Effects of multisensory stimulation in people with Huntington's disease: A randomized controlled pilot study

Authors: Leng, T.R., Woodward, M.J., Stokes, M.J., Swan, A.V., Wareing, L.A. and Baker, R.

Journal: Clinical Rehabilitation

Volume: 17

Issue: 1

Pages: 30-41

ISSN: 0269-2155

DOI: 10.1191/0269215503cr582oa

Abstract:

Objective: To investigate whether behavioural, motor and physiological responses of individuals with Huntington's disease (HD) to a controlled multisensory environment (MSE) are effective as a therapeutic (sustained effects) or leisure (immediate effects) activity. Design: Pilot study - a randomized, controlled, two-group design. Setting: Specialist residential unit for people with mid-late stage HD. Subjects: Twelve patients with HD (one subject from each group dropped out during the study after week 8 due to medical complications). Interventions: Patients attended eight, 30-minute sessions over a four-week period, of multisensory stimulation (MSE, treatment group) or relaxation activities (control group). Main outcome measures: Between-group comparisons for changes between assessment sessions for two behavioural assessments: Rehabilitation Evaluation - Hall and Baker (REHAB), Behaviour and Mood Disturbance Scale (BMD); a motor assessment: the dyskinesia section of the St Hans Rating Scale (SHRS); physiological measures: blood pressure, heart rate and respiratory rate. Secondary measures during intervention sessions included behavioural assessment using the Interact. Results: There were no significant differences found between the groups for any main outcome measures made between sessions. The MSE group showed some positive effects within-sessions, with the Interact showing significant between-group differences in immediate effects on mood (p = 0.028). There was also a significantly different change over time for within-session changes in stimulation levels (p = 0.0002) and mood (p = 0.0001) between the groups. No physiological effects were observed in relation to sessions in either group. Two MSE subjects underwent changes in medication during the study period.

Source: Scopus

Effects of multisensory stimulation in people with Huntington's disease: a randomized controlled pilot study.

Authors: Leng, T.R., Woodward, M.J., Stokes, M.J., Swan, A.V., Wareing, L.-A. and Baker, R.

Journal: Clin Rehabil

Volume: 17

Issue: 1

Pages: 30-41

ISSN: 0269-2155

DOI: 10.1191/0269215503cr582oa

Abstract:

OBJECTIVE: To investigate whether behavioural, motor and physiological responses of individuals with Huntington's disease (HD) to a controlled multisensory environment (MSE) are effective as a therapeutic (sustained effects) or leisure (immediate effects) activity. DESIGN: Pilot study--a randomized, controlled, two-group design. SETTING: Specialist residential unit for people with mid-late stage HD. SUBJECTS: Twelve patients with HD (one subject from each group dropped out during the study after week 8 due to medical complications). INTERVENTIONS: Patients attended eight, 30-minute sessions over a four-week period, of multisensory stimulation (MSE, treatment group) or relaxation activities (control group). MAIN OUTCOME MEASURES: Between-group comparisons for changes between assessment sessions for two behavioural assessments: Rehabilitation Evaluation--Hall and Baker (REHAB), Behaviour and Mood Disturbance Scale (BMD); a motor assessment: the dyskinesia section of the St Hans Rating Scale (SHRS); physiological measures: blood pressure, heart rate and respiratory rate. Secondary measures during intervention sessions included behavioural assessment using the Interact. RESULTS: There were no significant differences found between the groups for any main outcome measures made between sessions. The MSE group showed some positive effects within-sessions, with the Interact showing significant between-group differences in immediate effects on mood (p = 0.028). There was also a significantly different change over time for within-session changes in stimulation levels (p = 0.0002) and mood (p = 0.0001) between the groups. No physiological effects were observed in relation to sessions in either group. Two MSE subjects underwent changes in medication during the study period. CONCLUSIONS: There was no therapeutic effect of MSEs over the four-week study period. MSEs appear to be more effective thanconventional relaxation techniques as a leisure activity.

Source: PubMed

Effects of multisensory stimulation in people with Huntington's disease: a randomised controlled pilot study

Authors: Leng, T.R., Stokes, M.J., Woodward, K.J., Swan, A.V., Wareing, L.-A. and Baker, R.

