Influence of acute alcohol ingestion on the hormonal responses to modest hypoglycaemia in patients with Type 1 diabetes
Authors: Kerr, D., Cheyne, E., Thomas, P. and Sherwin, R.
Journal: Diabetic Medicine
Volume: 24
Issue: 3
Pages: 312-316
eISSN: 1464-5491
ISSN: 0742-3071
DOI: 10.1111/j.1464-5491.2006.02054.x
Abstract:Aims: To determine whether mild alcohol intoxication (45-50 mg/dl) influences counterregulatory hormone responses to moderate hypoglycaemia (2.8 mmol/l) in patients with Type 1 diabetes. Methods: Seventeen subjects (14 male, age range 21-46 years) with Type 1 diabetes underwent four hyperinsulinaemic glucose clamps: euglycaemia with placebo; euglycaemia with alcohol (0.4 g/kg); hypoglycaemia (2.8 mmol/l for 65 min) with placebo; and hypoglycaemia (2.8 mmol/l for 65 min) with alcohol (0.4 g/kg). Arterialized venous blood samples were taken for measurement of insulin and counterregulatory hormones. Results: During hypoglycaemia, peak growth hormone concentrations were significantly lower after alcohol compared with placebo (14.3 ± 2.9 vs. 25.9 ± 3.4 μg/l, P < 0.001) associated with reduced insulin sensitivity in both hypoglycaemia and euglycaemia studies. Conclusions: We found an attenuated growth hormone response to hypoglycaemia associated with mild alcohol intoxication. Although this may potentially contribute to impaired recovery of glucose after hypoglycaemia in patients with Type 1 diabetes, it appears to be offset by a reduction in insulin action. © 2007 The Authors.
Source: Scopus
Influence of acute alcohol ingestion on the hormonal responses to modest hypoglycaemia in patients with Type 1 diabetes.
Authors: Kerr, D., Cheyne, E., Thomas, P. and Sherwin, R.
Journal: Diabet Med
Volume: 24
Issue: 3
Pages: 312-316
ISSN: 0742-3071
DOI: 10.1111/j.1464-5491.2006.02054.x
Abstract:AIMS: To determine whether mild alcohol intoxication (45-50 mg/dl) influences counterregulatory hormone responses to moderate hypoglycaemia (2.8 mmol/l)in patients with Type 1 diabetes. METHODS: Seventeen subjects (14 male, age range 21-46 years) with Type 1 diabetes underwent four hyperinsulinaemic glucose clamps: euglycaemia with placebo; euglycaemia with alcohol (0.4 g/kg); hypoglycaemia (2.8 mmol/l for 65 min)with placebo; and hypoglycaemia (2.8 mmol/l for 65 min) with alcohol (0.4 g/kg). Arterialized venous blood samples were taken for measurement of insulin and counterregulatory hormones. RESULTS: During hypoglycaemia, peak growth hormone concentrations were significantly lower after alcohol compared with placebo (14.3 +/- 2.9 vs.25.9 +/- 3.4 microg/l,P< 0.001) associated with reduced insulin sensitivity in both hypoglycaemia and euglycaemia studies. CONCLUSIONS: We found an attenuated growth hormone response to hypoglycaemia associated with mild alcohol intoxication. Although this may potentially contribute to impaired recovery of glucose after hypoglycaemia in patients with Type 1 diabetes, it appears to be offset by a reduction in insulin action.
Source: PubMed
Influence of acute alcohol ingestion on the hormonal responses to modest hypoglycaemia in patients with Type 1 diabetes
Authors: Kerr, D., Cheyne, E., Thomas, P. and Sherwin, R.
Journal: DIABETIC MEDICINE
Volume: 24
Issue: 3
Pages: 312-316
ISSN: 0742-3071
DOI: 10.1111/j.1464-5491.2006.02054.x
Source: Web of Science (Lite)
Influence of acute alcohol ingestion on the hormonal responses to modest hypoglycaemia in patients with Type 1 diabetes
Authors: Kerr, D., Cheyne, E.H., Thomas, P. and Sherwin, R.S.
Journal: Diabetic Medicine
Volume: 24
Pages: 312-316
ISSN: 0742-3071
DOI: 10.1111/j.1464-5491.2006.02054.x
Abstract:Aims To determine whether mild alcohol intoxication (45–50 mg/dl) influences counterregulatory hormone responses to moderate hypoglycaemia (2.8 mmol/l) in patients with Type 1 diabetes.
Methods Seventeen subjects (14 male, age range 21–46 years) with Type 1 diabetes underwent four hyperinsulinaemic glucose clamps: euglycaemia with placebo; euglycaemia with alcohol (0.4 g/kg); hypoglycaemia (2.8 mmol/l for 65 min) with placebo; and hypoglycaemia (2.8 mmol/l for 65 min) with alcohol (0.4 g/kg). Arterialized venous blood samples were taken for measurement of insulin and counterregulatory hormones.
Results During hypoglycaemia, peak growth hormone concentrations were significantly lower after alcohol compared with placebo (14.3 ± 2.9 vs. 25.9 ± 3.4 µg/l, P < 0.001) associated with reduced insulin sensitivity in both hypoglycaemia and euglycaemia studies.
Conclusions We found an attenuated growth hormone response to hypoglycaemia associated with mild alcohol intoxication. Although this may potentially contribute to impaired recovery of glucose after hypoglycaemia in patients with Type 1 diabetes, it appears to be offset by a reduction in insulin action.
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1464-5491.2006.02054.x
Source: Manual
Preferred by: David Kerr
Influence of acute alcohol ingestion on the hormonal responses to modest hypoglycaemia in patients with Type 1 diabetes.
Authors: Kerr, D., Cheyne, E., Thomas, P. and Sherwin, R.
Journal: Diabetic medicine : a journal of the British Diabetic Association
Volume: 24
Issue: 3
Pages: 312-316
eISSN: 1464-5491
ISSN: 0742-3071
DOI: 10.1111/j.1464-5491.2006.02054.x
Abstract:Aims
To determine whether mild alcohol intoxication (45-50 mg/dl) influences counterregulatory hormone responses to moderate hypoglycaemia (2.8 mmol/l)in patients with Type 1 diabetes.Methods
Seventeen subjects (14 male, age range 21-46 years) with Type 1 diabetes underwent four hyperinsulinaemic glucose clamps: euglycaemia with placebo; euglycaemia with alcohol (0.4 g/kg); hypoglycaemia (2.8 mmol/l for 65 min)with placebo; and hypoglycaemia (2.8 mmol/l for 65 min) with alcohol (0.4 g/kg). Arterialized venous blood samples were taken for measurement of insulin and counterregulatory hormones.Results
During hypoglycaemia, peak growth hormone concentrations were significantly lower after alcohol compared with placebo (14.3 +/- 2.9 vs.25.9 +/- 3.4 microg/l,P< 0.001) associated with reduced insulin sensitivity in both hypoglycaemia and euglycaemia studies.Conclusions
We found an attenuated growth hormone response to hypoglycaemia associated with mild alcohol intoxication. Although this may potentially contribute to impaired recovery of glucose after hypoglycaemia in patients with Type 1 diabetes, it appears to be offset by a reduction in insulin action.Source: Europe PubMed Central