Glucocorticoid epidural for sciatica: Metabolic and endocrine sequelae
Authors: Ward, A., Watson, J., Wood, P., Dunne, C. and Kerr, D.
Journal: Rheumatology
Volume: 41
Issue: 1
Pages: 68-71
ISSN: 1462-0324
DOI: 10.1093/rheumatology/41.1.68
Abstract:Objective. The study was designed to investigate the effect of epidural administration of glucocorticoid on insulin sensitivity. Methods. Ten healthy individuals with sciatica underwent a short insulin tolerance test before and twice following (at 24 h and 1 week) a caudal epidural containing 80 mg triamcinolone. Fasting glucose, insulin and cortisol concentrations were also measured. Results. The rate of glucose disappearance after insulin administration (kITT) fell from 3.6%/min before the epidural to 1.9%/min 24 h afterwards (P = 0.001) and returned to pretreatment values by 1 week. Significantly raised fasting insulin and glucose levels also reflected impaired insulin sensitivity immediately after the epidural. Morning cortisol levels were suppressed after the epidural (49 nmol/l at 24 h and 95 nmol/l at 1 week vs 352 nmol/l at baseline; P < 0.01). Conclusions. Epidural administration of glucocorticoid results in potent suppression of insulin action and this should be taken into account when patients with diabetes require treatment for sciatica.
Source: Scopus
Glucocorticoid epidural for sciatica: metabolic and endocrine sequelae.
Authors: Ward, A., Watson, J., Wood, P., Dunne, C. and Kerr, D.
Journal: Rheumatology (Oxford)
Volume: 41
Issue: 1
Pages: 68-71
ISSN: 1462-0324
DOI: 10.1093/rheumatology/41.1.68
Abstract:OBJECTIVE: The study was designed to investigate the effect of epidural administration of glucocorticoid on insulin sensitivity. METHODS: Ten healthy individuals with sciatica underwent a short insulin tolerance test before and twice following (at 24 h and 1 week) a caudal epidural containing 80 mg triamcinolone. Fasting glucose, insulin and cortisol concentrations were also measured. RESULTS: The rate of glucose disappearance after insulin administration (k(ITT)) fell from 3.6%/min before the epidural to 1.9%/min 24 h afterwards (P=0.001) and returned to pretreatment values by 1 week. Significantly raised fasting insulin and glucose levels also reflected impaired insulin sensitivity immediately after the epidural. Morning cortisol levels were suppressed after the epidural (49 nmol/l at 24 h and 95 nmol/l at 1 week vs 352 nmol/l at baseline; P<0.01). CONCLUSIONS: Epidural administration of glucocorticoid results in potent suppression of insulin action and this should be taken into account when patients with diabetes require treatment for sciatica.
Source: PubMed
Glucocorticoid epidural for sciatica: metabolic and endocrine sequelae
Authors: Ward, A., Watson, J., Wood, P., Dunne, C. and Kerr, D.
Journal: RHEUMATOLOGY
Volume: 41
Issue: 1
Pages: 68-71
ISSN: 1462-0324
DOI: 10.1093/rheumatology/41.1.68
Source: Web of Science (Lite)
Glucocorticoid epidural for sciatica: metabolic and endocrine sequelae
Authors: Ward, A., Watson, J.M., Wood, P., Dunne, C. and Kerr, D.
Journal: Rheumatology
Volume: 41
Pages: 68-71
ISSN: 1462-0324
Abstract:Objective. The study was designed to investigate the effect of epidural administration of glucocorticoid on insulin sensitivity.
Methods. Ten healthy individuals with sciatica underwent a short insulin tolerance test before and twice following (at 24 h and 1 week) a caudal epidural containing 80 mg triamcinolone. Fasting glucose, insulin and cortisol concentrations were also measured.
Results. The rate of glucose disappearance after insulin administration (kITT) fell from 3.6%/min before the epidural to 1.9%/min 24 h afterwards (P=0.001) and returned to pretreatment values by 1 week. Significantly raised fasting insulin and glucose levels also reflected impaired insulin sensitivity immediately after the epidural. Morning cortisol levels were suppressed after the epidural (49 nmol/l at 24 h and 95 nmol/l at 1 week vs 352 nmol/l at baseline; P<0.01).
Conclusions. Epidural administration of glucocorticoid results in potent suppression of insulin action and this should be taken into account when patients with diabetes require treatment for sciatica.
KEY WORDS: Glucocorticoid, Insulin sensitivity, Epidural, Adrenal suppression, Sciatica.
Source: Manual
Preferred by: David Kerr
Glucocorticoid epidural for sciatica: metabolic and endocrine sequelae.
Authors: Ward, A., Watson, J., Wood, P., Dunne, C. and Kerr, D.
Journal: Rheumatology (Oxford, England)
Volume: 41
Issue: 1
Pages: 68-71
eISSN: 1462-0332
ISSN: 1462-0324
DOI: 10.1093/rheumatology/41.1.68
Abstract:Objective
The study was designed to investigate the effect of epidural administration of glucocorticoid on insulin sensitivity.Methods
Ten healthy individuals with sciatica underwent a short insulin tolerance test before and twice following (at 24 h and 1 week) a caudal epidural containing 80 mg triamcinolone. Fasting glucose, insulin and cortisol concentrations were also measured.Results
The rate of glucose disappearance after insulin administration (k(ITT)) fell from 3.6%/min before the epidural to 1.9%/min 24 h afterwards (P=0.001) and returned to pretreatment values by 1 week. Significantly raised fasting insulin and glucose levels also reflected impaired insulin sensitivity immediately after the epidural. Morning cortisol levels were suppressed after the epidural (49 nmol/l at 24 h and 95 nmol/l at 1 week vs 352 nmol/l at baseline; P<0.01).Conclusions
Epidural administration of glucocorticoid results in potent suppression of insulin action and this should be taken into account when patients with diabetes require treatment for sciatica.Source: Europe PubMed Central