Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020-December 2021

Authors: Smallman-Raynor, M.R. et al.

Journal: Epidemiology and Infection

Volume: 150

eISSN: 1469-4409

ISSN: 0950-2688

DOI: 10.1017/S0950268822001285

Abstract:

This paper uses a robust method of spatial epidemiological analysis to assess the spatial growth rate of multiple lineages of SARS-CoV-2 in the local authority areas of England, September 2020-December 2021. Using the genomic surveillance records of the COVID-19 Genomics UK (COG-UK) Consortium, the analysis identifies a substantial (7.6-fold) difference in the average rate of spatial growth of 37 sample lineages, from the slowest (Delta AY.4.3) to the fastest (Omicron BA.1). Spatial growth of the Omicron (B.1.1.529 and BA) variant was found to be 2.81× faster than the Delta (B.1.617.2 and AY) variant and 3.76× faster than the Alpha (B.1.1.7 and Q) variant. In addition to AY.4.2 (a designated variant under investigation, VUI-21OCT-01), three Delta sublineages (AY.43, AY.98 and AY.120) were found to display a statistically faster rate of spatial growth than the parent lineage and would seem to merit further investigation. We suggest that the monitoring of spatial growth rates is a potentially valuable adjunct to outbreak response procedures for emerging SARS-CoV-2 variants in a defined population.

https://eprints.bournemouth.ac.uk/39820/

Source: Scopus

Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020-December 2021.

Authors: Smallman-Raynor, M.R., Cliff, A.D. and COVID-19 Genomics UK (COG-UK) Consortium

Journal: Epidemiol Infect

Volume: 150

Pages: e145

eISSN: 1469-4409

DOI: 10.1017/S0950268822001285

Abstract:

This paper uses a robust method of spatial epidemiological analysis to assess the spatial growth rate of multiple lineages of SARS-CoV-2 in the local authority areas of England, September 2020-December 2021. Using the genomic surveillance records of the COVID-19 Genomics UK (COG-UK) Consortium, the analysis identifies a substantial (7.6-fold) difference in the average rate of spatial growth of 37 sample lineages, from the slowest (Delta AY.4.3) to the fastest (Omicron BA.1). Spatial growth of the Omicron (B.1.1.529 and BA) variant was found to be 2.81× faster than the Delta (B.1.617.2 and AY) variant and 3.76× faster than the Alpha (B.1.1.7 and Q) variant. In addition to AY.4.2 (a designated variant under investigation, VUI-21OCT-01), three Delta sublineages (AY.43, AY.98 and AY.120) were found to display a statistically faster rate of spatial growth than the parent lineage and would seem to merit further investigation. We suggest that the monitoring of spatial growth rates is a potentially valuable adjunct to outbreak response procedures for emerging SARS-CoV-2 variants in a defined population.

https://eprints.bournemouth.ac.uk/39820/

Source: PubMed

Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020-December 2021

Authors: Smallman-Raynor, M.R., Mantzouratou, A. et al.

Journal: Epidemiology and Infection

Volume: 150

DOI: 10.1017/S0950268822001285

https://eprints.bournemouth.ac.uk/39820/

Source: Manual

Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020-December 2021.

Authors: Smallman-Raynor, M.R., Cliff, A.D. and COVID-19 Genomics UK (COG-UK) Consortium

Journal: Epidemiology and infection

Volume: 150

Pages: e145

eISSN: 1469-4409

ISSN: 0950-2688

DOI: 10.1017/s0950268822001285

Abstract:

This paper uses a robust method of spatial epidemiological analysis to assess the spatial growth rate of multiple lineages of SARS-CoV-2 in the local authority areas of England, September 2020-December 2021. Using the genomic surveillance records of the COVID-19 Genomics UK (COG-UK) Consortium, the analysis identifies a substantial (7.6-fold) difference in the average rate of spatial growth of 37 sample lineages, from the slowest (Delta AY.4.3) to the fastest (Omicron BA.1). Spatial growth of the Omicron (B.1.1.529 and BA) variant was found to be 2.81× faster than the Delta (B.1.617.2 and AY) variant and 3.76× faster than the Alpha (B.1.1.7 and Q) variant. In addition to AY.4.2 (a designated variant under investigation, VUI-21OCT-01), three Delta sublineages (AY.43, AY.98 and AY.120) were found to display a statistically faster rate of spatial growth than the parent lineage and would seem to merit further investigation. We suggest that the monitoring of spatial growth rates is a potentially valuable adjunct to outbreak response procedures for emerging SARS-CoV-2 variants in a defined population.

https://eprints.bournemouth.ac.uk/39820/

Source: Europe PubMed Central

Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020-December 2021

Authors: Smallman-Raynor, M.R., Mantzouratou, A. et al.

Journal: Epidemiology and Infection

Volume: 150

ISSN: 0950-2688

Abstract:

This paper uses a robust method of spatial epidemiological analysis to assess the spatial growth rate of multiple lineages of SARS-CoV-2 in the local authority areas of England, September 2020–December 2021. Using the genomic surveillance records of the COVID-19 Genomics UK (COG-UK) Consortium, the analysis identifies a substantial (7.6-fold) difference in the average rate of spatial growth of 37 sample lineages, from the slowest (Delta AY.4.3) to the fastest (Omicron BA.1). Spatial growth of the Omicron (B.1.1.529 and BA) variant was found to be 2.81× faster than the Delta (B.1.617.2 and AY) variant and 3.76× faster than the Alpha (B.1.1.7 and Q) variant. In addition to AY.4.2 (a designated variant under investigation, VUI-21OCT-01), three Delta sublineages (AY.43, AY.98 and AY.120) were found to display a statistically faster rate of spatial growth than the parent lineage and would seem to merit further investigation. We suggest that the monitoring of spatial growth rates is a potentially valuable adjunct to outbreak response procedures for emerging SARS-CoV-2 variants in a defined population.

https://eprints.bournemouth.ac.uk/39820/

Source: BURO EPrints