Titanium dioxide nanoparticle genotoxicity: A review of recent in vivo and in vitro studies
Authors: Wani, M.R. and Shadab, G.G.H.A.
Journal: Toxicology and Industrial Health
Volume: 36
Issue: 7
Pages: 514-530
eISSN: 1477-0393
ISSN: 0748-2337
DOI: 10.1177/0748233720936835
Abstract:Titanium dioxide nanoparticles (TiO2 NPs, size <100 nm) find applications in a wide range of products including food and cosmetics. Studies have found that exposure to TiO2 NPs can cause inflammation, cytotoxicity, genotoxicity and cell apoptosis. In this article, we have reviewed the recent literature on the potential of TiO2 NPs to cause genotoxicity and summarized the results of two standard genotoxicity assays, the comet and micronucleus (MN) assays. Analysis of these peer-reviewed publications shows that the comet assay is the most common genotoxicity test, followed by MN, Ames, and chromosome aberration tests. These assays have reported positive as well as negative results, although there is inconsistency in some results that need to be confirmed further by well-designed experiments. We also discuss the possible mechanisms of TiO2 NP genotoxicity and point out areas that warrant further research.
Source: Scopus
Titanium dioxide nanoparticle genotoxicity: A review of recent in vivo and in vitro studies.
Authors: Wani, M.R. and Shadab, G.
Journal: Toxicol Ind Health
Volume: 36
Issue: 7
Pages: 514-530
eISSN: 1477-0393
DOI: 10.1177/0748233720936835
Abstract:Titanium dioxide nanoparticles (TiO2 NPs, size <100 nm) find applications in a wide range of products including food and cosmetics. Studies have found that exposure to TiO2 NPs can cause inflammation, cytotoxicity, genotoxicity and cell apoptosis. In this article, we have reviewed the recent literature on the potential of TiO2 NPs to cause genotoxicity and summarized the results of two standard genotoxicity assays, the comet and micronucleus (MN) assays. Analysis of these peer-reviewed publications shows that the comet assay is the most common genotoxicity test, followed by MN, Ames, and chromosome aberration tests. These assays have reported positive as well as negative results, although there is inconsistency in some results that need to be confirmed further by well-designed experiments. We also discuss the possible mechanisms of TiO2 NP genotoxicity and point out areas that warrant further research.
Source: PubMed
Titanium dioxide nanoparticle genotoxicity: A review of recent <i>in vivo</i> and <i>in vitro</i> studies.
Authors: Wani, M.R. and Shadab, G.
Journal: Toxicology and industrial health
Volume: 36
Issue: 7
Pages: 514-530
eISSN: 1477-0393
ISSN: 0748-2337
DOI: 10.1177/0748233720936835
Abstract:Titanium dioxide nanoparticles (TiO2 NPs, size <100 nm) find applications in a wide range of products including food and cosmetics. Studies have found that exposure to TiO2 NPs can cause inflammation, cytotoxicity, genotoxicity and cell apoptosis. In this article, we have reviewed the recent literature on the potential of TiO2 NPs to cause genotoxicity and summarized the results of two standard genotoxicity assays, the comet and micronucleus (MN) assays. Analysis of these peer-reviewed publications shows that the comet assay is the most common genotoxicity test, followed by MN, Ames, and chromosome aberration tests. These assays have reported positive as well as negative results, although there is inconsistency in some results that need to be confirmed further by well-designed experiments. We also discuss the possible mechanisms of TiO2 NP genotoxicity and point out areas that warrant further research.
Source: Europe PubMed Central