Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease

Authors: Kvavilashvili, L., Niedźwieńska, A., Gilbert, S.J. and Markostamou, I.

Journal: Trends in Cognitive Sciences

Volume: 24

Issue: 4

Pages: 285-301

eISSN: 1879-307X

ISSN: 1364-6613

DOI: 10.1016/j.tics.2020.01.005

Abstract:

In the absence of a pharmacological cure, finding the most sensitive early cognitive markers of Alzheimer's disease (AD) is becoming increasingly important. In this article we review evidence showing that brain mechanisms of spontaneous, but stimulus-dependent, cognition overlap with key hubs of the default mode network (DMN) that become compromised by amyloid pathology years before the clinical symptoms of AD. This leads to the formulation of a novel hypothesis which predicts that spontaneous, but stimulus-dependent, conscious retrieval processes, that are generally intact in healthy aging, will be particularly compromised in people at the earliest stages of AD. Initial evidence for this hypothesis is presented across diverse experimental paradigms (e.g., prospective memory, mind-wandering), and new avenues for research in this area are outlined.

https://eprints.bournemouth.ac.uk/39406/

Source: Scopus

Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease.

Authors: Kvavilashvili, L., Niedźwieńska, A., Gilbert, S.J. and Markostamou, I.

Journal: Trends Cogn Sci

Volume: 24

Issue: 4

Pages: 285-301

eISSN: 1879-307X

DOI: 10.1016/j.tics.2020.01.005

Abstract:

In the absence of a pharmacological cure, finding the most sensitive early cognitive markers of Alzheimer's disease (AD) is becoming increasingly important. In this article we review evidence showing that brain mechanisms of spontaneous, but stimulus-dependent, cognition overlap with key hubs of the default mode network (DMN) that become compromised by amyloid pathology years before the clinical symptoms of AD. This leads to the formulation of a novel hypothesis which predicts that spontaneous, but stimulus-dependent, conscious retrieval processes, that are generally intact in healthy aging, will be particularly compromised in people at the earliest stages of AD. Initial evidence for this hypothesis is presented across diverse experimental paradigms (e.g., prospective memory, mind-wandering), and new avenues for research in this area are outlined.

https://eprints.bournemouth.ac.uk/39406/

Source: PubMed

Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease

Authors: Kvavilashvili, L., Niedzwienska, A., Gilbert, S.J. and Markostamou, I.

Journal: TRENDS IN COGNITIVE SCIENCES

Volume: 24

Issue: 4

Pages: 285-301

eISSN: 1879-307X

ISSN: 1364-6613

DOI: 10.1016/j.tics.2020.01.005

https://eprints.bournemouth.ac.uk/39406/

Source: Web of Science (Lite)

Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease.

Authors: Kvavilashvili, L., Niedźwieńska, A., Gilbert, S.J. and Markostamou, I.

Journal: Trends in cognitive sciences

Volume: 24

Issue: 4

Pages: 285-301

eISSN: 1879-307X

ISSN: 1364-6613

DOI: 10.1016/j.tics.2020.01.005

Abstract:

In the absence of a pharmacological cure, finding the most sensitive early cognitive markers of Alzheimer's disease (AD) is becoming increasingly important. In this article we review evidence showing that brain mechanisms of spontaneous, but stimulus-dependent, cognition overlap with key hubs of the default mode network (DMN) that become compromised by amyloid pathology years before the clinical symptoms of AD. This leads to the formulation of a novel hypothesis which predicts that spontaneous, but stimulus-dependent, conscious retrieval processes, that are generally intact in healthy aging, will be particularly compromised in people at the earliest stages of AD. Initial evidence for this hypothesis is presented across diverse experimental paradigms (e.g., prospective memory, mind-wandering), and new avenues for research in this area are outlined.

https://eprints.bournemouth.ac.uk/39406/

Source: Europe PubMed Central

Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease

Authors: Kvavilashvili, L., Niedźwieńska, A., Gilbert, S.J. and Markostamou, I.

Journal: Trends in Cognitive Sciences

Volume: 24

Issue: 4

Pages: 285-301

ISSN: 1364-6613

Abstract:

In the absence of a pharmacological cure, finding the most sensitive early cognitive markers of Alzheimer's disease (AD) is becoming increasingly important. In this article we review evidence showing that brain mechanisms of spontaneous, but stimulus-dependent, cognition overlap with key hubs of the default mode network (DMN) that become compromised by amyloid pathology years before the clinical symptoms of AD. This leads to the formulation of a novel hypothesis which predicts that spontaneous, but stimulus-dependent, conscious retrieval processes, that are generally intact in healthy aging, will be particularly compromised in people at the earliest stages of AD. Initial evidence for this hypothesis is presented across diverse experimental paradigms (e.g., prospective memory, mind-wandering), and new avenues for research in this area are outlined.

https://eprints.bournemouth.ac.uk/39406/

Source: BURO EPrints