Brain-derived neurotrophic factor: Its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols
Authors: Chaieb, L., Antal, A., Ambrus, G.G. and Paulus, W.
Journal: Neurogenetics
Volume: 15
Issue: 1
Pages: 1-11
eISSN: 1364-6753
ISSN: 1364-6745
DOI: 10.1007/s10048-014-0393-1
Abstract:Val66Met (rs6265) is a gene variation, a single nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene that codes for the protein BDNF. The substitution of Met for Val occurs at position 66 in the pro-region of the BDNF gene and is responsible for altered activity-dependent release and recruitment of BDNF in neurons. This is believed to manifest itself in an altered ability in neuroplasticity induction and an increased predisposition toward a number of neurological disorders. Many studies using neuroplasticity-inducing protocols have investigated the impact of the BDNF polymorphism on cortical modulation and plasticity; however, the results are partly contradictory and dependent on the paradigm used in a given study. The aim of this review is to summarize recent knowledge on the relationship of this BDNF SNP and neuroplasticity. © 2014 Springer-Verlag Berlin Heidelberg.
Source: Scopus
Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols.
Authors: Chaieb, L., Antal, A., Ambrus, G.G. and Paulus, W.
Journal: Neurogenetics
Volume: 15
Issue: 1
Pages: 1-11
eISSN: 1364-6753
DOI: 10.1007/s10048-014-0393-1
Abstract:Val66Met (rs6265) is a gene variation, a single nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene that codes for the protein BDNF. The substitution of Met for Val occurs at position 66 in the pro-region of the BDNF gene and is responsible for altered activity-dependent release and recruitment of BDNF in neurons. This is believed to manifest itself in an altered ability in neuroplasticity induction and an increased predisposition toward a number of neurological disorders. Many studies using neuroplasticity-inducing protocols have investigated the impact of the BDNF polymorphism on cortical modulation and plasticity; however, the results are partly contradictory and dependent on the paradigm used in a given study. The aim of this review is to summarize recent knowledge on the relationship of this BDNF SNP and neuroplasticity.
Source: PubMed
Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols
Authors: Chaieb, L., Antal, A., Ambrus, G.G. and Paulus, W.
Journal: NEUROGENETICS
Volume: 15
Issue: 1
Pages: 1-11
eISSN: 1364-6753
ISSN: 1364-6745
DOI: 10.1007/s10048-014-0393-1
Source: Web of Science (Lite)
Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols.
Authors: Chaieb, L., Antal, A., Ambrus, G.G. and Paulus, W.
Journal: Neurogenetics
Volume: 15
Issue: 1
Pages: 1-11
eISSN: 1364-6753
ISSN: 1364-6745
DOI: 10.1007/s10048-014-0393-1
Abstract:Val66Met (rs6265) is a gene variation, a single nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene that codes for the protein BDNF. The substitution of Met for Val occurs at position 66 in the pro-region of the BDNF gene and is responsible for altered activity-dependent release and recruitment of BDNF in neurons. This is believed to manifest itself in an altered ability in neuroplasticity induction and an increased predisposition toward a number of neurological disorders. Many studies using neuroplasticity-inducing protocols have investigated the impact of the BDNF polymorphism on cortical modulation and plasticity; however, the results are partly contradictory and dependent on the paradigm used in a given study. The aim of this review is to summarize recent knowledge on the relationship of this BDNF SNP and neuroplasticity.
Source: Europe PubMed Central