
Pages: 113-120
ISSN: 0007-1285
DOI: 10.1259/bjr/36793733
Abstract:The purpose of this study was to adapt the hepatic perfusion index (HPI) methodology previously developed for MRI to derive 3D parametric maps of HPI, and to investigate apparent differences in HPI maps between a group of colorectal cancer patients and controls. To achieve this, a new and simpler approach to HPI calculation which does not require measurements from the aorta or portal vein is introduced, and assessed with large liver regions of interest (ROIs) in patients and controls. Several example HPI maps showing localized variation are then presented. The subject group consisted of 12 patients with known colorectal metastases, and 13 control subjects referred for routine contrast-enhanced spine imaging with no history of neoplastic disease. HPI was evaluated from serial T1 volume acquisitions acquired over the course of a Gd-DTPA bolus injection. Regions of abnormal perfusion were visible on the HPI maps derived for the patient group, manifested as areas of locally increased HPI extending around the visible margins of known metastases evident on the conventional contrast-enhanced images. This method for MR voxel-based parametric mapping of HPI has the potential to demonstrate regional variations in perfusion at the segmental and subsegmental level. © 2007 The British Institute of Radiology.
Source: Scopus
Parametric mapping of the hepatic perfusion index with gadolinium-enhanced volumetric MRI.
Authors: White, M.J., O'Gorman, R.L., Charles-Edwards, E.M., Kane, P.A., Karani, J.B., Leach, M.O. and Totman, J.J.
Journal: Br J Radiol
Volume: 80
Issue: 950
Pages: 113-120
eISSN: 1748-880X
DOI: 10.1259/bjr/36793733
Abstract:The purpose of this study was to adapt the hepatic perfusion index (HPI) methodology previously developed for MRI to derive 3D parametric maps of HPI, and to investigate apparent differences in HPI maps between a group of colorectal cancer patients and controls. To achieve this, a new and simpler approach to HPI calculation which does not require measurements from the aorta or portal vein is introduced, and assessed with large liver regions of interest (ROIs) in patients and controls. Several example HPI maps showing localized variation are then presented. The subject group consisted of 12 patients with known colorectal metastases, and 13 control subjects referred for routine contrast-enhanced spine imaging with no history of neoplastic disease. HPI was evaluated from serial T1 volume acquisitions acquired over the course of a Gd-DTPA bolus injection. Regions of abnormal perfusion were visible on the HPI maps derived for the patient group, manifested as areas of locally increased HPI extending around the visible margins of known metastases evident on the conventional contrast-enhanced images. This method for MR voxel-based parametric mapping of HPI has the potential to demonstrate regional variations in perfusion at the segmental and subsegmental level.
Source: PubMed
Parametric mapping of the hepatic perfusion index with gadolinium-enhanced volumetric MRI
Authors: White, M.J., O’gorman, R.L., Charles-Edwards, E.M., Kane, P.A., Karani, J.B., Leach, M.O. and Totman, J.J.
Journal: The British journal of radiology
Volume: 80
Pages: 113-120
Publisher: British Institute of Radiology
Source: Manual
Parametric mapping of the hepatic perfusion index with gadolinium-enhanced volumetric MRI.
Authors: White, M.J., O'Gorman, R.L., Charles-Edwards, E.M., Kane, P.A., Karani, J.B., Leach, M.O. and Totman, J.J.
Journal: The British journal of radiology
Volume: 80
Issue: 950
Pages: 113-120
eISSN: 1748-880X
ISSN: 0007-1285
DOI: 10.1259/bjr/36793733
Abstract:The purpose of this study was to adapt the hepatic perfusion index (HPI) methodology previously developed for MRI to derive 3D parametric maps of HPI, and to investigate apparent differences in HPI maps between a group of colorectal cancer patients and controls. To achieve this, a new and simpler approach to HPI calculation which does not require measurements from the aorta or portal vein is introduced, and assessed with large liver regions of interest (ROIs) in patients and controls. Several example HPI maps showing localized variation are then presented. The subject group consisted of 12 patients with known colorectal metastases, and 13 control subjects referred for routine contrast-enhanced spine imaging with no history of neoplastic disease. HPI was evaluated from serial T1 volume acquisitions acquired over the course of a Gd-DTPA bolus injection. Regions of abnormal perfusion were visible on the HPI maps derived for the patient group, manifested as areas of locally increased HPI extending around the visible margins of known metastases evident on the conventional contrast-enhanced images. This method for MR voxel-based parametric mapping of HPI has the potential to demonstrate regional variations in perfusion at the segmental and subsegmental level.
Source: Europe PubMed Central