Quality of case reports of adverse drug reactions with psychotropic drugs: A 25-year review
Authors: Talat, B., Baldwin, D.S. and Mayers, A.
Journal: Human Psychopharmacology
eISSN: 1099-1077
ISSN: 0885-6222
DOI: 10.1002/hup.2329
Abstract:Case reports of adverse reactions with psychotropic drugs can be useful in raising hypotheses, to be tested with more rigorous study designs. However such reports have significant methodological drawbacks, making it hard to determine causality. We undertook a systematic assessment of the quality of case reports and small case series published within Human Psychopharmacology over 25years. For reports of adverse drug reactions, modified Bradford Hill criteria for causality (for consistency, strength, specificity, temporal relationship and plausibility) were used to ascertain the quality of the account. Reports which had been cited at least 10 times by December 2010 were examined in detail, to assess their overall contribution in extending understanding and influencing clinical practice. Of 40 reports of adverse drug reactions, only seven were sufficiently robust for confidence in probable or possible causality. Nine reports had been cited more than 10 times: the five most frequently cited reports of adverse drug reactions described movement disorders, suicidal thoughts and discontinuation symptoms with SSRIs: clinical relevance was high, but their quality was not markedly greater than less frequently cited reports. Nearly all reports of adverse drug reactions, published in a single journal over 25years, were insufficiently robust to demonstrate probable causality. Reports that are cited frequently become influential because of their potential clinical relevance, rather than due to their methodological quality. © 2013 John Wiley & Sons, Ltd.
Source: Scopus
Quality of case reports of adverse drug reactions with psychotropic drugs: a 25-year review.
Authors: Talat, B., Mayers, A. and Baldwin, D.S.
Journal: Hum Psychopharmacol
Volume: 28
Issue: 5
Pages: 413-420
eISSN: 1099-1077
DOI: 10.1002/hup.2329
Abstract:Case reports of adverse reactions with psychotropic drugs can be useful in raising hypotheses, to be tested with more rigorous study designs. However such reports have significant methodological drawbacks, making it hard to determine causality. We undertook a systematic assessment of the quality of case reports and small case series published within Human Psychopharmacology over 25 years. For reports of adverse drug reactions, modified Bradford Hill criteria for causality (for consistency, strength, specificity, temporal relationship and plausibility) were used to ascertain the quality of the account. Reports which had been cited at least 10 times by December 2010 were examined in detail, to assess their overall contribution in extending understanding and influencing clinical practice. Of 40 reports of adverse drug reactions, only seven were sufficiently robust for confidence in probable or possible causality. Nine reports had been cited more than 10 times: the five most frequently cited reports of adverse drug reactions described movement disorders, suicidal thoughts and discontinuation symptoms with SSRIs: clinical relevance was high, but their quality was not markedly greater than less frequently cited reports. Nearly all reports of adverse drug reactions, published in a single journal over 25 years, were insufficiently robust to demonstrate probable causality. Reports that are cited frequently become influential because of their potential clinical relevance, rather than due to their methodological quality.
Source: PubMed
Quality of case reports of adverse drug reactions with psychotropic drugs: a 25-year review
Authors: Talat, B., Mayers, A. and Baldwin, D.S.
Journal: HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
Volume: 28
Issue: 5
Pages: 413-420
ISSN: 0885-6222
DOI: 10.1002/hup.2329
Source: Web of Science (Lite)
Quality of case reports of adverse drug reactions with psychotropic drugs
Authors: Mayers, A., Talat, B. and Baldwin, D.
Journal: Human Psychopharmacology
Source: Manual
Preferred by: Andrew Mayers
Quality of case reports of adverse drug reactions with psychotropic drugs: a 25-year review.
Authors: Talat, B., Mayers, A. and Baldwin, D.S.
Journal: Human psychopharmacology
Volume: 28
Issue: 5
Pages: 413-420
eISSN: 1099-1077
ISSN: 0885-6222
DOI: 10.1002/hup.2329
Abstract:Case reports of adverse reactions with psychotropic drugs can be useful in raising hypotheses, to be tested with more rigorous study designs. However such reports have significant methodological drawbacks, making it hard to determine causality. We undertook a systematic assessment of the quality of case reports and small case series published within Human Psychopharmacology over 25 years. For reports of adverse drug reactions, modified Bradford Hill criteria for causality (for consistency, strength, specificity, temporal relationship and plausibility) were used to ascertain the quality of the account. Reports which had been cited at least 10 times by December 2010 were examined in detail, to assess their overall contribution in extending understanding and influencing clinical practice. Of 40 reports of adverse drug reactions, only seven were sufficiently robust for confidence in probable or possible causality. Nine reports had been cited more than 10 times: the five most frequently cited reports of adverse drug reactions described movement disorders, suicidal thoughts and discontinuation symptoms with SSRIs: clinical relevance was high, but their quality was not markedly greater than less frequently cited reports. Nearly all reports of adverse drug reactions, published in a single journal over 25 years, were insufficiently robust to demonstrate probable causality. Reports that are cited frequently become influential because of their potential clinical relevance, rather than due to their methodological quality.
Source: Europe PubMed Central