Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.
Authors: Munné, S., Held, K.R., Magli, C.M., Ata, B., Wells, D., Fragouli, E., Baukloh, V., Fischer, R. and Gianaroli, L.
Journal: Fertil Steril
Volume: 97
Issue: 4
Pages: 935-942
eISSN: 1556-5653
DOI: 10.1016/j.fertnstert.2012.01.106
Abstract:OBJECTIVE: To determine the extent of intra-age and intercycle variations in the frequency of first polar body aneuploidy in two consecutive cycles of oocyte retrieval undertaken by the same patient within 1 year. DESIGN: Retrospective study. SETTING: Fertility centers. PATIENT(S): Infertile couples undergoing IVF. INTERVENTION(S): Patients underwent two consecutive cycles of preimplantation genetic screening through first polar body biopsy within 1 year. MAIN OUTCOME MEASURE(S): Meiosis I aneuploidy. RESULT(S): A total of 226 patients underwent 452 cycles of preimplantation genetic screening. Differences within age groups were wide, with 0-100% of oocytes being chromosomally normal in all age groups. Euploidy rates between centers were significantly different (48% vs. 25%). Intercycle differences for the same patient were also wide (0-100%), but with 68.5% of patients having less than ±2 euploid eggs of difference between cycles. CONCLUSION(S): Although euploidy rate decreased on average with advancing maternal age, the high intra-age and intercenter variation in oocyte chromosome abnormalities emphasize the difficulty in estimating how many euploid oocytes a specific woman will have. This may have repercussions for fertility preservation where a defined number of eggs are currently frozen just based on maternal age.
Source: PubMed
Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes
Authors: Munne, S., Held, K.R., Magli, C.M., Ata, B., Wells, D., Fragouli, E., Baukloh, V., Fischer, R. and Gianaroli, L.
Journal: FERTILITY AND STERILITY
Volume: 97
Issue: 4
Pages: 935-942
eISSN: 1556-5653
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2012.01.106
Source: Web of Science (Lite)
Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.
Authors: Munné, S., Held, K.R., Magli, C.M., Ata, B., Wells, D., Fragouli, E., Baukloh, V., Fischer, R. and Gianaroli, L.
Journal: Fertility and sterility
Volume: 97
Issue: 4
Pages: 935-942
eISSN: 1556-5653
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2012.01.106
Abstract:Objective
To determine the extent of intra-age and intercycle variations in the frequency of first polar body aneuploidy in two consecutive cycles of oocyte retrieval undertaken by the same patient within 1 year.Design
Retrospective study.Setting
Fertility centers.Patient(s)
Infertile couples undergoing IVF.Intervention(s)
Patients underwent two consecutive cycles of preimplantation genetic screening through first polar body biopsy within 1 year.Main outcome measure(s)
Meiosis I aneuploidy.Result(s)
A total of 226 patients underwent 452 cycles of preimplantation genetic screening. Differences within age groups were wide, with 0-100% of oocytes being chromosomally normal in all age groups. Euploidy rates between centers were significantly different (48% vs. 25%). Intercycle differences for the same patient were also wide (0-100%), but with 68.5% of patients having less than ±2 euploid eggs of difference between cycles.Conclusion(s)
Although euploidy rate decreased on average with advancing maternal age, the high intra-age and intercenter variation in oocyte chromosome abnormalities emphasize the difficulty in estimating how many euploid oocytes a specific woman will have. This may have repercussions for fertility preservation where a defined number of eggs are currently frozen just based on maternal age.Source: Europe PubMed Central