Journal: Clinical Rehabilitation

Volume: 17

Pages: 30-41

ISSN: 0269-2155

DOI: 10.1191/0269215503cr582oa

Abstract:

Objective: To investigate whether behavioural, motor and physiological responses of individuals with Huntington’s disease (HD) to a controlled multisensory environment (MSE) are effective as a therapeutic (sustained effects) or leisure (immediate effects) activity.

Design: Pilot study – a randomized, controlled, two-group design.

Setting: Specialist residential unit for people with mid-late stage HD.

Subjects: Twelve patients with HD (one subject from each group dropped out during the study after week 8 due to medical complications).

Interventions: Patients attended eight, 30-minute sessions over a four-week period, of multisensory stimulation (MSE, treatment group) or relaxation activities (control group).

Main outcome measures: Between-group comparisons for changes between assessment sessions for two behavioural assessments: Rehabilitation Evaluation – Hall and Baker (REHAB), Behaviour and Mood Disturbance Scale (BMD); a motor assessment: the dyskinesia section of the St Hans Rating Scale (SHRS); physiological measures: blood pressure, heart rate and respiratory rate. Secondary measures during intervention sessions included behavioural assessment using the Interact.

Results: There were no signiŽcant differences found between the groups for any main outcome measures made between sessions. The MSE group showed some positive effects within-sessions, with the Interact showing significant between-group differences in immediate effects on mood (p = 0.028). There was also a significantly different change over time for within-session changes in stimulation levels (p = 0.0002) and mood (p = 0.0001) between the groups. No physiological effects were observed in relation to sessions in either group. Two MSE subjects underwent changes in medication during the study period.

Conclusions: There was no therapeutic effect of MSEs over the four-week study period. MSEs appear to bemore effective than conventional relaxation techniques as a leisure activity.

http://cre.sagepub.com/cgi/content/abstract/17/1/30

Source: Manual

Preferred by: Roger Baker

Effects of multisensory stimulation in people with Huntington's disease: a randomized controlled pilot study.

Authors: Leng, T.R., Woodward, M.J., Stokes, M.J., Swan, A.V., Wareing, L.-A. and Baker, R.

Journal: Clinical rehabilitation

Volume: 17

Issue: 1

Pages: 30-41

eISSN: 1477-0873

ISSN: 0269-2155

DOI: 10.1191/0269215503cr582oa

Abstract:

Objective

To investigate whether behavioural, motor and physiological responses of individuals with Huntington's disease (HD) to a controlled multisensory environment (MSE) are effective as a therapeutic (sustained effects) or leisure (immediate effects) activity.

Design

Pilot study--a randomized, controlled, two-group design.

Setting

Specialist residential unit for people with mid-late stage HD.

Subjects

Twelve patients with HD (one subject from each group dropped out during the study after week 8 due to medical complications).

Interventions

Patients attended eight, 30-minute sessions over a four-week period, of multisensory stimulation (MSE, treatment group) or relaxation activities (control group).

Main outcome measures

Between-group comparisons for changes between assessment sessions for two behavioural assessments: Rehabilitation Evaluation--Hall and Baker (REHAB), Behaviour and Mood Disturbance Scale (BMD); a motor assessment: the dyskinesia section of the St Hans Rating Scale (SHRS); physiological measures: blood pressure, heart rate and respiratory rate. Secondary measures during intervention sessions included behavioural assessment using the Interact.

Results

There were no significant differences found between the groups for any main outcome measures made between sessions. The MSE group showed some positive effects within-sessions, with the Interact showing significant between-group differences in immediate effects on mood (p = 0.028). There was also a significantly different change over time for within-session changes in stimulation levels (p = 0.0002) and mood (p = 0.0001) between the groups. No physiological effects were observed in relation to sessions in either group. Two MSE subjects underwent changes in medication during the study period.

Conclusions

There was no therapeutic effect of MSEs over the four-week study period. MSEs appear to be more effective thanconventional relaxation techniques as a leisure activity.

Source: Europe PubMed Central