Nutritional epigenomics and age-related disease
Authors: Amenyah, S.D., Ward, M., Strain, J.J., McNulty, H., Hughes, C.F., Dollin, C., Walsh, C.P. and Lees-Murdock, D.J.
Journal: Current Developments in Nutrition
Volume: 4
Issue: 7
Pages: 1-16
eISSN: 2475-2991
DOI: 10.1093/CDN/NZAA097
Abstract:Recent advances in epigenetic research have enabled the development of epigenetic clocks, which have greatly enhanced our ability to investigate molecular processes that contribute to aging and age-related disease. These biomarkers offer the potential to measure the effect of environmental exposures linked to dynamic changes in DNA methylation, including nutrients, as factors in age-related disease. They also offer a compelling insight into how imbalances in the supply of nutrients, particularly B-vitamins, or polymorphisms in regulatory enzymes involved in 1-carbon metabolism, the key pathway that supplies methyl groups for epigenetic reactions, may influence epigenetic age and interindividual disease susceptibility. Evidence from recent studies is critically reviewed, focusing on the significant contribution of the epigenetic clock to nutritional epigenomics and its impact on health outcomes and age-related disease. Further longitudinal studies and randomized nutritional interventions are required to advance the field. Curr Dev Nutr 2020;4:nzaa097.
https://eprints.bournemouth.ac.uk/36056/
Source: Scopus
Nutritional Epigenomics and Age-Related Disease.
Authors: Amenyah, S.D., Ward, M., Strain, J.J., McNulty, H., Hughes, C.F., Dollin, C., Walsh, C.P. and Lees-Murdock, D.J.
Journal: Curr Dev Nutr
Volume: 4
Issue: 7
Pages: nzaa097
eISSN: 2475-2991
DOI: 10.1093/cdn/nzaa097
Abstract:Recent advances in epigenetic research have enabled the development of epigenetic clocks, which have greatly enhanced our ability to investigate molecular processes that contribute to aging and age-related disease. These biomarkers offer the potential to measure the effect of environmental exposures linked to dynamic changes in DNA methylation, including nutrients, as factors in age-related disease. They also offer a compelling insight into how imbalances in the supply of nutrients, particularly B-vitamins, or polymorphisms in regulatory enzymes involved in 1-carbon metabolism, the key pathway that supplies methyl groups for epigenetic reactions, may influence epigenetic age and interindividual disease susceptibility. Evidence from recent studies is critically reviewed, focusing on the significant contribution of the epigenetic clock to nutritional epigenomics and its impact on health outcomes and age-related disease. Further longitudinal studies and randomized nutritional interventions are required to advance the field.
https://eprints.bournemouth.ac.uk/36056/
Source: PubMed
Nutritional Epigenomics and Age-Related Disease
Authors: Amenyah, S.D., Ward, M., Strain, J.J., McNulty, H., Hughes, C.F., Dollin, C., Walsh, C.P. and Lees-Murdock, D.J.
Journal: CURRENT DEVELOPMENTS IN NUTRITION
Volume: 4
Issue: 7
ISSN: 2475-2991
DOI: 10.1093/cdn/nzaa097
https://eprints.bournemouth.ac.uk/36056/
Source: Web of Science (Lite)
Nutritional Epigenomics and Age-Related Disease.
Authors: Amenyah, S.D., Ward, M., Strain, J.J., McNulty, H., Hughes, C.F., Dollin, C., Walsh, C.P. and Lees-Murdock, D.J.
Journal: Current developments in nutrition
Volume: 4
Issue: 7
Pages: nzaa097
eISSN: 2475-2991
ISSN: 2475-2991
DOI: 10.1093/cdn/nzaa097
Abstract:Recent advances in epigenetic research have enabled the development of epigenetic clocks, which have greatly enhanced our ability to investigate molecular processes that contribute to aging and age-related disease. These biomarkers offer the potential to measure the effect of environmental exposures linked to dynamic changes in DNA methylation, including nutrients, as factors in age-related disease. They also offer a compelling insight into how imbalances in the supply of nutrients, particularly B-vitamins, or polymorphisms in regulatory enzymes involved in 1-carbon metabolism, the key pathway that supplies methyl groups for epigenetic reactions, may influence epigenetic age and interindividual disease susceptibility. Evidence from recent studies is critically reviewed, focusing on the significant contribution of the epigenetic clock to nutritional epigenomics and its impact on health outcomes and age-related disease. Further longitudinal studies and randomized nutritional interventions are required to advance the field.
https://eprints.bournemouth.ac.uk/36056/
Source: Europe PubMed Central
Nutritional Epigenomics and Age-Related Disease
Authors: Amenyah, S.D., Ward, M., Strain, J.J., McNulty, H., Hughes, C.F., Dollin, C., Walsh, C.P. and Lees-Murdock, D.J.
Journal: Current Developments in Nutrition
Volume: 4
Issue: 7
ISSN: 2475-2991
Abstract:Recent advances in epigenetic research have enabled the development of epigenetic clocks, which have greatly enhanced our ability to investigate molecular processes that contribute to aging and age-related disease. These biomarkers offer the potential to measure the effect of environmental exposures linked to dynamic changes in DNA methylation, including nutrients, as factors in age-related disease. They also offer a compelling insight into how imbalances in the supply of nutrients, particularly B-vitamins, or polymorphisms in regulatory enzymes involved in 1-carbon metabolism, the key pathway that supplies methyl groups for epigenetic reactions, may influence epigenetic age and interindividual disease susceptibility. Evidence from recent studies is critically reviewed, focusing on the significant contribution of the epigenetic clock to nutritional epigenomics and its impact on health outcomes and age-related disease. Further longitudinal studies and randomized nutritional interventions are required to advance the field.
https://eprints.bournemouth.ac.uk/36056/
Source: BURO EPrints