The Relationship Between Dissociated Measures of Inhibition and Hypnotic and Placebo Analgesia Effects.
Authors: Guestini, A. and Parris, B.A.
Journal: Biopsychosoc Sci Med
Volume: 87
Issue: 7
Pages: 470-482
eISSN: 2998-8756
DOI: 10.1097/PSY.0000000000001405
Abstract:OBJECTIVE: The aim of the present research was to assess the relationship between the executive function of inhibition and hypnotic and placebo analgesia. METHODS: In a fully within-subjects experiment, 54 participants performed the Cold Pressor Task under 3 randomized conditions: (1) hypnotic analgesia; (2) placebo analgesia; and (3) a control condition. Pain threshold and pain tolerance were used as measures of pain perception in each condition. Analgesia was calculated by subtracting the control conditions from the 2 critical conditions (hypnosis and placebo). Following recent work indicating doubly-dissociated forms of inhibition, participants also completed: (1) the Stroop task; (2) the Hayling Sentence Completion Task (HSCT) and a matrix reasoning task, in a fixed order. RESULTS: Analyses revealed that both placebo analgesia (effect sizes rB >0.4) and hypnotic analgesia (effect sizes rB >0.7) suggestions were effective. The results also showed that HSCT performance predicted the magnitude of placebo pain threshold ( t(47) =3.448, p <.001, BF 10 =16.4), but not hypnotic pain threshold ( t(47) =0.537, p >.5, BF 01 =3.483). The results for placebo ( t(47) =3.126, p =.003) and hypnotic ( t(47) =0.295, p >.7) pain tolerance and HSCT performance were insensitive (BF 10 >0.3<3). Neither the Stroop task nor matrix reasoning scores predicted analgesic effects ( t s<1.6, p s>.1; BF 10 <0.3). CONCLUSION: The results highlight the efficacy of suggestion on pain perception and show a relationship between performance on the HSCT and the magnitude of the placebo effect. Limitations and directions for future research are discussed.
Source: PubMed
The Relationship Between Dissociated Measures of Inhibition and Hypnotic and Placebo Analgesia Effects
Authors: Guestini, A. and Parris, B.A.
Journal: BIOPSYCHOSOCIAL SCIENCE AND MEDICINE
Volume: 87
Issue: 7
Pages: 470-482
eISSN: 2998-8756
ISSN: 2998-8748
DOI: 10.1097/PSY.0000000000001405
Source: Web of Science (Lite)
The Relationship Between Dissociated Measures of Inhibition and Hypnotic and Placebo Analgesia Effects.
Authors: Guestini, A. and Parris, B.A.
Journal: Biopsychosocial science and medicine
Volume: 87
Issue: 7
Pages: 470-482
eISSN: 2998-8756
ISSN: 2998-8756
DOI: 10.1097/psy.0000000000001405
Abstract:Objective
The aim of the present research was to assess the relationship between the executive function of inhibition and hypnotic and placebo analgesia.Methods
In a fully within-subjects experiment, 54 participants performed the Cold Pressor Task under 3 randomized conditions: (1) hypnotic analgesia; (2) placebo analgesia; and (3) a control condition. Pain threshold and pain tolerance were used as measures of pain perception in each condition. Analgesia was calculated by subtracting the control conditions from the 2 critical conditions (hypnosis and placebo). Following recent work indicating doubly-dissociated forms of inhibition, participants also completed: (1) the Stroop task; (2) the Hayling Sentence Completion Task (HSCT) and a matrix reasoning task, in a fixed order.Results
Analyses revealed that both placebo analgesia (effect sizes rB >0.4) and hypnotic analgesia (effect sizes rB >0.7) suggestions were effective. The results also showed that HSCT performance predicted the magnitude of placebo pain threshold ( t(47) =3.448, p <.001, BF 10 =16.4), but not hypnotic pain threshold ( t(47) =0.537, p >.5, BF 01 =3.483). The results for placebo ( t(47) =3.126, p =.003) and hypnotic ( t(47) =0.295, p >.7) pain tolerance and HSCT performance were insensitive (BF 10 >0.3<3). Neither the Stroop task nor matrix reasoning scores predicted analgesic effects ( t s<1.6, p s>.1; BF 10 <0.3).Conclusion
The results highlight the efficacy of suggestion on pain perception and show a relationship between performance on the HSCT and the magnitude of the placebo effect. Limitations and directions for future research are discussed.Source: Europe PubMed Central