The effect of alcohol on blood glucose in Type 1 diabetes - Metabolic modelling and integration in a decision support system
Authors: Plougmann, S., Hejlesen, O., Turner, B., Kerr, D. and Cavan, D.
Journal: International Journal of Medical Informatics
Volume: 70
Issue: 2-3
Pages: 337-344
ISSN: 1386-5056
DOI: 10.1016/S1386-5056(03)00038-8
Abstract:Introduction: We have recently shown, in studies with patients with Type 1 (insulin dependent) diabetes, that alcohol intake at 21:00 h significantly reduced blood glucose values after 10-12 h, compared with control studies with no alcohol. Hypothesis: We hypothesised that this was due to the following effects of alcohol: (1) alcohol metabolism increases NADH, leading to a reduction in hepatic gluconeogenesis; (2) increased glycogen phosphorylase activity depletes hepatic glycogen stores; (3) after the alcohol is metabolised, hepatic insulin sensitivity is increased, leading to the restoration of glycogen stores and reduction in blood glucose levels; and (4) consequently, after several hours, glycogen stores and insulin sensitivity return to normal. Results: A model describing these changes (DiasNet-Alcohol) was implemented into the DiasNet model of human glucose metabolism. Our study suggests that the DiasNet-Alcohol model gives a reasonable approximation of these effects of alcohol on blood glucose concentration observed in our study and supports our hypothesis for the mechanism behind these effects in Type 1 diabetes. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
Source: Scopus
The effect of alcohol on blood glucose in Type 1 diabetes--metabolic modelling and integration in a decision support system.
Authors: Plougmann, S., Hejlesen, O., Turner, B., Kerr, D. and Cavan, D.
Journal: Int J Med Inform
Volume: 70
Issue: 2-3
Pages: 337-344
ISSN: 1386-5056
DOI: 10.1016/s1386-5056(03)00038-8
Abstract:INTRODUCTION: We have recently shown, in studies with patients with Type 1 (insulin dependent) diabetes, that alcohol intake at 21:00 h significantly reduced blood glucose values after 10-12 h, compared with control studies with no alcohol. HYPOTHESIS: We hypothesised that this was due to the following effects of alcohol: (1) alcohol metabolism increases NADH, leading to a reduction in hepatic gluconeogenesis; (2) increased glycogen phosphorylase activity depletes hepatic glycogen stores; (3) after the alcohol is metabolised, hepatic insulin sensitivity is increased, leading to the restoration of glycogen stores and reduction in blood glucose levels; and (4) consequently, after several hours, glycogen stores and insulin sensitivity return to normal. RESULTS: A model describing these changes (DiasNet-Alcohol) was implemented into the DiasNet model of human glucose metabolism. Our study suggests that the DiasNet-Alcohol model gives a reasonable approximation of these effects of alcohol on blood glucose concentration observed in our study and supports our hypothesis for the mechanism behind these effects in Type 1 diabetes.
Source: PubMed
The effect of alcohol on blood glucose in Type 1 diabetes - metabolic modelling and integration in a decision support system
Authors: Plougmann, S., Hejlesen, O., Turner, B., Kerr, D. and Cavan, D.
Journal: INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
Volume: 70
Issue: 2-3
Pages: 337-344
ISSN: 1386-5056
DOI: 10.1016/S1386-5056(03)00038-8
Source: Web of Science (Lite)
The effect of alcohol on blood glucose in Type 1 diabetes—metabolic modelling and integration in a decision support system
Authors: Plougmann, S., Hejlesen, O.K., Turner, B., Kerr, D. and Cavan, D.A.
Journal: International Journal of Medical Informatics
Volume: 70
Pages: 337-344
ISSN: 1386-5056
DOI: 10.1016/S1386-5056(03)00038-8
Abstract:Introduction: We have recently shown, in studies with patients with Type 1 (insulin dependent) diabetes, that alcohol intake at 21:00 h significantly reduced blood glucose values after 10–12 h, compared with control studies with no alcohol. Hypothesis: We hypothesised that this was due to the following effects of alcohol: (1) alcohol metabolism increases NADH, leading to a reduction in hepatic gluconeogenesis; (2) increased glycogen phosphorylase activity depletes hepatic glycogen stores; (3) after the alcohol is metabolised, hepatic insulin sensitivity is increased, leading to the restoration of glycogen stores and reduction in blood glucose levels; and (4) consequently, after several hours, glycogen stores and insulin sensitivity return to normal. Results: A model describing these changes (DiasNet-Alcohol) was implemented into the DiasNet model of human glucose metabolism. Our study suggests that the DiasNet-Alcohol model gives a reasonable approximation of these effects of alcohol on blood glucose concentration observed in our study and supports our hypothesis for the mechanism behind these effects in Type 1 diabetes.
Source: Manual
Preferred by: David Kerr
The effect of alcohol on blood glucose in Type 1 diabetes - metabolic modelling and integration in a decision support system.
Authors: Plougmann, S., Hejlesen, O.K., Turner, B., Kerr, D. and Cavan, D.A.
Journal: Int. J. Medical Informatics
Volume: 70
Pages: 337-344
DOI: 10.1016/S1386-5056(03)00038-8
Source: DBLP
The effect of alcohol on blood glucose in Type 1 diabetes--metabolic modelling and integration in a decision support system.
Authors: Plougmann, S., Hejlesen, O., Turner, B., Kerr, D. and Cavan, D.
Journal: International journal of medical informatics
Volume: 70
Issue: 2-3
Pages: 337-344
eISSN: 1872-8243
ISSN: 1386-5056
DOI: 10.1016/s1386-5056(03)00038-8
Abstract:Introduction
We have recently shown, in studies with patients with Type 1 (insulin dependent) diabetes, that alcohol intake at 21:00 h significantly reduced blood glucose values after 10-12 h, compared with control studies with no alcohol.Hypothesis
We hypothesised that this was due to the following effects of alcohol: (1) alcohol metabolism increases NADH, leading to a reduction in hepatic gluconeogenesis; (2) increased glycogen phosphorylase activity depletes hepatic glycogen stores; (3) after the alcohol is metabolised, hepatic insulin sensitivity is increased, leading to the restoration of glycogen stores and reduction in blood glucose levels; and (4) consequently, after several hours, glycogen stores and insulin sensitivity return to normal.Results
A model describing these changes (DiasNet-Alcohol) was implemented into the DiasNet model of human glucose metabolism. Our study suggests that the DiasNet-Alcohol model gives a reasonable approximation of these effects of alcohol on blood glucose concentration observed in our study and supports our hypothesis for the mechanism behind these effects in Type 1 diabetes.Source: Europe PubMed Central