Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes

Authors: Watson, J.M., Jenkins, E.J.E., Hamilton, P., Lunt, M.J. and Kerr, D.

Journal: Diabetes Care

Volume: 23

Issue: 4

Pages: 455-459

ISSN: 0149-5992

DOI: 10.2337/diacare.23.4.455

Abstract:

OBJECTIVE - To examine the influence of caffeine on the frequency and perception of hypoglycemia in 'free-living' patients with type 1 diabetes. RESEARCH DESIGN AND METHODS - A total of 34 patients with type i diabetes were recruited for a prospective randomized placebo-controlled double-blind study after a lead-in phase and while adhering to a low-caffeine diet, subjects were randomized to capsules containing either 200 mg caffeine or matched placebo with crossover at 3 months. Hypoglycemic episodes were monitored throughout with capillary blood glucose readings and a symptom questionnaire. During the study, measurements of blood pressure, middle cerebral artery blood velocity (a surrogate measure of cerebral blood flow), cognitive function (via a four-choice reaction time test), HbA(1c) levels, and lipid profiles were taken at the beginning and end of each phase. RESULTS - Throughout the study, no changes were evident regarding glycemic control or lipid profile. The number of symptomatic episodes was greater with caffeine (1.3 vs. 0.9 episodes/week; P < 0.03) and was associated with more intense warning symptoms (29 vs. 26 total symptom score; P < 0.05). For women, caffeine ingestion caused a modest pressor response (115 vs. 110 mmHg; P < 0.01). Four-choice reaction time improved slightly with caffeine supplementation (P<0.05). CONCLUSIONS - Ingestion of modest amounts of caffeine enhances the intensity of hypoglycemia warning symptoms in patients with type 1 diabetes without altering the prevailing standard of glycemic control or increasing the incidence of severe hypoglycemic episodes.

Source: Scopus

Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes.

Authors: Watson, J.M., Jenkins, E.J., Hamilton, P., Lunt, M.J. and Kerr, D.

Journal: Diabetes Care

Volume: 23

Issue: 4

Pages: 455-459

ISSN: 0149-5992

DOI: 10.2337/diacare.23.4.455

Abstract:

OBJECTIVE: To examine the influence of caffeine on the frequency and perception of hypoglycemia in "free-living" patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: A total of 34 patients with type 1 diabetes were recruited for a prospective randomized placebo-controlled double-blind study. After a lead-in phase and while adhering to a low-caffeine diet, subjects were randomized to capsules containing either 200 mg caffeine or matched placebo with crossover at 3 months. Hypoglycemic episodes were monitored throughout with capillary blood glucose readings and a symptom questionnaire. During the study, measurements of blood pressure, middle cerebral artery blood velocity (a surrogate measure of cerebral blood flow), cognitive function (via a four-choice reaction time test), HbAlc levels, and lipid profiles were taken at the beginning and end of each phase. RESULTS: Throughout the study, no changes were evident regarding glycemic control or lipid profile. The number of symptomatic episodes was greater with caffeine (1.3 vs. 0.9 episodes/week; P < 0.03) and was associated with more intense warning symptoms (29 vs. 26 total symptom score; P < 0.05). For women, caffeine ingestion caused a modest pressor response (115 vs. 110 mmHg; P < 0.01). Four-choice reaction time improved slightly with caffeine supplementation (P < 0.05). CONCLUSIONS: Ingestion of modest amounts of caffeine enhances the intensity of hypoglycemia warning symptoms in patients with type 1 diabetes without altering the prevailing standard of glycemic control or increasing the incidence of severe hypoglycemic episodes.

Source: PubMed

Influence of caffeine on the frequency and perception at hypoglycemia in free-living patients with type 1 diabetes

Authors: Watson, J.M., Jenkins, E.J.E., Hamilton, P., Lunt, M.J. and Kerr, D.

Journal: DIABETES CARE

Volume: 23

Issue: 4

Pages: 455-459

eISSN: 1935-5548

ISSN: 0149-5992

DOI: 10.2337/diacare.23.4.455

Source: Web of Science (Lite)

Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes

Authors: Watson, J.M., Jenkins, E.J., Hamilton, P., Lunt, M.J. and Kerr, D.

Journal: Diabetes Care

Volume: 23

Pages: 455-459

ISSN: 0149-5992

Abstract:

OBJECTIVE: To examine the influence of caffeine on the frequency and perception of hypoglycemia in "free-living" patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: A total of 34 patients with type 1 diabetes were recruited for a prospective randomized placebo-controlled double-blind study. After a lead-in phase and while adhering to a low-caffeine diet, subjects were randomized to capsules containing either 200 mg caffeine or matched placebo with crossover at 3 months. Hypoglycemic episodes were monitored throughout with capillary blood glucose readings and a symptom questionnaire. During the study, measurements of blood pressure, middle cerebral artery blood velocity (a surrogate measure of cerebral blood flow), cognitive function (via a four-choice reaction time test), HbAlc levels, and lipid profiles were taken at the beginning and end of each phase. RESULTS: Throughout the study, no changes were evident regarding glycemic control or lipid profile. The number of symptomatic episodes was greater with caffeine (1.3 vs. 0.9 episodes/week; P < 0.03) and was associated with more intense warning symptoms (29 vs. 26 total symptom score; P < 0.05). For women, caffeine ingestion caused a modest pressor response (115 vs. 110 mmHg; P < 0.01). Four-choice reaction time improved slightly with caffeine supplementation (P < 0.05). CONCLUSIONS: Ingestion of modest amounts of caffeine enhances the intensity of hypoglycemia warning symptoms in patients with type 1 diabetes without altering the prevailing standard of glycemic control or increasing the incidence of severe hypoglycemic episodes.

http://care.diabetesjournals.org/cgi/content/abstract/23/4/455

Source: Manual

Preferred by: David Kerr

Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes.

Authors: Watson, J.M., Jenkins, E.J., Hamilton, P., Lunt, M.J. and Kerr, D.

Journal: Diabetes care

Volume: 23

Issue: 4

Pages: 455-459

eISSN: 1935-5548

ISSN: 0149-5992

DOI: 10.2337/diacare.23.4.455

Abstract:

Objective

To examine the influence of caffeine on the frequency and perception of hypoglycemia in "free-living" patients with type 1 diabetes.

Research design and methods

A total of 34 patients with type 1 diabetes were recruited for a prospective randomized placebo-controlled double-blind study. After a lead-in phase and while adhering to a low-caffeine diet, subjects were randomized to capsules containing either 200 mg caffeine or matched placebo with crossover at 3 months. Hypoglycemic episodes were monitored throughout with capillary blood glucose readings and a symptom questionnaire. During the study, measurements of blood pressure, middle cerebral artery blood velocity (a surrogate measure of cerebral blood flow), cognitive function (via a four-choice reaction time test), HbAlc levels, and lipid profiles were taken at the beginning and end of each phase.

Results

Throughout the study, no changes were evident regarding glycemic control or lipid profile. The number of symptomatic episodes was greater with caffeine (1.3 vs. 0.9 episodes/week; P < 0.03) and was associated with more intense warning symptoms (29 vs. 26 total symptom score; P < 0.05). For women, caffeine ingestion caused a modest pressor response (115 vs. 110 mmHg; P < 0.01). Four-choice reaction time improved slightly with caffeine supplementation (P < 0.05).

Conclusions

Ingestion of modest amounts of caffeine enhances the intensity of hypoglycemia warning symptoms in patients with type 1 diabetes without altering the prevailing standard of glycemic control or increasing the incidence of severe hypoglycemic episodes.

Source: Europe PubMed Central