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Beyond ¹⁸F-FDG: Characterization of PET/CT and PET/MR scanners for a comprehensive set of positron emitters of growing application-¹⁸F, ¹¹C, ⁸⁹Zr, ¹²⁴I,⁶⁸Ga, and ⁹⁰Y

Authors: Therese Soderlund, A., Chaal, J., Tjio, G., Totman, J.J., Conti, M. and Townsend, D.W.

Journal: Journal of Nuclear Medicine

Volume: 56

Issue: 8

Pages: 1285-1291

eISSN: 2159-662X

ISSN: 0161-5505

DOI: 10.2967/jnumed.115.156711

Abstract:

This study aimed to investigate image quality for a comprehensive set of isotopes (18F, 11C, 89Zr, 124I, 68Ga, and 90Y) on 2 clinical scanners: a PET/CT scanner and a PET/MR scanner. Methods: Image quality and spatial resolution were tested according to NU 2-2007 of the National Electrical Manufacturers Association. An imagequality phantom was used to measure contrast recovery, residual bias in a cold area, and background variability. Reconstruction methods available on the 2 scanners were compared, including point-spreadfunction correction for both scanners and time of flight for the PET/CT scanner. Spatial resolution was measured using point sources and filtered backprojection reconstruction. Results: With the exception of 90Y, small differences were seen in the hot-sphere contrast recovery of the different isotopes. Cold-sphere contrast recovery was similar across isotopes for all reconstructions, with an improvement seen with time of flight on the PET/CT scanner. The lower-statistic 90Y scans yielded substantially lower contrast recovery than the other isotopes. When isotopes were compared, there was no difference in measured spatial resolution except for PET/MR axial spatial resolution, which was significantly higher for 124I and 68Ga. Conclusion: Overall, both scanners produced good images with 18F, 11C, 89Zr, 124I, 68Ga, and 90Y.

Source: Scopus

Beyond 18F-FDG: Characterization of PET/CT and PET/MR Scanners for a Comprehensive Set of Positron Emitters of Growing Application--18F, 11C, 89Zr, 124I, 68Ga, and 90Y.

Authors: Soderlund, A.T., Chaal, J., Tjio, G., Totman, J.J., Conti, M. and Townsend, D.W.

Journal: J Nucl Med

Volume: 56

Issue: 8

Pages: 1285-1291

eISSN: 1535-5667

DOI: 10.2967/jnumed.115.156711

Abstract:

UNLABELLED: This study aimed to investigate image quality for a comprehensive set of isotopes ((18)F, (11)C, (89)Zr, (124)I, (68)Ga, and (90)Y) on 2 clinical scanners: a PET/CT scanner and a PET/MR scanner. METHODS: Image quality and spatial resolution were tested according to NU 2-2007 of the National Electrical Manufacturers Association. An image-quality phantom was used to measure contrast recovery, residual bias in a cold area, and background variability. Reconstruction methods available on the 2 scanners were compared, including point-spread-function correction for both scanners and time of flight for the PET/CT scanner. Spatial resolution was measured using point sources and filtered backprojection reconstruction. RESULTS: With the exception of (90)Y, small differences were seen in the hot-sphere contrast recovery of the different isotopes. Cold-sphere contrast recovery was similar across isotopes for all reconstructions, with an improvement seen with time of flight on the PET/CT scanner. The lower-statistic (90)Y scans yielded substantially lower contrast recovery than the other isotopes. When isotopes were compared, there was no difference in measured spatial resolution except for PET/MR axial spatial resolution, which was significantly higher for (124)I and (68)Ga. CONCLUSION: Overall, both scanners produced good images with (18)F, (11)C, (89)Zr, (124)I, (68)Ga, and (90)Y.

Source: PubMed

Beyond 18F-FDG: Characterization of PET/CT and PET/MR Scanners for a Comprehensive Set of Positron Emitters of Growing Application--18F, 11C, 89Zr, 124I, 68Ga, and 90Y.

Authors: Soderlund, A.T., Chaal, J., Tjio, G., Totman, J.J., Conti, M. and Townsend, D.W.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Volume: 56

Issue: 8

Pages: 1285-1291

eISSN: 1535-5667

ISSN: 0161-5505

DOI: 10.2967/jnumed.115.156711

Abstract:

Unlabelled

This study aimed to investigate image quality for a comprehensive set of isotopes ((18)F, (11)C, (89)Zr, (124)I, (68)Ga, and (90)Y) on 2 clinical scanners: a PET/CT scanner and a PET/MR scanner.

Methods

Image quality and spatial resolution were tested according to NU 2-2007 of the National Electrical Manufacturers Association. An image-quality phantom was used to measure contrast recovery, residual bias in a cold area, and background variability. Reconstruction methods available on the 2 scanners were compared, including point-spread-function correction for both scanners and time of flight for the PET/CT scanner. Spatial resolution was measured using point sources and filtered backprojection reconstruction.

Results

With the exception of (90)Y, small differences were seen in the hot-sphere contrast recovery of the different isotopes. Cold-sphere contrast recovery was similar across isotopes for all reconstructions, with an improvement seen with time of flight on the PET/CT scanner. The lower-statistic (90)Y scans yielded substantially lower contrast recovery than the other isotopes. When isotopes were compared, there was no difference in measured spatial resolution except for PET/MR axial spatial resolution, which was significantly higher for (124)I and (68)Ga.

Conclusion

Overall, both scanners produced good images with (18)F, (11)C, (89)Zr, (124)I, (68)Ga, and (90)Y.

Source: Europe PubMed Central