Greater male than female variability in regional brain structure across the lifespan
Authors: Wierenga, L.M., Akudjedu, T.N. et al.
Journal: Human Brain Mapping
Volume: 43
Issue: 1
Pages: 470-499
eISSN: 1097-0193
ISSN: 1065-9471
DOI: 10.1002/hbm.25204
Abstract:For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
https://eprints.bournemouth.ac.uk/34689/
Source: Scopus
Greater male than female variability in regional brain structure across the lifespan.
Authors: Wierenga, L.M., Akudjedu, T.N. et al.
Journal: Hum Brain Mapp
Volume: 43
Issue: 1
Pages: 470-499
eISSN: 1097-0193
DOI: 10.1002/hbm.25204
Abstract:For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
https://eprints.bournemouth.ac.uk/34689/
Source: PubMed
Greater male than female variability in regional brain structure across the lifespan
Authors: Wierenga, L.M., Akudjedu, T.N. et al.
Journal: HUMAN BRAIN MAPPING
Volume: 43
Issue: 1
Pages: 470-499
eISSN: 1097-0193
ISSN: 1065-9471
DOI: 10.1002/hbm.25204
https://eprints.bournemouth.ac.uk/34689/
Source: Web of Science (Lite)
Greater male than female variability in regional brain structure across the lifespan
Authors: Wierenga, L.M., Doucet, G.E., Dima, D., Agartz, I., Aghajani, M., Akudjedu, T.N. and ENIGMA Lifespan Working Group
Journal: Human Brain Mapping
Publisher: Wiley-Blackwell
ISSN: 1065-9471
Abstract:For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1‐90 years old (47% females). We observed significant patterns of greater male than female between‐subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene‐environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex‐specific vulnerability to disorders.
https://eprints.bournemouth.ac.uk/34689/
Source: Manual
Greater male than female variability in regional brain structure across the lifespan.
Authors: Wierenga, L.M., Akudjedu, T.N. et al.
Journal: Human brain mapping
Volume: 43
Issue: 1
Pages: 470-499
eISSN: 1097-0193
ISSN: 1065-9471
DOI: 10.1002/hbm.25204
Abstract:For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
https://eprints.bournemouth.ac.uk/34689/
Source: Europe PubMed Central
Greater male than female variability in regional brain structure across the lifespan
Authors: Wierenga, L.M., Akudjedu, T.N. et al.
Journal: Human Brain Mapping
Volume: 43
Issue: 1
Pages: 470-499
ISSN: 1065-9471
Abstract:For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1‐90 years old (47% females). We observed significant patterns of greater male than female between‐subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene‐environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex‐specific vulnerability to disorders.
https://eprints.bournemouth.ac.uk/34689/
Source: BURO EPrints