<sup>18</sup>F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology
Authors: Kalimuddin, S. et al.
Journal: Antiviral Research
Volume: 185
eISSN: 1872-9096
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2020.104991
Abstract:In mouse models of dengue virus (DENV) infection, 18F-FDG PET is able to sensitively detect tissue-specific sites of inflammation and disease activity, as well as track therapeutic response to anti- DENV agents. However, the use of 18F-FDG PET to study the pathogenesis of inflammation and disease activity in DENV infection in humans, has not been clinically validated. Here we report the 18F-FDG PET imaging results of two patients during the febrile phase of acute DENV infection, paired with serial serum viral load, NS1 and proinflammatory cytokine measurements. Our findings demonstrate that 18F-FDG PET is able to sensitively detect and quantify organ-specific inflammation in the lymph nodes and spleen, in classic acute dengue fever. This raises the potential for 18F-FDG PET to be used as a research tool that may provide further insights into disease pathogenesis.
https://eprints.bournemouth.ac.uk/35131/
Source: Scopus
18F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology.
Authors: Kalimuddin, S. et al.
Journal: Antiviral Res
Volume: 185
Pages: 104991
eISSN: 1872-9096
DOI: 10.1016/j.antiviral.2020.104991
Abstract:In mouse models of dengue virus (DENV) infection, 18F-FDG PET is able to sensitively detect tissue-specific sites of inflammation and disease activity, as well as track therapeutic response to anti- DENV agents. However, the use of 18F-FDG PET to study the pathogenesis of inflammation and disease activity in DENV infection in humans, has not been clinically validated. Here we report the 18F-FDG PET imaging results of two patients during the febrile phase of acute DENV infection, paired with serial serum viral load, NS1 and proinflammatory cytokine measurements. Our findings demonstrate that 18F-FDG PET is able to sensitively detect and quantify organ-specific inflammation in the lymph nodes and spleen, in classic acute dengue fever. This raises the potential for 18F-FDG PET to be used as a research tool that may provide further insights into disease pathogenesis.
https://eprints.bournemouth.ac.uk/35131/
Source: PubMed
<SUP>18</SUP>F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology
Authors: Kalimuddin, S. et al.
Journal: ANTIVIRAL RESEARCH
Volume: 185
eISSN: 1872-9096
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2020.104991
https://eprints.bournemouth.ac.uk/35131/
Source: Web of Science (Lite)
<sup>18</sup>F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology.
Authors: Kalimuddin, S. et al.
Journal: Antiviral research
Volume: 185
Pages: 104991
eISSN: 1872-9096
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2020.104991
Abstract:In mouse models of dengue virus (DENV) infection, 18F-FDG PET is able to sensitively detect tissue-specific sites of inflammation and disease activity, as well as track therapeutic response to anti- DENV agents. However, the use of 18F-FDG PET to study the pathogenesis of inflammation and disease activity in DENV infection in humans, has not been clinically validated. Here we report the 18F-FDG PET imaging results of two patients during the febrile phase of acute DENV infection, paired with serial serum viral load, NS1 and proinflammatory cytokine measurements. Our findings demonstrate that 18F-FDG PET is able to sensitively detect and quantify organ-specific inflammation in the lymph nodes and spleen, in classic acute dengue fever. This raises the potential for 18F-FDG PET to be used as a research tool that may provide further insights into disease pathogenesis.
https://eprints.bournemouth.ac.uk/35131/
Source: Europe PubMed Central
18F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology.
Authors: Kalimuddin, S. et al.
Journal: Antiviral Research
Volume: 185
Issue: January
ISSN: 0166-3542
Abstract:In mouse models of dengue virus (DENV) infection, 18F-FDG PET is able to sensitively detect tissue-specific sites of inflammation and disease activity, as well as track therapeutic response to anti- DENV agents. However, the use of 18F-FDG PET to study the pathogenesis of inflammation and disease activity in DENV infection in humans, has not been clinically validated. Here we report the 18F-FDG PET imaging results of two patients during the febrile phase of acute DENV infection, paired with serial serum viral load, NS1 and proinflammatory cytokine measurements. Our findings demonstrate that 18F-FDG PET is able to sensitively detect and quantify organ-specific inflammation in the lymph nodes and spleen, in classic acute dengue fever. This raises the potential for 18F-FDG PET to be used as a research tool that may provide further insights into disease pathogenesis.
https://eprints.bournemouth.ac.uk/35131/
Source: BURO EPrints